A companion Website includes fully searchable text, interactive review questions and problems, updated Simbryo animations of embryologic system development, and PowerPoint slides for instructors.
Contents Part 1 General Embryology
Chapter 1 Embryology: Old and New Frontiers and an Introduction to Molecular Regulation and Signaling 3
Clinical Relevance 3
A Brief History of Embryology 4
Introduction to Molecular Regulation and Signaling 5
Chapter 2 Gametogenesis: Conversion of Germ Cells Into Male and Female Gametes 13
Primordial Germ Cells 13
Clinical Correlates 13
The Chromosome Theory of Inheritance 14
Clinical Correlates 16
Morphological Changes During Maturation of the Gametes 24
Clinical Correlates 30
Chapter 3 First Week of Development: Ovulation to Implantation 33
Ovarian Cycle 33
Clinical Correlates 33
Fertilization 36
Clinical Correlates 40
Cleavage 41
Blastocyst Formation 41
Uterus at Time of Implantation 43
Clinical Correlates 43
Chapter 4 Second Week of Development: Bilaminar Germ Disc 47
Day 8 47
Day 9 47
Days 11 and 12 48
Day 13 50
Clinical Correlates 51
Chapter 5 Third Week of Development: Trilaminar Germ Disc 55
Gastrulation: Formation of Embryonic Mesoderm and Endoderm 55
Formation of the Notochord 55
Establishment of the Body Axes 56
Fate Map Established During Gastrulation 61
Growth of the Embryonic Disc 61
Clinical Correlates 61
Further Development of the Trophoblast 63
Chapter 6 Third to Eighth Weeks: The Embryonic Period 67
Derivatives of the Ectodermal Germ Layer 67
Clinical Correlates 73
Derivatives of the Mesodermal Germ Layer 74
Clinical Correlates 81
Derivatives of the Endodermal Germ Layer 82
Patterning of the Anteroposterior Axis: Regulation by Homeobox Genes 84
External Appearance During the Second Month 85
Clinical Correlates 87
Chapter 7Third Month to Birth: The Fetus and Placenta 91
Development of the Fetus 91
Fetal Membranes and Placenta 95
Clinical Correlates 95
Clinical Correlates 97
Structure of the Placenta 100
Clinical Correlates 102
Clinical Correlates 103
Amnion and Umbilical Cord 104
Clinical Correlates 105
Placental Changes at the End of Pregnancy 105
Clinical Correlates 106
Amniotic Fluid 106
Fetal Membranes in Twins 106
Clinical Correlates 109
Parturition (Birth) 111
Clinical Correlates 111
Chapter 8 Birth Defects and Prenatal Diagnosis 113
Birth Defects 113
Clinical Correlates 120
Prenatal Diagnosis 121
Fetal Therapy 123
Part 2 Systems-Based Embryology
Chapter 9 Skeletal System 127
Skull 127
Clinical Correlates 131
Limbs 134
Clinical Correlates 140
Vertebrae and the Vertebral Column 142
Ribs and Sternum 144
Clinical Correlates 144
Clinical Correlates 145
Chapter 10 Muscular System 147
Striated Skeletal Musculature 147
Innervation of Axial Skeletal Muscle 147
Molecular Regulation of Muscle Development 149
Patterning of Muscles 150
Head Musculature 150
Limb Musculature 150
Cardiac Muscle 151
Smooth Muscle 151
Clinical Correlates 152
Chapter 11 Body Cavities 155
Formation of the Intraembryonic Cavity 155
Serous Membranes 155
Clinical Correlates 156
Diaphragm and Thoracic Cavity 159
Formation of the Diaphragm 159
Clinical Correlates 162
Chapter 12 Cardiovascular System 165
Establishment of the Cardiogenic Field 165
Formation and Position of the Heart Tube 165
Formation of the Cardiac Loop 168
Clinical Correlates 170
Molecular Regulation of Cardiac Development 170
Development of the Sinus Venosus 171
Formation of the Cardiac Septa 173
Clinical Correlates 173
Clinical Correlates 177
Clinical Correlates 183
Formation of the Conducting System of the Heart 185
Vascular Development 185
Clinical Correlates 190
Clinical Correlates 195
Circulation Before and After Birth 196
Chapter 13 Respiratory System 201
Formation of the Lung Buds 201
Clinical Correlates 202
Larynx 203
Trachea, Bronchi, and Lungs 203
Maturation of the Lungs 205
Clinical Correlates 206
Chapter 14 Digestive System 209
Divisions of the Gut Tube 209
Molecular Regulation of Gut Tube Development 210
Mesenteries 211
Foregut 212
Clinical Correlates 213
Clinical Correlates 218
Molecular Regulation of Liver Induction 221
Clinical Correlates 221
Pancreas 222
Clinical Correlates 223
Midgut 223
Clinical Correlates 227
Hindgut 230
Clinical Correlates 231
Chapter 15 Urogenital System 235
Urinary System 235
Clinical Correlates 240
Clinical Correlates 242
Clinical Correlates 245
Genital System 246
Clinical Correlates 254
Clinical Correlates 257
Clinical Correlates 258
Clinical Correlates 262
Chapter 16 Head and Neck 265
Pharyngeal Arches 267
Pharyngeal Pouches 271
Pharyngeal Clefts 273
Molecular Regulation of Facial Development 273
Clinical Correlates 275
Tongue 277
Clinical Correlates 278
Thyroid Gland 278
Clinical Correlates 279
Face 280
Intermaxillary Segment 282
Secondary Palate 283
Clinical Correlates 284
Nasal Cavities 287
Teeth 287
Molecular Regulation of Tooth Development 290
Clinical Correlates 290
Chapter 17 Central Nervous System 293
Spinal Cord 294
Clinical Correlates 302
Brain 303
Clinical Correlates 310
Molecular Regulation of Brain Development 313
Clinical Correlates 315
Cranial Nerves 319
Autonomic Nervous System 319
Clinical Correlates 323
Chapter 18 Ear 327
Internal Ear 327
Middle Ear 330
External Ear 332
Clinical Correlates 333
Chapter 19 Eye 335
Optic Cup and Lens Vesicle 335
Retina, Iris, and Ciliary Body 337
Lens 339
Choroid, Sclera, and Cornea 339
Vitreous Body 339
Optic Nerve 340
Molecular Regulation of Eye Development 340
Clinical Correlates 342
Chapter 20 Integumentary System 345
Skin 345
Clinical Correlates 346
Clinical Correlates 346
Hair 347
Clinical Correlates 348
Sweat Glands 348
Mammary Glands 348
Clinical Correlates 349
Part 3 Appendix
Answers to Problems 353
Glossary of Key Terms 362
Figure Credits 369
Index 373
Product Details
- Paperback: 385 pages
- Publisher: Lippincott Williams & Wilkins; Eleventh, North American Edition edition (January 30, 2009)
- Language: English
- ISBN-10: 0781790697
- ISBN-13: 978-0781790697
- Product Dimensions: 9.9 x 6.9 x 0.6 inches
- List Price: $63.95