The study of stem cells is beginning to define a newera inmedicine and biomedical research. The investigation of these remarkable cells promises potential therapies for numerous diseases and injuries. Stem cells are loosely defined as cells that are able to replicate into many different cell types, while retaining the ability to replenish their own numbers. More precisely, the essential characteristics of a stem cell include the ability to:
(1) retain the potential for self-renewal and
(2) sustain the population of at least one functional, differentiated cell type. Numerous sources of stem cells exist.
We know, for instance, that stem cells from umbilical cord blood are medicinally valuable as a treatment of hematological disorders, and we suspect that stem cells from the Wharton’s jelly may prove to be the source used for co-transplantation with hematopoetic stem cells to improve engraftment and aid the treatment of hypoxic ischemic encephalopathy or even cancer.
With this book, the public, both scientists and lay people alike, will be educated about the incredible potential of perinatal stem cells, the stem cells generated as a result of pregnancy that fall on the continuum between embryonic stem cells and adult stem cells.
Contents
1 CORD BLOOD TRANSPLANTS: PERINATAL STEM CELLS IN CLINICAL PRACTICE
13 FETAL CELL MICROCHIMERISM, A LOW-GRADE NATURALLY OCCURRING CELLTHERAPY
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(1) retain the potential for self-renewal and
(2) sustain the population of at least one functional, differentiated cell type. Numerous sources of stem cells exist.
We know, for instance, that stem cells from umbilical cord blood are medicinally valuable as a treatment of hematological disorders, and we suspect that stem cells from the Wharton’s jelly may prove to be the source used for co-transplantation with hematopoetic stem cells to improve engraftment and aid the treatment of hypoxic ischemic encephalopathy or even cancer.
With this book, the public, both scientists and lay people alike, will be educated about the incredible potential of perinatal stem cells, the stem cells generated as a result of pregnancy that fall on the continuum between embryonic stem cells and adult stem cells.
Contents
1 CORD BLOOD TRANSPLANTS: PERINATAL STEM CELLS IN CLINICAL PRACTICE
- Introduction
- Hematopoietic Stem Cell Transplants: Adult Donor Collection
- Hematopoietic Stem Cell Transplants: Adult Donor Testing
- Hematopoietic Stem Cell Transplants: Recipient Issues
- Collection and Processing of Cord Blood Units
- Bone Marrow versus Single Cord Blood: Pediatric
- Bone Marrow versus Cord Blood: Adults
- Cord Blood Transplant: Advantages and Disadvantages
- Double Cord Blood Transplants: Ablative Regimens
- Double Cord Blood Transplant: Non-Myeloablative Regimens
- Chimerism
- Predicting the Winner
- Are Two Cords Better Than One?
- Other Experimental Strategies
- Summary
- Introduction: Hematopoietic Stem Cells, the Therapeutic Distributed Stem Cells in Umbilical Cord Blood
- Biological Barriers to Hematopoietic Stem Cell Therapy
- Umbilical Cord Blood: An Ideal Source of Therapeutic Hematopoietic Stem Cells
- Shortcomings of Ex Vivo HSC Expansion Strategies
- A Novel Strategy With Potential to Enable Ex Vivo Expansion of Umbilical Cord Blood Hematopoietic Stem Cells
- Acknowledgments
- Introduction
- Principles of Tissue Engineering
- Cell Sources for Tissue Engineering
- Examples of Possible Use and Implications of Perinatal Stem Cells
- Placental Derived Stem Cells (Chorionic, Amniotic Membranes)
- Amniotic Derived Stem Cells (hAMSC/Placental!)
- Amniotic Fluid-Derived Stem Cells (Nonplacental!)
- Conclusion
- The Fetus as Recipient for Pre- and Perinatal Stem Cell Transplantation
- Prenatal Cell Transplantation: Current Experience
- How Do We Improve the Success of Prenatal Stem Cell Transplantation?
- Mesenchymal Stem Cells for Prenatal Transplantation
- Fetal Gene Therapy as a New Strategy
- Current Issues of Postnatal Gene Therapy
- Prenatal Gene Therapy
- Animal Models of Prenatal Gene Therapy
- Fetal Gene Therapy Targeting Hematopoietic Stem Cells
- Safety Aspects of Prenatal Gene Therapy
- Ethical Considerations
- Preparation and Culture of UC–MSC
- Characteristics–Properties and Bone Marrow Comparison
- UC–MSC as Feeder Layer for Expansion of Human Cells
- Clinical Indications for UC–MSC
- Mesenchymal Stromal Cells
- Immunophenotype of Mesenchymal Stromal Cells
- MSCs are Multipotent Cells
- MSC and Stromal Support of the Stem Cell Niche
- Defining Primitive Stromal Cells: Differences between Fetal and Adult MSCs
- Umbilical Cord MSCs
- Characterization of Wharton’s Jelly Derived Cells
- Other MSC-Like Cells from Umbilical Cord
- Comparison of WJCs to Adult Derived MSCs
- In Vitro Differentiation of WJCs
- Comparison of WJCs to Fetal MSCs
- Transplantation of WJCs
- WJCs as Primitive Stromal Cells
- Summary
- Acknowledgments
- The Role of Vascular Stem Cells in Postnatal Blood Vessel Formation: Endothelial Progenitor Cells and Postnatal Vasculogenesis
- Sources of Endothelial Progenitor Cells
- EPCs, Vasculogenesis and Angiogenesis
- EPCs and Tissue Engineering
- EPCs and Cardiovascular Tissue Engineering
- The Future: Vascularized Engineered Tissue
- Introduction
- Mast Cell Triggers
- Mast Cell Mediators
- Selective Release of Mast Cell Mediators
- Natural Mast Cell Secretion Inhibitors
- Mast–T Cell Interaction
- Inflammatory Skin Diseases
- Fibromyalgia Syndrome
- Asthma
- Inflammatory Arthritis
- Coronary Inflammation
- Ocular Hypersensitivity Reactions
- Conclusion
- Introduction
- Amniotic Fluid Cells
- The Discovery of Stem Cells in Amniotic Fluid
- Cultivation of Amniotic Fluid Derived Stem Cells
- Characteristics of Amniotic Fluid Derived Stem Cells
- Differentiation Potential of Amniotic Fluid Stem Cells
- Amniotic Fluid as a Promising Alternative Source for Neural Stem Cells
- Current Applications of Amniotic Fluid Stem Cells in Therapy
- Amniotic Fluid Stem Cells Banking
- Introduction
- Amnion and Its Properties
- Isolation and Culture of hAE Cells
- Stem Cell Characteristics of Amniotic Epithelium-Derived Cells
- Differentiation of hAE Cells
- Future Directions
- Conclusions
- Acknowledgment
- Human Umbilical Vein Endothelial Cells
- Role of Angiogenesis in the Pathophysiology of Disease
- HMG–CoA Reductase Inhibitors have Therapeutic Effects that are Both Dependent and Independent of Cholesterol Lowering
- Studies of the Effects of Statins on Angiogenesis Using Both In Vivo Models and In Vitro HUVEC and HDMEC Models for Angiogenesis
- Introduction
- The Hematopoietic System
- Historical Perspective on Placental Hematopoiesis
- Development and Structure of the Mouse Placenta
- Hematopoietic Activity in the Mouse Placenta
- Phenotype of Placental HSCs
- Origin and Localization of Placental HSCs
- Summary and Future Directions
13 FETAL CELL MICROCHIMERISM, A LOW-GRADE NATURALLY OCCURRING CELLTHERAPY
- Introduction
- The Placenta is a Source of Stem Cells
- Transfer of Fetal Progenitor Cells During Gestation
- Fetal Progenitor Cells in Maternal Tissues
- Future Therapies
Book Details
- Hardcover: 222 pages
- Publisher: Wiley-Blackwell; 1 edition (August 3, 2009)
- Language: English
- ISBN-10: 0470420847
- ISBN-13: 978-0470420843
- Product Dimensions: 10 x 6.9 x 0.8 inches
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