The elucidation of the coagulation cascade has been one of the major accomplishments of biomedical sciences in recent years. The central role of thrombin, the plethora of factors and the multiple control mechanisms involved in haemostasis have been well characterized. However, new insights in the structure, functions and regulatory roles of thrombin in vascular physiology and development, in neuronal system, in tumor biology, tissue repair and angiogenesis have been gained by new powerful techniques and pioneering work of leading scientists.
In the chapters of this book it was attempted to provide a comprehensive present day view of thrombin, as an enzyme in relation to blood coagulation and in relation to its receptors. The effects of thrombin on various cell types and in patho-physiological conditions are discussed. This book is written to integrate the current understanding of thrombin basic mechanisms in vascular, inflammatory, neuronal and tumor cells and molecular biology with the experimental and clinical implications of these advances. Our goal was not to provide an exhaustively referenced compendium of the many topics that touch upon thrombin functions. Instead, we sought to create a practical and concise summary that would be equally useful for those first entering the field and for those with expertise in one facet of thrombin function wishing to learn more about others. Special emphasis was given to the new roles of thrombin and its receptors in vascular and tumor biology as well as angiogenesis, which present a challenge to translate this knowledge to therapeutic targets.
This book will solidify the concept that thrombin and its receptors are a dynamic, vibrant field with clear implications for understanding the pathogenesis of several diseases (cardiovascular, neuronal, cancer) and for the treatment of patients. We hope that it will serve as a useful resource, not only for those involved in education and in the pursuit of new research programs, but also for those caring for patients with above diseases.
Contents
1 Thrombin: Structure, Functions, and Regulation
2 Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation
3 Regulation of Thrombin Receptor Signaling
4 Thrombin and Activated Protein C: Integrated to Regulate Vascular Physiology
5 The Role of Thrombin in Vascular Development
6 The Role of Thrombin in Angiogenesis
7 Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair
8 The Role of Thrombin and Thrombin Receptors in the Brain
9 The Role of Thrombin in Tumor Biology
10 The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation
11 Anti-thrombotic Therapy in Cancer Patients
12 Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application
13 Novel Anticoagulant Therapy: Principle and Practice
Index
In the chapters of this book it was attempted to provide a comprehensive present day view of thrombin, as an enzyme in relation to blood coagulation and in relation to its receptors. The effects of thrombin on various cell types and in patho-physiological conditions are discussed. This book is written to integrate the current understanding of thrombin basic mechanisms in vascular, inflammatory, neuronal and tumor cells and molecular biology with the experimental and clinical implications of these advances. Our goal was not to provide an exhaustively referenced compendium of the many topics that touch upon thrombin functions. Instead, we sought to create a practical and concise summary that would be equally useful for those first entering the field and for those with expertise in one facet of thrombin function wishing to learn more about others. Special emphasis was given to the new roles of thrombin and its receptors in vascular and tumor biology as well as angiogenesis, which present a challenge to translate this knowledge to therapeutic targets.
This book will solidify the concept that thrombin and its receptors are a dynamic, vibrant field with clear implications for understanding the pathogenesis of several diseases (cardiovascular, neuronal, cancer) and for the treatment of patients. We hope that it will serve as a useful resource, not only for those involved in education and in the pursuit of new research programs, but also for those caring for patients with above diseases.
Contents
1 Thrombin: Structure, Functions, and Regulation
2 Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation
3 Regulation of Thrombin Receptor Signaling
4 Thrombin and Activated Protein C: Integrated to Regulate Vascular Physiology
5 The Role of Thrombin in Vascular Development
6 The Role of Thrombin in Angiogenesis
7 Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair
8 The Role of Thrombin and Thrombin Receptors in the Brain
9 The Role of Thrombin in Tumor Biology
10 The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation
11 Anti-thrombotic Therapy in Cancer Patients
12 Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application
13 Novel Anticoagulant Therapy: Principle and Practice
Index
Book Details
- Hardcover: 248 pages
- Publisher: Springer; 2nd Printing. edition (December 2, 2008)
- Language: English
- ISBN-10: 0387096361
- ISBN-13: 978-0387096360
- Product Dimensions: 9.4 x 6.7 x 0.6 inches