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Braunwald: Atlas of Internal Medicine 2nd Edition

2011-10-17T06:22:00.000-07:00

There are three principal approaches to learning medicine and keeping abreast of new developments: the printed word, in the form of textbooks and journals; the spoken word, in the form of lectures and audiotapes; and the picture, in the form of atlases, slides, and video and computer images. Each approach has its place in the educational armamentarium, and each lends itself to imparting certain facts, ideas, and concepts best. Many aspects of internal medicine require the visual approach. How better to describe a rash, a management algorithm, an echocardiogram, or the appearance of a duodenal ulcer?

In the present healthcare milieu, a solid foundation in internal medicine has assumed greater significance as the role of the primary care physician has expanded. This second edition of the Atlas of Internal Medicine is well-suited as a resource in this expanded role of health maintenance advisor and provider of many services that in the past were often carried out in hospital or in the care of a specialist.

This volume encompasses all the major fields of internal medicine, including cardiology, pulmonary and critical care medicine, gastroenterology, hematology, oncology, dermatology, hepatology, rheumatology, nephrology, neurology, allergy and immunology, endocrinology, and infectious diseases. It is a unique compilation of over 1500 images, selected as the "best of the best" from the work of the highly respected colleagues who have joined me in the preparation of this volume.

The content of each chapter has been carefully selected to be useful to the primary care physician in identifying both common and more rare disease entities. The color photographs provide visual confirmation of disease, while the algorithms, charts, schematics, and tables guide the physician in the decision-making process concerning diagnostic tests, treatment, and follow-up.

I trust that this second edition of the Atlas of Internal Medicine will be useful to the broad array of physicians who wish to remain current in internal medicine and have at their fingertips the most up-to-date reference available.

- Eugene Braunwald MD -

Contents

1. Cardiology
2. Pulmonary and Critical Care Medicine
3. Endocriniology
4. Dermatology
5. Rheumatology
6. Allergy and Immunology
7. Infectious Diseases
8. Neurology
9. Oncology
10. Hematology
11. Gastroenterology
12. Hepatology
13. Nephrology

About the Editor

Eugene Braunwald MD, MD (Hon), ScD (Hon), Distinguished Hersey Professor of Medicine, Harvard Medical School; Faculty Dean for Academics, Brigham and Women's Hospital, Massachusetts General Hospital; Vice President for Academic Programs, Partners Healthcare System, Boston, Massachusetts.

Product Details

Hardcover: 600 pages
Publisher: McGraw-Hill Professional; 2 edition (April 4, 2002)
Language: English
ISBN-10: 0071402403
ISBN-13: 978-0071402408
Product Dimensions: 12.2 x 9.6 x 1.1 inches

List Price: $198.00

Little: Drugs & Pregnancy: A Handbook

2011-10-16T06:26:00.000-07:00

The purpose of this volume was originally to condense and update Drugs and Pregnancy second edition. However, the book has evolved into a larger project since its inception in 2000. The total length of the original typescript was approximately three times the number of pages for which the publisher contracted. First strategy suggested was to eliminate the large number of references, but this was not acceptable. The final compromise developed was to post the full bibliography and supporting materials on a website for the book – http://www.drugsandpregnancy.com.

It is intended for the content of this book to be updated and corrected – as necessary – approximately four times per year. These additions to the book will be posted to the website above, which will be maintained by the publisher. In addition, a searchable index of proprietary and generic names is provided on the website.

In addition, a link to TERIS is provided on the website, and the reader is strongly encouraged to use TERIS in counseling patients who have been exposed to a medication during pregnancy. The information in TERIS has been vetted by leading authorities in the field, and is tantamount to high quality peer reviewed literature. It was through working on the development of TERIS (writing agent summaries, knowledgebase design) from 1985 to 1989 that I became deeply interested in human teratology.

Links to other sites that may be of use to readers of this book will also be included on the website. A feature under development for http://www.drugsandpregnancy.com is a current literature alert window. We have developed an automated search agent that will identify new publications (journal articles, books, etc.) relevant to human teratology, and will post those to the website under CURRENT LITERATURE ALERTS. This will assist the reader in maintaining access to up-to-date information. The main advantage of having a website accompany the published book is currency of information. Books usually take a year or longer to reach the reader after the author has completed the typescript, and may already be out-of-date by the time of release.

I thank the publisher for providing this option to:

(1) maintain scholarly references for the book’s content,

(2) provide readers the most recent information available, and

(3) refer readers to other authoritative sources such as TERIS.

- The Author -

Product Details

Paperback: 368 pages
Publisher: A Hodder Arnold Publication; 1 edition (November 1, 2006)
Language: English
ISBN-10: 0340809175
ISBN-13: 978-0340809174
Product Dimensions: 9.1 x 6.1 x 0.9 inches

List Price: $45.00

Cui: Atlas of Histology with Functional & Clinical Correlations

2011-10-15T09:02:00.000-07:00

The unique Atlas of Histology with Functional and Clinical Correlations covers fundamental histology topics, integrates this essential information with clinical considerations, and provides multiple opportunities for student review. Explanatory text in each chapter combines with expanded figure legends to provide an atlas that can actually be read.

Key Features

Key Concepts sections providing comprehensive introductions to and summaries of the chapter in an easy-to-read format.
Over 100 Clinical Correlations that conclude the examination of most normal tissues and structures with a discussion and visual example of relevant pathology.
Numerous Clinical Content boxes highlighted in blue among the running text, sharpening the clinical focus.
Synopsis boxes of the key structural and functional characteristics of cells, tissues, and organs, offering more than 50 opportunities for efficient review.
Full labels directly on illustrations and micrographs allowing students to quickly identify structures.
Expanded figure legends reviewing key concepts as applied directly to histology images.
More than 25 Chapter Summary tables summarizing each chapter or section in a high-yield format.
An Appendix explaining the general concept of tissue preparation and staining - key knowledge for the histology student.
Effective organization in three units progresses from the cell to basic tissues to complex organ systems, allowing students to build knowledge as they progress through chapters.
Unique histopathological approach integrates histology with pathology, providing pervasive clinical comments and images.
Full-color art program abounds with more than 1,300 illustrations and micrographs.
Innovative one-page layout style shows light and electron micrographic images of a tissue, a diagrammatic representation of the same tissue, and an example of how this tissue may be modified by a pathological process in one easy-to-absorb column.
An Illustrated Glossary of Histological and Pathological Terms introduces the book and the key terms used throughout.
Overview figures start off each chapter with the basics.
Overview figures start off each chapter with the basics.
Orientation maps provide figure numbers of the more detailed images to come on a simple outline of the human body-a feature unique to this atlas!
Integrated presentation of schematic illustrations with photomicrographs and EMs provide viewers with a complete visual impression.
Both low and high magnifications of photomicrographs are included, allowing students to compare tissues or structures in multiple views.
Online access via thePoint provides students the fully searchable text (including images) and an interactive labeling atlas. An image bank with labels on/off is available for faculty.

Contents

Unit 1 BASIC PRINCIPLES OF CELL STRUCTURE AND FUNCTION

Chapter 1 An Illustrated Glossary of Histological and Pathological Terms
Chapter 2 Cell Structure and Function

Unit 2 BASIC TISSUES

Chapter 3 Epithelium and Glands
Chapter 4 Connective Tissue
Chapter 5 Cartilage and Bone
Chapter 6 Muscle
Chapter 7 Nervous Tissue
Chapter 8 Blood and Hemopoiesis

Unit 3 ORGAN SYSTEMS

Chapter 9 Circulatory System
Chapter 10 Lymphoid Organs
Chapter 11 Respiratory System
Chapter 12 Urinary System
Chapter 13 Integumentary System
Chapter 14 Oral Cavity
Chapter 15 Digestive Tract
Chapter 16 Digestive Glands with Associated Organs
Chapter 17 Endocrine System
Chapter 18 Male Reproductive System
Chapter 19 Female Reproductive System
Chapter 20 Eye
Chapter 21 Ear

Appendix- General Concept of Tissue Preparation and Staining

Product Details

Paperback: 496 pages
Publisher: Lippincott Williams & Wilkins; Pap/Psc edition (July 26, 2010)
Language: English
ISBN-10: 0781797594
ISBN-13: 978-0781797597
Product Dimensions: 10.7 x 8.4 x 0.8 inches

List Price: $72.00

Brody's Human Pharmacology 5th Edition: Molecular to Clinical (Student Consult Series)

2011-10-14T09:56:00.000-07:00

Featuring the contributions of leading faculty, this new edition provides a succinct overview of the most important aspects of pharmacology necessary for a basic understanding of the subject. It reviews the concepts, clinical applications and side effects of pharmacology, placing an emphasis on practical applications of the material, whenever possible. More than 480 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade namesas well as USMLE-style self-assessment questions with answers and rationalesreinforce your mastery of the information. A consistent style of writing and more focused, concise contentprovide for better learning of the essentials.

Online access to Student Consultwhere you'll find:

The complete contents of the book, fully searchable.
Integration Links to bonus content in other Student Consult titles.
15 pharmacology animations.
150 USMLE-style questions, and more further enhances your study and prepares you for exams.

Key Features

Includes online access to Student Consult where you'll find USMLE-style questions, animations showing the actions of various important toxins, and much more.
Focuses on the essential aspects of pharmacology for a solid foundation of knowledge in the subject.
Includes more than 480 full-color illustrations that explain key pharmacologic processes.
Provides between 4 and 6 USMLE-style self-assessment questions at the end of each chapterwith answers and full explanations in the appendixthat help you prepare for exams and master the material.
Uses a templated format that promotes more effective and efficient learning.
Presents color-coded boxes in each chapter that emphasize key points.
Features a clinical emphasis throughout on both the basic science of pharmacology and its clinical relevance.
Includes new Gold Standard content on Student Consult with 200 Professional Drug Monographs for additional information on generic and brand names, mechanism of action, pharmacokinetics, indications and dosage, drug interactions, patient education and much more!

New to This Edition

Features a more consistent style of writingas well as focused, concise contentfor enhanced learning of the essentials.
Presents chapters in a re-arranged order for a more logical approach to learning.
Includes additional biochemistry and physiology information in the introduction for each section for greater understanding.

Contents

Part I: General Principles, Lynn Wecker

1 Pharmacodynamics: Receptors and Concentration-Response Relationships
2 Pharmacokinetics: Absorption, Distribution, Metabolism and Elimination
3 Clinical Pharmacokinetics and Issues in Therapeutics
4 Drug Development, Regulation and Prescription Writing
5 Gene Therapy and Emerging Molecular Therapies
6 Antibodies and Biological Products
7 Herbals and Natural Products
8 Principles of Toxicology

Part II: Drugs Affecting the Peripheral Nervous System, Skeletal and Smooth Muscle, Carl Faingold

9 Introduction to the Autonomic Nervous System
10 Drugs Affecting the Parasympathetic Nervous System and Autonomic Ganglia
11 Drugs Affecting the Sympathetic Nervous System
12 Skeletal Muscle Relaxants
13 Local Anesthetics
14 Histamine and Antihistamines
15 Eicosanoids
16 Drugs to Treat Asthma and Chronic Obstructive Pulmonary Disease
17 Drugs Affecting Uterine Motility
18 Drugs Affecting the Gastrointestinal System

Part III: Drugs Affecting the Cardiovascular, Renal and Circulatory Systems, Stephanie Watts

19 Introduction to the Regulation of Cardiovascular Function
20 Antihypertensive Drugs
21 Diuretic Drugs
22 Antiarrhythmic Drugs
23 Drugs to Treat Heart Failure
24 Vasodilators and Nitric Oxide Synthase
25 Lipid-Lowering Drugs and Atherosclerosis
26 Antithrombotic Drugs

Part IV: Drugs Affecting the Central Nervous System, Lynn Wecker

27 Introduction to the Central Nervous System
28 Treatment of Parkinson's and Alzheimer's Diseases
29 Treatment of Psychotic Disorders
30 Treatment of Affective Disorders
31 Treatment of Anxiety and Insomnia
32 Ethanol, Other Alcohols and Drugs for Alcohol Dependence
33 Treatment of Obesity and Eating Disorders
34 Treatment of Seizure Disorders
35 General Anesthetics
36 Drugs to Control Pain
37 Drugs and Substance Abuse, Addiction and Treatment

Part V: Drugs Affecting Endocrine Systems, George Dunaway

38 Introduction to Endocrine Pharmacology and Hormones of the Hypothalamus and Pituitary Gland
39 Adrenocorticosteroids
40 Estrogens and Progestins
41 Androgens and Antiandrogens
42 Thyroid and Antithyroid Drugs
43 Insulin and Drugs Used in the Therapy of Diabetes Mellitus
44 Calcium-Regulating Hormones and Other Agents Affecting Bone

Part VI: Chemotherapy of Invading Organisms, Lynn Crespo

45 Principles of Antimicrobial Use
46 Bacterial Cell Wall Synthesis Inhibitors
47 Inhibitors of Bacterial Ribosomal Actions
48 Bacterial Folate Antagonists, Fluoroquinolones, and Other Antibacterial Agents
49 Antimycobacterial Agents
50 Antifungal Agents
51 Antiviral Agents
52 Drugs to Treat Parasitic Infections

Part VII: Chemotherapy of Neoplastic Diseases, Lynn Crespo

53 Principles of Antineoplastic Drug Use
54 Mechanisms of Action of Antineoplastic Drugs
55 Adjuvant Antineoplastic Drugs

About the Author

Lynn Wecker, PhD, Distinguished University Professor, Departments of Psychiatry and Behavioral Medicine and Molecular Pharmacology and Physiology, Director, Laboratory of Neuropsychopharmacology, USF College of Medicine, Tampa, FL.
Lynn Crespo.
George Dunaway.
Carl Faingold.
Stephanie Watts.

Product Details

Paperback: 719 pages
Publisher: Mosby; 5th edition (March 5, 2010)
Language: English
ISBN-10: 0323053742
ISBN-13: 978-0323053747
Product Dimensions: 10.7 x 8.3 x 1.1 inches

List Price: $79.95

Medical Language Instant Translator 4th Edition

2011-10-13T09:53:00.001-07:00

Communicate more effectively when you use this pocket reference to medical terms and other useful information! Davi-Ellen Chabner's Medical Language Instant Translator, 4th Edition provides the tools you need to understand medical terminology. You can also access key information on common diagnostic tests and procedures, the top 100 prescription drugs, medical abbreviations, symbols, and acronyms - and much more. Based on Chabner's The Language of Medicine, this practical resource is ideal for any health care environment!

Key Features

Get quick, portable access to key medical terms and other need-to-know information.
Decipher complicated medical terms by recognizing and finding the meanings of individual word parts.
Distinguish between commonly misunderstood medical terms (e.g., ureter vs. urethra, or para vs. peri).
Become familiar with common diagnostic tests and procedures and why they are ordered.
Access information on medical abbreviations, symbols, acronyms, and professional designations.
Understand the basics of surgical instruments, terminology, and technology.
Identify the top 100 prescription drugs and their uses.
Quickly access the top 100 diagnoses and associated procedures.
Find the definitions of complementary and alternative medicine terms.
Recognize specialized terms used in medical records.
Review body systems anatomy with full-color illustrations.

New to this edition

Adds a new section on eponyms -words based on or derived from a person's name.
Adds a new section on Major Diagnostic Categories & Diagnosis-Related Groups (DRG).
Includes updates corresponding to those in the Language of Medicine, 9th Edition, by Davi-Ellen Chabner.

Contents

Part I: The Language of Medicine

How to Analyze Medical Terms
Glossary of Word Parts Used in Medical Terminology
Word Parts to English
English to Word Parts
Abbreviations
Symbols
Acronyms
Plurals
Eponyms NEW!
Medical Terms Easily Confused
Specialized Terms Used in Medical Records
Definitions of Diagnostic Tests and Procedures
Radiology, Ultrasound, and Imaging Procedures
Nuclear Medicine Scans
Clinical Procedures
Laboratory Tests

Part II: Useful Information

Abbreviations for Selected Health Care Organizations, Associations, and Agencies
Professional Designations for Health Care Providers
Surgical Terminology and Technology
Surgical Instruments
Complementary and Alternative Medicine Terms
Classes of Drugs and Their Uses
The Top 100 Prescription Drugs (listed alphabetically)
The Top 100 Principal Diagnoses and Associated Principal Procedures
Major Diagnostic Categories & Diagnosis-Related Groups (DRG) NEW!
Normal Hematological Reference Values and Implications of Abnormal Results
Cell Counts
Coagulation Tests
Red Blood Cell Tests
Serum Tests
Internet Resource

Part III: Body Systems Illustrations

Index of Body Systems Illustrations
The Cardiovascular System (Aorta & Major Arteries)
The Cardiovascular System (Heart)
The Digestive System
The Ear
The Endocrine System
The Eye
The Integumentary System
The Lymphatic System
The Anterior Superficial Muscles
The Posterior Superficial Muscles
The Nervous System
The Female Reproductive System
The Male Reproductive System
The Respiratory System
The Skeletal System
The Urinary System

Product Details

Paperback: 328 pages
Publisher: Saunders; 4 edition (2011)
Language: English
ISBN-10: 1437705642
ISBN-13: 978-1437705645
Product Dimensions: 6.9 x 4 x 0.6 inches

List Price: $24.95

Klaus & Fanaroff Care of the High-Risk Neonate 5th Edition

2011-10-12T06:20:00.000-07:00

Remarkably it has been 27 years since the first edition of Care of the High-Risk Neonate was published. Great strides have been taken in the care of high-risk infants, and the outcome for the most complex neonatal disorders is more favorable. Survival rates for even the most immature infants have improved enormously; however, the severe morbidity and long-term neurodevelopmental handicaps among this population remain a major concern. The foundations for the practice of evidence-based neonatology have been laid by a large number of multicenter, randomized trials. Meta-analyses and summation of these trials in the Cochrane Database and other contemporaneous publications assist the practitioners in formulating their care pathways and help ensure the best possible outcomes.

To incorporate the major advances that have occurred since the fourth edition as well as to view the field of neonatal-perinatal medicine in a critical fashion, all the chapters of this fifth edition have un-

dergcne significant reVISIOn. We are pleased to once again welcome several new contributors. One third of the chapters have been rewritten by new contributors who have diligently adhered to the basic format but presented a host of new ideas, fresh approaches, and differing views.

New information is presented in the form of text, critical comments, case problems, or simple questions. Overall, our objective has remained the same: to stimulate the readers and to provide a sound physiologic and experimental basis for perinatal care.

We have been most gratified to learn that this book continues to serve as a guide and companion for neonatal health care providers in many parts of the world.

Our task of completing this fifth edition has been most pleasurable because of the expert editorial assistance provided by Bonnie Siner and Dolores Meloni at W.B. Saunders. We are deeply indebted to them as well as to the many contributors and commenters.

- The Authors -

Table of Contents

1 Antenatal and Intrapartum Care of the High-Risk Infant 1
2 Resuscitation of the Newborn Infant 45
3 Recognition, Stabilization, and Transport of the High-Risk Newborn 65
4 Classification and Physical Examination of the Newborn Infant 100
5 The Physical Environment 130
6 Nutrition and Selected Disorders of the Gastrointestinal Tract 147

Pt. 1 Nutrition for the High-Risk Infant 147
Pt. 2 Selected Disorders of the Gastrointestinal Tract 178
Pt. 3 Necrotizing Enterocolitis 186

7 Care of the Parents 195
8 Nursing Practice in the Neonatal Intensive Care Unit 223
9 Respiratory Problems 243
10 Assisted Ventilation 277
11 Problems in Metabolic Adaptation: Glucose, Calcium, and Magnesium 301
12 Neonatal Hyperbilirubinemia 324
13 Neonatal Infections 363
14 The Heart 393
15 The Kidney 425
16 Hematologic Problems 447
17 Brain Disorders of the Fetus and Neonate 481
18 The Outcome of Neonatal Intensive Care 528
19 Ethical Issues in the Perinatal Period 536
App. A-1 Drugs Used for Emergency and Cardiac Indications in Newborns 548
App. A-2 Drug Dosing Table 550
App. B-1 Drug Compatibility 567
App. C-1 Blood Chemistry Values in Premature Infants During the First 7 Weeks of Life (Birth Weight 1500-1700 g) 570
App. C-2 Other Serum Values 571
App. C-3A Plasma-Serum Amino Acids in Premature and Term Newborns ([mu]mol/L) 572
App. C-3B Reference Serum Amino Acid Concentrations That Have Been Proposed as Standards for Neonates ([mu]mol/L) 573
App. C-4 Normal Hematologic Values 574
App. C-5 Hematologic Values in the First Weeks of Life Related to Gestational Maturity 575
App. C-6 White Cell and Differential Counts in Premature Infants 576
App. C-7 Leukocyte Values and Neutrophil Counts in Term and Premature Infants 577
App. D-1 Urine Amino Acids in Normal Newborns ([mu]mol/d) 578
App. E-1 Siggaard-Anderson Alignment Nomogram 579
App. F-1 Cerebrospinal Fluid Findings in Term and Premature Infants 580
App. F-2 Comparison of WBC Counts in Neonates With and Without Meningitis 582
App. G-1 Fetal Growth Curves for Trimmed and Raw Data 583
App. G-2 Fetal Growth by Selected References 584
App. G-3 Smoothed Percentiles of Birth Weight (g) for Gestational Age US 1991 Single Live Births to Resident Mothers 585
App. G-4 Growth Record for Infants 586
App. G-5 Head Circumference 587
App. G-6 Intrauterine Growth Curves 588
App. G-7 Low-Birth-Weight Infants Daily Growth-Weight 589
App. G-8 Low-Birth-Weight Infants Weekly Growth-Head Circumference 590
App. G-9 Low-Birth-Weight Infants Growth Curves, With and Without Major Morbidities 591
App. G-10 Time of First Void and Stool 592
App. G-11 Mean Arterial Blood Pressure by Birth Weight 593
App. G-12 Blood Pressure by Age and Gestational Age 594
App. G-13 Blood Pressure by Age 595
App. H-1 Percent Mortality and Major Morbidity by Birth Weight 596
App. H-2 Mortality Risk by Birth Weight and Gestational Age 597
App. I-1 Equipment Found on the Umbilical Catheterization Tray, University Hospitals, Cleveland, Ohio 598
App. I-2 Umbilical Vessel Catheterization 599
App. J-1 Conversion of Pounds and Ounces to Grams 603
App. J-2 Conversion Table to Standard International (SI) Units 604
App. J-3 Conversion Tables 606
Index 607

About the Author

Marshall H. Klaus, MD, Adjunct Professor of Pediatrics, University of California at San Francisco, San Francisco, CA.
Avroy A. Fanaroff, MB., (Rand.), FRCPE; Eliza Henry Barnes Chair in Neonatology, Professor of Pediatrics, Case Western Reserve University School of Medicine, Co-Director, Division of Neonatology, Rainbow Babies and Children's Hospital of University Hospitals of Cleveland, Cleveland, OH.

Product Details

Hardcover: 656 pages
Publisher: Saunders; 5 edition (April 27, 2001)
Language: English
ISBN-10: 0721677290
ISBN-13: 978-0721677293
Product Dimensions: 10.4 x 7.3 x 1.2 inches

List Price: $89.95

Reinhart: Basic Flight Physiology 3rd Edition

2011-05-26T19:38:00.000-07:00

Besides complacency, the lack of adequate training and educational resources have been part of the reason all pilots and especially certified flight instructors are not acquainted with, let alone knowledgeable about, flight physiology, hence this textbook. This text is tailored for the beginning pilot, although many civilian pilots are still “beginners” when it comes to flight physiology education. The pilot readers will not only become knowledgeable about the physiology of flight but will also be able to explain why certain things happen to the mind and body in flight, often only in flight.
When learning to fly, simply knowing how to move the stick and rudder does not make a pilot safe or proficient. The more the pilot recognizes why the stick and rudder work, along with airfoils, engines, weather, hydraulics, and the like, the better and safer that pilot will be. The same holds true with understanding how the body and mind can be affected in flight as well as why they are affected in flight.
The chapters are organized to lead the reader from the basics of physiology and physics of flight into the rigors of flight that require a healthy, competent, proficient, and “airworthy” pilot. There is obviously much crossover between the topics. Furthermore, it is common for many physiological situations to be occurring at the same time, which is not a very comforting thought if the pilot isn’t even aware of what’s happening.
The text is not meant to be a comprehensive explanation of all topics. This is not a medical text. After all, medical doctors require many years of education and training just to learn basic medicine. Furthermore, there are many opinions on the same subject. The opinions stated in this text are those shared by many, but there will always be exceptions or disagreement. When there is disagreement or what is stated doesn’t ring true with what you feel is correct, then look for other resources to confirm your interpretation. This is medicine; it’s not an exact science, it’s the “practice of medicine.”
The objective for the reader is to get a clear understanding and overview of the many and varied physiological situations that can interfere with safe flight. Bookshelves are full of supplemental resources to further elaborate on any given topic.
Take hypoxia; the basics of atmospheric physics coupled with the essentials of the body’s circulation system will give the pilot enough information to be respectful and knowledgeable about hypoxia. Further information on the atmosphere to better quantify how hypoxia can severely affect the body is easily found in weather books. The same is true about the circulatory system. This opens the door for expansion on any topic covered in this text; additional references are listed in the recommended reading appendix.
The military has long been the expert in flight physiology and in providing effective training aids. This text is not meant to “reinvent the wheel” and therefore uses some material already presented in military publications. Civilian pilots are constructed the same as military pilots, so the information is somewhat generic. This text presents the material in a logical order for the classroom and concentrates on the situations that arise in civilian operations.
The reader will also find various “reviews” of flight physiology in many books on human factors, basic flying “how-to,” and aviation medicine. Many good articles also appear in trade magazines; however, none seem to take these subjects in depth and relate them to flight for the beginning pilot. Beyond this basic overview of flight physiology, there will be a continuing need to access resources as every pilot matures in flying. This text is also meant to be a resource in a pilot’s personal flying library for future situations dealing with human factors and flight physiology. Time constraints in commercial training do not always adequately reinforce the importance of these essential issues. It’s often up to the pilot to search out the information that will prevent impairment and reduce the risk of a human factors–related incident or accident.
Flight will be more enjoyable and the pilot will be more confident when he or she knows more about how the body and mind function in flight and the many ways that flying skills and safety can be compromised through unintentional, but controllable, abuses of health and fitness to fly.

Contents
1 Human factors defined

Cause and effect
Accident or incident
Definitions of human factors and flight physiology
The “SHEL” model
Incapacitation/impairment
Flight surgeons and aviation medical examiners (AMEs)

2 Basic human anatomy

The nervous system
The musculoskeletal system
The gastrointestinal (GI) system
The metabolic system
The circulatory system
Respiration

3 The atmosphere

Composition of the atmosphere
Physical characteristics of the atmosphere
Gas laws
Divisions of the atmosphere
Physiological divisions of the atmosphere
General effects on the human body

4 Situation awareness

Situation awareness defined
Components of situation awareness
Causes and clues of lost situation awareness
Prevention of lost situation awareness

5 Altitude physiology

The physiology of oxygen in the body
Review of respiration physiology
Carbon monoxide and ozone
Decompression of cabin altitude
Trapped gases
Evolved gas disorders

6 Hearing and vibration

Anatomy and physiology of the ear
Definition of sound
Definition of noise
Perception of sound
Measurement of hearing
Noise and hearing loss
Other types of hearing loss
Hearing conservation
Vibration

7 Vision

The light spectrum
Anatomy of the eye
Optics and physics of light
Correction of acuity
Correction without glasses or contacts
Night vision
Factors affecting visual acuity
Visual scanning
Visual illusions and misperceptions
Black holes and whiteouts
Sunglasses
Ultraviolet radiation

8 Orientation

Disorientation
Definition of disorientation
Types of disorientation
Visual illusions
Tolerance to disorientation and illusions
Flicker vertigo
Motion sickness

9 Self-imposed medical stresses

Self-diagnosis
Over-the-counter medications
Caffeine
Miscellaneous abuses
Physical condition
Alcohol and drugs
It only takes one

10 Environmental stresses

Basic physics of heat
The body’s temperature control system
Coping with heat extremes
Coping with cold extremes
Dehydration
Radiation
Cabin air quality
Toxic chemicals and fumes

11 Sleep, jet lag, and fatigue

Sleep
Circadian rhythms
Fatigue

12 Acceleration

Types of acceleration
Common situations in civilian flying
Symptoms of G forces
Tolerance to G forces
Negative G forces

13 Crew resource management (CRM) and stress management

Definitions in CRM
Resources
Management
Skills learned in CRM
Training in CRM
Deterrents to good CRM
Stress management
Post-traumatic stress disorder (PTSD)

14 Human factors of automation

Cockpit automation defined
Information processing
Physiological impairments
Quantifying impairment

15 Inflight medical emergencies

First aid
On board medical kits
Transporting ill passengers
Basic survival techniques
A reminder

16 Health maintenance program

Nutrition and diet
Hypoglycemia
Exercise
The medical examination
FAA and company flight physicals

17 Medical standards, regulations, and certification

Definitions
Typical certification scenario
Preferred certification scenario
Denial
Re-certification and special issuance

Glossary
Recommended resources for aerospace medicine and flight physiology
Index

Book Details

Hardcover: 311 pages
Publisher: McGraw-Hill Professional; 3 edition
Language: English
ISBN-10: 007149488X
ISBN-13: 978-0071494885
Product Dimensions: 9.3 x 7.4 x 0.9 inches

List Price: $59.95

Cetrulo: Perinatal Stem Cells

2011-05-25T19:44:00.000-07:00

The study of stem cells is beginning to define a newera inmedicine and biomedical research. The investigation of these remarkable cells promises potential therapies for numerous diseases and injuries. Stem cells are loosely defined as cells that are able to replicate into many different cell types, while retaining the ability to replenish their own numbers. More precisely, the essential characteristics of a stem cell include the ability to:
(1) retain the potential for self-renewal and
(2) sustain the population of at least one functional, differentiated cell type. Numerous sources of stem cells exist.
We know, for instance, that stem cells from umbilical cord blood are medicinally valuable as a treatment of hematological disorders, and we suspect that stem cells from the Wharton’s jelly may prove to be the source used for co-transplantation with hematopoetic stem cells to improve engraftment and aid the treatment of hypoxic ischemic encephalopathy or even cancer.
With this book, the public, both scientists and lay people alike, will be educated about the incredible potential of perinatal stem cells, the stem cells generated as a result of pregnancy that fall on the continuum between embryonic stem cells and adult stem cells.

Contents
1 CORD BLOOD TRANSPLANTS: PERINATAL STEM CELLS IN CLINICAL PRACTICE

Introduction
Hematopoietic Stem Cell Transplants: Adult Donor Collection
Hematopoietic Stem Cell Transplants: Adult Donor Testing
Hematopoietic Stem Cell Transplants: Recipient Issues
Collection and Processing of Cord Blood Units
Bone Marrow versus Single Cord Blood: Pediatric
Bone Marrow versus Cord Blood: Adults
Cord Blood Transplant: Advantages and Disadvantages
Double Cord Blood Transplants: Ablative Regimens
Double Cord Blood Transplant: Non-Myeloablative Regimens
Chimerism
Predicting the Winner
Are Two Cords Better Than One?
Other Experimental Strategies
Summary

2 EXPANDING THE THERAPEUTIC POTENTIAL OF UMBILICAL CORD BLOOD HEMATOPOIETIC STEM CELLS

Introduction: Hematopoietic Stem Cells, the Therapeutic Distributed Stem Cells in Umbilical Cord Blood
Biological Barriers to Hematopoietic Stem Cell Therapy
Umbilical Cord Blood: An Ideal Source of Therapeutic Hematopoietic Stem Cells
Shortcomings of Ex Vivo HSC Expansion Strategies
A Novel Strategy With Potential to Enable Ex Vivo Expansion of Umbilical Cord Blood Hematopoietic Stem Cells
Acknowledgments

3 USE OF FETAL CELLS IN REGENERATIVE MEDICINE

Introduction
Principles of Tissue Engineering
Cell Sources for Tissue Engineering
Examples of Possible Use and Implications of Perinatal Stem Cells
Placental Derived Stem Cells (Chorionic, Amniotic Membranes)
Amniotic Derived Stem Cells (hAMSC/Placental!)
Amniotic Fluid-Derived Stem Cells (Nonplacental!)
Conclusion

4 PERINATAL STEM CELL THERAPY

The Fetus as Recipient for Pre- and Perinatal Stem Cell Transplantation
Prenatal Cell Transplantation: Current Experience
How Do We Improve the Success of Prenatal Stem Cell Transplantation?
Mesenchymal Stem Cells for Prenatal Transplantation
Fetal Gene Therapy as a New Strategy
Current Issues of Postnatal Gene Therapy
Prenatal Gene Therapy
Animal Models of Prenatal Gene Therapy
Fetal Gene Therapy Targeting Hematopoietic Stem Cells
Safety Aspects of Prenatal Gene Therapy
Ethical Considerations

5 UMBILICAL CORD MESENCHYMAL STEM CELLS

Preparation and Culture of UC–MSC
Characteristics–Properties and Bone Marrow Comparison
UC–MSC as Feeder Layer for Expansion of Human Cells
Clinical Indications for UC–MSC

6 WHARTON’S JELLY-DERIVED MESENCHYMAL STROMAL CELLS

Mesenchymal Stromal Cells
Immunophenotype of Mesenchymal Stromal Cells
MSCs are Multipotent Cells
MSC and Stromal Support of the Stem Cell Niche
Defining Primitive Stromal Cells: Differences between Fetal and Adult MSCs
Umbilical Cord MSCs
Characterization of Wharton’s Jelly Derived Cells
Other MSC-Like Cells from Umbilical Cord
Comparison of WJCs to Adult Derived MSCs
In Vitro Differentiation of WJCs
Comparison of WJCs to Fetal MSCs
Transplantation of WJCs
WJCs as Primitive Stromal Cells
Summary
Acknowledgments

7 PERINATAL ENDOTHELIAL PROGENITOR CELLS

The Role of Vascular Stem Cells in Postnatal Blood Vessel Formation: Endothelial Progenitor Cells and Postnatal Vasculogenesis
Sources of Endothelial Progenitor Cells
EPCs, Vasculogenesis and Angiogenesis
EPCs and Tissue Engineering
EPCs and Cardiovascular Tissue Engineering
The Future: Vascularized Engineered Tissue

8 UMBILICAL CORD DERIVED MAST CELLS AS MODELS FOR THE STUDY OF INFLAMMATORY DISEASES

Introduction
Mast Cell Triggers
Mast Cell Mediators
Selective Release of Mast Cell Mediators
Natural Mast Cell Secretion Inhibitors
Mast–T Cell Interaction
Inflammatory Skin Diseases
Fibromyalgia Syndrome
Asthma
Inflammatory Arthritis
Coronary Inflammation
Ocular Hypersensitivity Reactions
Conclusion

9 AMNIOTIC FLUID DERIVED STEM CELLS

Introduction
Amniotic Fluid Cells
The Discovery of Stem Cells in Amniotic Fluid
Cultivation of Amniotic Fluid Derived Stem Cells
Characteristics of Amniotic Fluid Derived Stem Cells
Differentiation Potential of Amniotic Fluid Stem Cells
Amniotic Fluid as a Promising Alternative Source for Neural Stem Cells
Current Applications of Amniotic Fluid Stem Cells in Therapy
Amniotic Fluid Stem Cells Banking

10 AMNIOTIC EPITHELIAL STEM CELLS IN REGENERATIVE MEDICINE

Introduction
Amnion and Its Properties
Isolation and Culture of hAE Cells
Stem Cell Characteristics of Amniotic Epithelium-Derived Cells
Differentiation of hAE Cells
Future Directions
Conclusions
Acknowledgment

11 HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS AND HUMAN DERMAL MICROVASCULAR ENDOTHELIAL CELLS OFFER NEW INSIGHTS INTO THE RELATIONSHIP BETWEEN LIPID METABOLISM, ANGIOGENESIS, AND ABDOMINAL AORTIC ANEURYSM

Human Umbilical Vein Endothelial Cells
Role of Angiogenesis in the Pathophysiology of Disease
HMG–CoA Reductase Inhibitors have Therapeutic Effects that are Both Dependent and Independent of Cholesterol Lowering
Studies of the Effects of Statins on Angiogenesis Using Both In Vivo Models and In Vitro HUVEC and HDMEC Models for Angiogenesis

12 HEMATOPOIETIC STEM CELL DEVELOPMENT IN THE PLACENTA

Introduction
The Hematopoietic System
Historical Perspective on Placental Hematopoiesis
Development and Structure of the Mouse Placenta
Hematopoietic Activity in the Mouse Placenta
Phenotype of Placental HSCs
Origin and Localization of Placental HSCs
Summary and Future Directions

13 FETAL CELL MICROCHIMERISM, A LOW-GRADE NATURALLY OCCURRING CELLTHERAPY

Introduction
The Placenta is a Source of Stem Cells
Transfer of Fetal Progenitor Cells During Gestation
Fetal Progenitor Cells in Maternal Tissues
Future Therapies

INDEX

Book Details

Hardcover: 222 pages
Publisher: Wiley-Blackwell; 1 edition (August 3, 2009)
Language: English
ISBN-10: 0470420847
ISBN-13: 978-0470420843
Product Dimensions: 10 x 6.9 x 0.8 inches

List Price: $139.95
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Khurana: Bone Pathology 2nd edition

2011-05-24T19:33:00.000-07:00

This is the second edition of the book A Compendium of Skeletal Pathology published 8 years ago. Similar to the prior edition, the goal of this book is to form a blend between new information and serve as a bench-side companion to the surgical pathologist. In this book, established and tested information is emphasized over the new but untried. In the same spirit, and in order to promote brevity, referencing has been kept to a minimum or eliminated altogether in many chapters. Some chapters however, where there is considerable new information (such as anatomy and molecular biology), are more completely referenced. In this context, I am reminded of Sir Hutchinson’s book of clinical signs and symptoms, which begins “Before handing the cup of knowledge to the youth, wait for the froth to settle.”

There are several changes to this edition. Since there have been several new advances in our understanding of the molecular biology of bone, the first chapter has been extensively rewritten. A new section on the molecular diagnosis of softtissue sarcomas and a new section on biomechanics have been included in this edition. An entirely new chapter on soft-tissue tumors has been added, since there is a close relationship between the soft tissue and bone pathology; and because pathologists, surgeons, and radiologists with an interest in bone often have to deal with soft-tissue tumors as well. The chapter on skeletal dysplasia is updated, but being current on the genetic advances in skeletal dysplasia is almost impossible because of the tremendous speed at which knowledge is accumulating. The interested reader is therefore advised to use the website on Mendelian Inheritance by the National Center for Biotechnology Information. The authors have somewhat reluctantly agreed to concede to the recent trend of doing away with the apostrophe s in eponyms. The reader will therefore, for example, find Paget disease or Ewing sarcoma instead of the more familiar Paget’s disease or Ewing’s sarcoma. We will however continue to miss the apostrophe s for some time to come.Once again, this edition is a combined effort from authors of different specialties including surgeons, pathologists, radiologists, and basic scientists all of whom have in common an interest in bone diseases. Although the book is aimed at the surgical pathology resident, it is hoped that it will be of value to the practicing pathologist, the graduate student, the academic orthopedic surgeon, and the skeletal radiologist.

Contents

1 Bone Structure, Development and Bone Biology
2 Structure and Function of Joints
3 Biomechanics – Part I
4 Biomechanics – Part II
5 The Laboratory in Orthopedic Practice
6 Genetics and Molecular Biology of Bone and Soft Tissue Tumors
7 Grossing of Bone and Soft Tissue (Common Specimens and Procedures)
8 Bone Histomorphometry and Undecalcified Sections
9 Radiology of the Musculoskeletal System
10 Skeletal Trauma and Common Orthopedic Problems
11 The Surgical Pathology of Bone Infections
12 Arthropathies
13 The Surgical Pathology of Prosthetic Materials
14 Osteoporosis and Metabolic Bone Disease
15 Inherited and Dysplastic Conditions of the Skeleton
16 Musculoskeletal Neoplasms: An Introduction
17 The Medical Management of Sarcomas
18 Radiation Therapy for Sarcomas
19 The Surgical Pathology of Bone Tumors and Tumor-Like Lesions
20 Tumors of Soft Tissue
Index

Product Details

Hardcover: 418 pages
Publisher: Humana Press; 2nd edition
Language: English
ISBN-10: 1588297667
ISBN-13: 978-1588297662
Product Dimensions: 11 x 8.4 x 0.9 inches

List Price: $179.00

Mayo Clinic Antimicrobial Therapy: Quick Guide

2011-05-23T19:28:00.000-07:00

The medical management of infectious diseases and antimicrobial therapy can be a daunting task for health care professionals. Although expansive textbooks and online resources are available, we believe that a more simplified, quick reference guide is needed for the day-to-day office and hospital clinical practice. This book is designed to provide information about infectious diseases and antimicrobial therapy in a format that is readily accessible and easily applicable to the clinical environment.

Highlights of this book include simplified and thorough drug dosing recommendations for renal function and renal replacement therapies, drugs of choice for specific organisms (including bacteria, fungi, and viruses), and

simplified antimicrobial and management recommendations for specific infectious syndromes.

This book will assist health care providers in the management of infectious diseases and in the selection of appropriate antimicrobial therapy in a time-efficient manner. This book is not meant to serve as a comprehensive review of all infectious diseases topics. Instead, readers are encouraged to seek supplemental information from additional published resources and from the prescribing information provided by pharmaceutical manufacturers.

Contents

I. Antimicrobial Agent Fundamentals

Spectrum of Activity
Pharmacokinetics of Antimicrobial Agents
Antimicrobial Assays/Drug Levels
Laboratory and Clinical Toxicity Monitoring

II. Antimicrobial Dosing—Adult and Pediatric

Adult Antimicrobial Dosing
Adult Dosing for Continuous Renal Replacement Therapy (CRRT)
Vancomycin Adult Dosing and Monitoring
Aminoglycoside Adult Dosing and Monitoring
Pediatric Antimicrobial Dosing

III. Treatment of Specific Organisms

Bacteria: Preferred and Alternate Treatment Options
Bacterial Drug Resistance Issues
Fungi: Preferred and Alternate Treatment Options
Viruses: Preferred and Alternate Treatment Options

IV. Infectious Syndromes in Adults

Clinical Approach to Patients With Infection
Respiratory Tract Infections
Infective Endocarditis: Diagnosis and Treatment
Infective Endocarditis Prophylaxis
Central Nervous System Infections
Urinary Tract Infections
Soft-Tissue Infections: Nontoxigenic
Soft-Tissue Infections: Necrotizing or Toxigenic
Surgical Prophylaxis
Osteomyelitis
Acute Native Joint Infections
Gastrointestinal Infections
Intra-Abdominal Infections
Neutropenic Fever Empiric Management
Sexually Transmitted Diseases
Tuberculosis
Nontuberculosis Mycobacterial Infections
Zoonotic (Animal-Associated) Infections
Tick-Borne Infections
Fungal Infections
Antiretroviral Therapy for HIV Infection
Select Opportunistic Infections in Adult HIV Patients
Occupational Postexposure Prophylaxis and Management .
Vaccination Schedules
Travel Medicine/Prophylaxis

Product Details

Paperback: 352 pages
Publisher: Informa Healthcare (May 22, 2008)
Language: English
ISBN-10: 1420085182
ISBN-13: 978-1420085181
Product Dimensions: 6.9 x 4.5 x 0.8 inches

List Price: $50.00

LANGE: Review of Medical Microbiology and Immunology 10th Edition

2011-05-22T19:26:00.000-07:00

LANGE: Review of Medical Microbiology and Immunology 10th Edition is a concise review of the medically important aspects of microbiology. It covers both the basic and clinical aspects of bacteriology, virology, mycology, parasitology, and immunology. Its two major aims are (1) to assist those who are preparing for the USMLE (National Boards) and (2) to provide students who are currently taking medical microbiology courses with a brief and up-to-date source of information. My goal is to provide the reader with an accurate source of clinically relevant information at a level appropriate for those beginning their medical education.

This new edition presents current, medically important information in the rapidly changing fields of microbiology and immunology. It contains a new section of color micrographs of stained microorganisms as well as images of important laboratory tests. It also includes a new chapter on ectoparasites, such as the mite that causes scabies, and current information on antimicrobial drugs and vaccines.
These aims are achieved by utilizing several different formats, which should make the book useful to students with varying study objectives and learning styles:

A narrative text for complete information.
A separate section containing summaries of important microorganisms for rapid review of essentials.
Sample questions in the USMLE (National Board) style, with answers provided after each group of questions.
A USMLE (National Board) practice examination consisting of 80 microbiology and immunology questions. The questions are incorporated into a clinical case format and simulate the computer-based examination. Answers are provided at the end of each block of 40 questions.
Clinical case vignettes to provide both clinical information and practice for the USMLE.
A section titled “Pearls for the USMLE” describing important epidemiological information helpful in answering questions on the USMLE.
The following features are included to promote a successful learning experience for students using this book:

The information is presented succinctly, with stress on making it clear, interesting, and up to date.
There is strong emphasis in the text on the clinical application of microbiology and immunology to infectious diseases.
In the clinical bacteriology and virology sections, the organisms are separated into major and minor pathogens. This allows the student to focus on the clinically most important microorganisms.
Key information is summarized in useful review tables. Important concepts are illustrated by figures using color.
Important facts called "Pearls" are listed at the end of each basic science chapter.
The 654 USMLE (National Board) practice questions cover the important aspects of each of the subdisciplines on the USMLE: Bacteriology, Virology, Mycology, Parasitology, and Immunology. A separate section containing extended matching questions is included. In view of the emphasis placed on clinical relevance in the USMLE, another section provides questions set in a clinical case context.
Brief summaries of medically important microorganisms are presented together in a separate section to facilitate rapid access to the information and to encourage comparison of one organism with another.
Fifty clinical cases are presented as unknowns for the reader to analyze in a brief, problem-solving format. These cases illustrate the importance of basic science information in clinical diagnosis.
Seventy color images depicting clinically important findings such as Gram stains of bacteria, electron micrographs of viruses, and microscopic images of fungi, protozoa, and worms.

Book Details

Paperback: 684 pages
Publisher: McGraw-Hill Medical; 10 edition (May 8, 2008)
Language: English
ISBN-10: 0071496203
ISBN-13: 978-0071496209
Product Dimensions: 9.1 x 7.3 x 1.1 inches

List Price: $49.95

Thrombin Physiology and Disease 2nd edition

2011-05-21T09:21:00.000-07:00

The elucidation of the coagulation cascade has been one of the major accomplishments of biomedical sciences in recent years. The central role of thrombin, the plethora of factors and the multiple control mechanisms involved in haemostasis have been well characterized. However, new insights in the structure, functions and regulatory roles of thrombin in vascular physiology and development, in neuronal system, in tumor biology, tissue repair and angiogenesis have been gained by new powerful techniques and pioneering work of leading scientists.
In the chapters of this book it was attempted to provide a comprehensive present day view of thrombin, as an enzyme in relation to blood coagulation and in relation to its receptors. The effects of thrombin on various cell types and in patho-physiological conditions are discussed. This book is written to integrate the current understanding of thrombin basic mechanisms in vascular, inflammatory, neuronal and tumor cells and molecular biology with the experimental and clinical implications of these advances. Our goal was not to provide an exhaustively referenced compendium of the many topics that touch upon thrombin functions. Instead, we sought to create a practical and concise summary that would be equally useful for those first entering the field and for those with expertise in one facet of thrombin function wishing to learn more about others. Special emphasis was given to the new roles of thrombin and its receptors in vascular and tumor biology as well as angiogenesis, which present a challenge to translate this knowledge to therapeutic targets.
This book will solidify the concept that thrombin and its receptors are a dynamic, vibrant field with clear implications for understanding the pathogenesis of several diseases (cardiovascular, neuronal, cancer) and for the treatment of patients. We hope that it will serve as a useful resource, not only for those involved in education and in the pursuit of new research programs, but also for those caring for patients with above diseases.

Contents
1 Thrombin: Structure, Functions, and Regulation
2 Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation
3 Regulation of Thrombin Receptor Signaling
4 Thrombin and Activated Protein C: Integrated to Regulate Vascular Physiology
5 The Role of Thrombin in Vascular Development
6 The Role of Thrombin in Angiogenesis
7 Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair
8 The Role of Thrombin and Thrombin Receptors in the Brain
9 The Role of Thrombin in Tumor Biology
10 The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation
11 Anti-thrombotic Therapy in Cancer Patients
12 Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application
13 Novel Anticoagulant Therapy: Principle and Practice
Index

Book Details

Hardcover: 248 pages
Publisher: Springer; 2nd Printing. edition (December 2, 2008)
Language: English
ISBN-10: 0387096361
ISBN-13: 978-0387096360
Product Dimensions: 9.4 x 6.7 x 0.6 inches

List Price: $139.00

Emery's Elements of Medical Genetics 14th edition: With STUDENT CONSULT Online Access

2011-05-06T09:00:00.000-07:00

Master the genetics you need to know with the updated 14th Edition of Emery's Elements of Medical Genetics by Drs. Peter Turnpenny and Sian Ellard. Review the field's latest and most important topics with user-friendly coverage designed to help you better understand and apply the basic principles of genetics to clinical situations. Learning is easy with the aid of clear, full-color illustrative diagrams, a wealth of clinical photographs of genetic diseases, multiple-choice and case-based review questions, end-of-chapter summaries, and convenient online access at www.studentconsult.com. With this highly visual, award-winning classic in your hands, you have all the genetics knowledge you need for exams or practice.

Features

Get a broad view of medical genetics with a unique three-part structure that looks at the Principles of Human Genetics, Genetics in Medicine, and Clinical Genetics.
Visualize the appearance of genetic disorders with a fantastic art program that presents many clinical photos of genetic diseases, and work through complicated ideas with an array of full-color illustrative diagrams.
Master the material you need to know with a title preferred by faculty and students alike over the last three decades and awarded the British Medical Association Medial Student Textbook of the Year in 2008.

Search the entire contents online at www.studentconsult.com, including 150 USMLE-style multiple choice questions to aid study and self-testing.

New to this edition

Apply the latest research with chapters on developmental genetics, cancer genetics, prenatal testing and reproduction genetics, 'clonal' sequencing, and more.
Understand complex concepts with the help of an increased number of diagrams.
Be fully aware of social, ethical, and counseling issues by reviewing an improved section on these topics.

Book Details

Paperback: 464 pages
Publisher: Churchill Livingstone; 14 edition (March 1, 2011)
Language: English
ISBN-10: 0702040436
ISBN-13: 978-0702040436
Product Dimensions: 10.9 x 8.5 x 0.9 inches

List Price: $62.95

Mahon: Textbook of Diagnostic Microbiology 4th Edition

2011-05-05T08:56:00.000-07:00

Providing a solid introduction to the essentials of diagnostic microbiology, this accessible, full-color text helps you develop the problem-solving skills necessary for success in the clinical setting. A reader-friendly, "building block" approach to microbiology moves progressively from basic concepts to advanced understanding, guiding you through the systematic identification of etiologic agents of infectious diseases.

Key Features

Building block approach encourages recall of previously learned information, enhancing your critical and problem solving skills.
Case in Point feature introduces case studies at the beginning of each chapter.
Issues to Consider encourages you to analyze and comprehend the case in point.
Key Terms provide a list of the most important and relevant terms in each chapter.
Objectives give a measurable outcome to achieve by completing the material.
Points to Remember summarize and help clearly identify key concepts covered in each chapter.
Learning assessment questions evaluate how well you have mastered the material.

New to this edition

New content addresses bone and joint infections, genital tract infections, and nosocomial infections.
Significantly updated chapter includes current information on molecular biology and highlights content on multidrugs resistant bacteria.
Reorganized chapters accent the most relevant information about viruses and parasites that are also transmissible to humans.
Case studies on the Evolve site let you apply the information that you learn to realistic scenarios encountered in the laboratory.

Contents

Part I Introduction to Clinical Microbiology

1. Bacterial Cell Structure, Physiology, Metabolism, and Genetics
2. Host-Parasite Interaction
3. The Laboratory Role in Infection Control
4. Control of Microorganisms
5. Performance Improvement in the Microbiology Laboratory
6. Specimen Collection and Processing
7. Microscopic Examination of Materials from Infected Sites
8. Use of Colonial Morphology for the Presumptive Identification of Microorganisms
9. Biochemical Identification of Gram-Negative Bacteria
10. Immunodiagnosis of Infectious Diseases
11. Applications of Molecular Diagnostics
12. Antibiotic Mechanisms of Action and Resistance
13. Antimicrobial Susceptibility Testing

Part II Laboratory Identification of Significant Isolates

14. Staphylococci
15. Streptococcus, Enterococcus, and Other Catalase-Negative Gram-Positive Cocci
16. Aerobic Gram-Positive Bacilli
17. Neisseria Species and Moraxella catarrhalis
18. Haemophilus and Other Fastidious Gram-Negative Bacilli
19. Enterobacteriaceae
20. Vibrio, Aeromonas, and Campylobacter Species
21. Nonfermenting and Miscellaneous Gram-Negative Bacilli
22. Anaerobes of Clinical Importance
23. Spirochetes
24. Chlamydia and Rickettsia
25. Mycoplasma and Ureaplasma
26. Mycobacterium tuberculosis and Other Nontuberculosis Mycobacteria
27. Medically Significant Fungi
28. Diagnostic Parasitology
29. Clinical Virology
30. Agents of Bioterror
31. Biofilms: Architects of Disease

Part III Laboratory Diagnosis of Infectious Diseases: an Organ System Approach to Diagnostic Microbiology

32. Upper and Lower Respiratory Tract Infections
33. Skin and Soft Tissue Infections
34. Gastrointestinal Infections and Food Poisoning
35. Infections of the Central Nervous System
36. Bacteremia and Sepsis
37. Urinary Tract Infections
38. Genital Infections and Sexually Transmitted Diseases
39. Infections in Special Populations
40. Zoonotic Diseases
41. Ocular Infections

About the Authors

Connie Mahon, MS, MT(ASCP), CLS, Director, Staff College, Center for Veterinary Medicine, Food and Drug Administration, Rockville, MD; Adjunct Faculty, Department of Clinical Laboratory Sciences, School of Medicine and Health Sciences, The George Washington University, Washington DC.
Donald Lehman, EdD, MT(ASCP), SM(NRM), Associate Professor, Department of Medical Technology, University of Delaware, Newark, DE, USA.
George Manuselis, MA, MT(ASCP), Emeritus, Medical Technology Division, The Ohio State University, Columbus, OH; Adjunct Faculty, Department of Natural Sciences and Forensic Science, Central Ohio Technical College, Newark, OH, USA.

Product Details

Hardcover: 1104 pages
Publisher: Saunders; 4 edition (March 9, 2010)
Language: English
ISBN-10: 1416061657
ISBN-13: 978-1416061656
Product Dimensions: 11.1 x 8.8 x 1.7 inches

List Price: $113.00

Turgeon: Immunology and Serology in Laboratory Medicine 4th edition

2011-05-04T08:52:00.000-07:00

Completely updated, the 4th edition of this classic resource offers the current, comprehensive coverage of immunology you need to stay on the cutting-edge of clinical laboratory science. It provides a solid foundation of knowledge and skills to take you from basic immunologic mechanisms and serologic concepts to the theory behind the procedures you'll perform in the lab, including automated techniques. It also explores the medical applications of clinical laboratory science, with information on disorders of infectious and immunologic origin, as well as topics such as transplantation and tumor immunology. Learning objectives, review questions, step-by-step procedures, and case studies help you master key concepts and prepare you to succeed in today's modern laboratory environment.

Features

Author Mary Louise Turgeon, a leader in the field of clinical laboratory science, shares with you her wealth of knowledge and experience in this outstanding textbook.
The book's two-color design provides you with at-a-glance access to special features and vital information.
In-depth chapter outlines prepare you for the material you will be learning in each chapter and help you see how the topics flow and connect to each other.
Learning objectives at the beginning of each chapter allow you to set study goals and assess your progress as you move through the textbook.
Highlights at the end of every chapter summarize the most important points you should take away from the chapter.
Review questions help you assess and reinforce your understanding of chapter content.
Case studies in many of the chapters allow you to see how key concepts apply to real-life scenarios.
Hands-on procedure coverage in many chapters offer detailed descriptions of exactly what happens during every step of laboratory procedures.
A convenient glossary of key terms in the back of the book provides quick access to definitions for new or unfamiliar words.

New to this edition

In addition to completely updated content throughout, four new chapters on quality assurance and quality control, basic serologic laboratory techniques, point-of-care testing, and vaccines bring you the latest advances in the field.
Expanded coverage of automated procedures and molecular techniques keep you up to date on technology and research.
A new full-color insert serves as a vivid visual reference and helps you more easily master complex concepts.
A companion Evolve website offers online access to a wealth of additional review questions, content updates, and web links.

Book Details

Hardcover: 544 pages
Publisher: Mosby; 4 edition (September 11, 2008)
Language: English
ISBN-10: 0323043828
ISBN-13: 978-0323043823
Product Dimensions: 11.1 x 8.6 x 1 inches

List Price: $69.95

Chamberlain: Medical Microbiology: The Big Picture

2011-05-03T08:48:00.000-07:00

Most microbiology professors don’t live in a clinical world. Microbiologists know a lot about the microorganisms that cause human disease, and they go into great detail talking about them. They will then briefly tell you what diseases these pathogens cause. You then learn all these microbial characteristics and organize them by bacterial shape and Gram stain, viral family, fungal classification, or parasitic class, leaving the diseases to hang at the end of each microbial knowledge set.
This approach to teaching medical microbiology creates a dilemma when an attending physician says to his student physicians,“ Dr. Chamberlain’s chest radiograph indicates that he has pneumonia. Tell me the most common cause of typical pneumonia in this middle-aged male?” The way you learned microbiology requires that you recall a catalog of organism by organism to see which ones cause pneumonia. This takes several minutes and before you can answer, your attending says,“Don’t you know that bacteria are the most likely cause of typical pneumonia and that the most common cause of this pneumonia is Streptococcus pneumoniae?” You walk away saying to yourself, “How did my attending get the answer so quick?” What the attending physician did was relearn medical microbiology.
Instead of learning the microorganisms and recalling the diseases they cause, this physician learned how to identify a disease and then created lists of the microorganisms that caused that disease.
In the past, this reorienting of the students’ medical microbiology knowledge was occurring while medical students were completing their clinical rotations. Unfortunately, case-based questions on USMLE and COMLEX, clinically oriented medical school course work, and recently revised medical school curricula require most medical students to reorient or organize their microbiology knowledge in a clinically relevant way even before they begin their clinical years. The Big Picture Medical Microbiology book was written to help you reorient or obtain medical microbiology knowledge in a clinically oriented way and to help you in your clinical rotations.

Organization of the Book
The parade of microorganisms does not exist in this book. This book is organized by organ systems and the infectious diseases caused by microorganisms in that particular system.
The first chapter in each section presents a “Big Picture” overview that explains the organization of the organ system, some immunologic responses that the system uses to ward off infection, and the diseases as well as the common causes of the diseases that are discussed in chapters that follow within each section. Information in each chapter is discussed using similar headings of etiology, manifestations, epidemiology, pathogenesis, diagnosis, and therapy and prevention.
About 280 color images are included to help you visualize many of the diseases; some of the images illustrate the results of laboratory tests that are used to identify certain pathogens.
About 120 tables compare and contrast the various types of a particular disease, summarize the signs and symptoms of a disease, and quickly compare the causes of a disease.
The last section of the book contains 100 case-based examination questions. Over 30 of the questions contain an image that is necessary for you to examine to correctly answer the question. The questions are in random order to better simulate actual board-type examinations.
The Appendix contains 19 summary tables and 2 flow charts, which contain a variety of information about microorganisms that will help refresh your memory.

Contents
SECTION 1: INTEGUMENT AND SOFT TISSUES
CHAPTER 1 The Big Picture: Infections of the Integument and Soft Tissues
CHAPTER 2 Maculopapular Rashes
CHAPTER 3 Papules, Plaques, and Patches
CHAPTER 4 Vesicular, Bullous, and Purulent Lesions
CHAPTER 5 Petechial, Hemorrhagic, Ulcerative, and Necrotic Lesions
SECTION 2: CENTRAL NERVOUS SYSTEM
CHAPTER 6 The Big Picture: Infections of the Central Nervous System
CHAPTER 7 Meningitis and Encephalitis
CHAPTER 8 Poliomyelitis and Tetanus
SECTION 3: EYES AND EARS
CHAPTER 9 The Big Picture: Infections of the Eyes and Ears
CHAPTER 10 Infections of the Eye
CHAPTER 11 Infections of the Ear
SECTION 4: RESPIRATORY TRACT
CHAPTER 12 The Big Picture: Infections of the Respiratory Tract
CHAPTER 13 Infections of the Upper Respiratory Tract
CHAPTER 14 Infections of the Respiratory Airways
CHAPTER 15 Infections of the Lower Respiratory Tract
SECTION 5: GASTROINTESTINAL TRACT AND LIVER
CHAPTER 16 The Big Picture: Infections of the Gastrointestinal Tract and Liver
CHAPTER 17 Infections of the Teeth, Gingivae, and Jaws
CHAPTER 18 Infections of the Mouth, Tongue, and Parotid Glands
CHAPTER 19 Infections of the Esophagus, Stomach, and Upper Duodenum
CHAPTER 20 Liver: Viral Hepatitis
CHAPTER 21 Infections of the Small Intestine 209
CHAPTER 22 Infections of the Large Intestine
SECTION 6: HEMATOPOIETIC AND LYMPHORETICULAR SYSTEMS
CHAPTER 23 The Big Picture: Infections of the Hematopoietic and Lymphoreticular Systems
CHAPTER 24 Lymphocytes
CHAPTER 25 Phagocytic Cells
CHAPTER 26 Erythrocytes
CHAPTER 27 Endothelial Cells
SECTION 7: CIRCULATORY SYSTEM
CHAPTER 28 The Big Picture: Infections of the Circulatory System: Sepsis and Septic Shock
SECTION 8: CARDIOVASCULAR SYSTEM
CHAPTER 29 The Big Picture: Infections of the Cardiovascular System
CHAPTER 30 Pericarditis,Myocarditis, Endocarditis, and Rheumatic Heart Disease
SECTION 9: BONES AND JOINT
CHAPTER 31 The Big Picture: Infections of the Bones and Joints
CHAPTER 32 Osteomyelitis and Septic Arthritis
SECTION 10: GENITOURINARY TRACT
CHAPTER 33 The Big Picture: Infections of the Genitourinary Tract
CHAPTER 34 Infections of the Urethra, Bladder, Kidney, and Prostate
CHAPTER 35 Vaginal Infections
CHAPTER 36 Sexually Transmitted Infections
SECTION 11: QUESTIONS AND DISCUSSIONS
CHAPTER 37 Practice Examination
Answers
APPENDIX Important Medical Microbiology
Laboratory Tests
Index

Book Details

Paperback: 456 pages
Publisher: McGraw-Hill Medical; 1 edition
Language: English
ISBN-10: 007147661X
ISBN-13: 978-0071476614
Product Dimensions: 11.2 x 9 x 0.9 inches

List Price: $51.95

Tietz's Applied Laboratory Medicine 2nd Edition

2011-05-02T08:48:00.000-07:00

It has been said that 80% of all medical decisions encompass clinical laboratory data in the decision process! While we know of no evidence to support this statement it is probably not far off the mark. Laboratory medicine plays an integrated role in the diagnosis, prognosis, treatment, and long-term management of disease. Proper selection and interpretation of laboratory tests is critical for quality patient care. In the last few decades, there has been an information explosion in the field of laboratory medicine, making it difficult for health care professionals to remain fluent in all aspects of laboratory testing. Applied Laboratory Medicine, Second Edition provides a comprehensive overview of modern laboratory medicine in a “real-life” case-based format. Each Case presents a patient with history and accompanying laboratory data. This is followed by discussions of how the laboratory data is used in relation to symptoms and the differential diagnosis. Most discussions also provide a definition of the disease, its pathophysiology, and treatment. We hope this book will be an excellent problem-based learning tool.
The first edition of Applied Laboratory Medicine focused primarily on traditional clinical chemistry tests. In the Second Edition, the case studies have been expanded to include hematology, coagulation, infectious disease, autoimmune disease, and molecular diagnostics. In addition, cases illustrate many new laboratory tests, new treatments, current risk factor guidelines based upon laboratory tests, and new testing algorithms. Furthermore, some examples of common laboratory problems and interferences are presented. Understanding of such interferences is paramount for proper interpretation of laboratory tests that do not fit the clinical presentation. Applied Laboratory Medicine Second Edition will be an excellent resource for medical students during their pathology course, residents, fellows, nurses, physician’s assistants, medical technologists, educators, physicians, laboratorians, and many other allied health workers.

Contents
Part One Cardiac Disease
Case 1. A 45-Year-Old Man with Substantial Chest Pain
Case 2. A 48-Year-Old Cocaine User with Chest Pain
Part Two Pulmonary Diseases
Case 3. Shortness of Breath with Productive Cough
Case 4. Genotype–Phenotype Correlations in Cystic Fibrosis
Part Three Renal Disease
Case 5. Man with Hypertension and Fever
Case 6. Oliguria with Metabolic Acidosis after Renal Transplantation
Case 7. A Woman with Uremia, Pulmonary Infiltration, and Hemoptysis
Case 8. Young Man with Edema and Decreased Urine Output
Case 9. A New Doctor for a Man with Diabetes and Hypertension
Case 10. A Pain in the Back
Case 11. Refractory Hyponatremia with Lung Cancer
Part Four Liver Diseases
Case 12. Adolescent Female with Tremor, Depression, and Hepatitis
Case 13. Adult Male with New-Onset Ascites
Case 14. An Unexpected Finding . . .:
Case 15. I Did It Just Once—A 37-Year-Old Man with Hepatitis C
Case 16. Obese Woman with Persistently Abnormal Liver Enzymes
Part Five Thyroid Diseases
Case 17. The Irritable Wife
Case 18. The Fatigued Attorney
Case 19. The Reluctant Chef
Part Six Adrenocortical Diseases
Case 20. Child with Rapid Growth and Precocious Sexual Maturation
Case 21. Weight Gain, Infertility, and Hypertension
Case 22. The Tired Teenager
Case 23. The Hypertensive Accountant
Richard D. Gordon
Case 24. Don’t “Take Two Aspirin and Call Me in the Morning”
Case 25. Unpleasant Spells
Part Seven Diabetes
Case 26. Recent Weight Loss and Polyuria in a 52-Year-Old Man
Case 27. An Unconscious Diabetic Male
Case 28. A Diabetic Woman’s “Episode”
Part Eight Calcium and Parathyroid Hormone (PTH)
Case 29. Bad to the Bone
Case 30. A Middle-Aged Woman with Colle’s Fracture
Case 31. A 10-Year-Old Boy with Pain-Induced Seizures
Part Nine Miscellaneous Endocrine Diseases
Case 32. Laboratory Tests Ignored
Case 33. Hot Flashes and Abdominal Pain
Part Ten Genetically Inherited Disorders Case 34. Feed a Cold
Case 35. Acute Neonatal Ammonia Intoxication
Case 36. Not Just a Picky Eater
Case 37. The “Fussy” Neonate
Case 38. The “Sleepy” Neonate
Case 39. A Happy but Developmentally Delayed 5-Year-Old Boy
Case 40. The Asymptomatic Iron Man
Case 41. Tired, Hot, and Lumpy
Case 42. A Rash on the Soles of the Feet
Case 43. When Life Gives You Lemons
Case 44. The Wheezing Woodsman
Case 45. Not Just Heartburn
Case 46. The Dangers of Yardwork
Case 47. An Important Finding on Routine Screening
Case 48. Increasing Abdominal Girth
Case 49. To Screen or Not to Screen?
Case 50. A Male with Confusing hCG Results
Case 51. Size Greater than Dates
Part Thirteen Hematologic Malignancies
Case 52. A Man with Anemia and Lymphocytosis
Case 53. A Teenager with Pneumonia, Leukopenia, and Ecchymoses
Case 54. A Middle-Aged Man with Chronic Foot Ulcer
Case 55. A Man with Progressive Effort Intolerance and Splenomegaly
Case 56. A Man with Splenic Vein Thrombosis and Polycythemia
Part Fourteen Benign Hematologic Disorders
Case 57. A Child with Pneumonia
Case 58. A Man with a Tender Toe and Anemia
Case 59. A Woman with Fatigue and Pallor
Case 60. Pulseless Leg 9 Days after a Myocardial Infarction
Case 61. Young Girl with a Bloody Knee Effusion
Case 62. A Young Man with Chest Pain Following a Knee Injury
Case 63. A Young Woman with Postpartum Cerebral Venous Thrombosis and Abnormal Coagulation Tests
Case 64. A Baby with Petechiae and Bruises
Case 65. Evaluation of a Reference Range Outlier
Case 66. A Woman with Abdominal
Pain and Thrombocytopenia
Case 67. Sudden Jaundice and Painful Fingers
Case 68. The Good in “Bad” Fish Tacos
Case 69. The Jaundiced Mother
Part Fifteen Porphyrias
Case 70. Young Woman with Recurrent Abdominal Pain
Case 71. A 9-Year-Old Boy with Skin Lesions and Headaches
Part Sixteen Pharmacogenomics
Case 72. Personalized Medicine for a Renal Transplant Patient
Case 73. Personalized Medicine for Pain Management
Case 74. A Man with Colitis and Pancytopenia
Case 75. A 46-Year-Old Female with a Painful, Swollen Right Calf
Part Seventeen Toxicology
Case 76. A Case of Mixed Club Drugs Abuse
Case 77. A 43-Year-Old Male with Chronic Pain
Case 78. Metabolic Acidosis of Unknown Origin Among Burn Patients
Part Eighteen Lipid Disorders
Case 79. The Family Reunion Party
Case 80. A 5-Year-Old Boy with Yellow-Orange Tonsils: Hypoalphalipoproteinemia
Case 81. Worsening Diarrhea in a 5-Year-Old Girl
Case 82. A 4-Year-Old Girl with Yellow Xanthomas and Arthritis
Part Nineteen Autoimmune Diseases
Case 83. Woman with Morning Stiffness and Tender, Swollen Joints
Case 84. Woman with a Rash and Lower Extremity Pain
Case 85. Woman with Diarrhea and Anemia
Part Twenty Analytical Errors
Case 86. Where’s My Baby?
Case 87. Elevated Concentrations, but Not Elevated Enough
Case 88. I Want To Go Home!
Case 89. Is That Really the Calcium Value?
Part Twenty-One Miscellaneous
Case 90. A Man with Fever and Acute Polyarthritis
Case 91. Middle-Aged Alcoholic with Jaundice and Ascites
Case 92. Where Did the Red Cells Go?
Index

Book Details

Paperback: 704 pages
Publisher: Wiley-Liss; 2 edition
Language: English
ISBN-10: 0471714577
ISBN-13: 978-0471714576
Product Dimensions: 9.7 x 6.8 x 1.4 inches

List Price: $89.95

Introduction to Microbiology

2011-04-25T02:26:00.000-07:00

Microorganisms can be found in every ecosystem and in close association with every type of multicellular organism. They populate the healthy human body by the billions as benign passengers (normal flora) and even as participants in bodily functions, for example, bacteria play a role in the degradation of intestinal contents. The role of microorganisms -bacteria, fungi, protozoa, helminths, and viruses- in the initiation and spread of human diseases. Those relatively few species of microorganisms that are harmful to humans, either by production of toxic compounds or by direct infection, are characterized as pathogens.

Most infectious disease is initiated by colonization (that is, the establishment of proliferating microorganisms on the skin or mucous membranes). The major exceptions are diseases caused by introduction of organisms directly into the bloodstream or internal organs. Microbial colonization may result in:

1) elimination of the microorganism without affecting the host, or

2) infection in which the organisms multiply and cause the host to react by making an immune or other type of response. Infectious disease occurs when the organism causes tissue damage and impairment of body function.

Prokaryotic Pathogens

All prokaryotic organisms are classified as bacteria, whereas eukaryotic organisms include fungi, protozoa, and helminths, as well as humans. Prokaryotic organisms are divided into two major groups: the eubacteria, which include all bacteria of medical importance, and the archaebacteria, a collection of evolutionarily distinct organisms. Cells of prokaryotic and eukaryotic organisms differ in several significant structural features.

A. Typical bacteria

Most bacteria have shapes that can be described as either a rod, sphere, or corkscrew. Prokarytoic cells are smaller than eukaryotic cells. Nearly all bacteria, with the exception of the mycoplasma, have a rigid cell wall surrounding the cell membrane that determines the shape of the organism. The cell wall also determines whether the bacterium is classified as gram-positive or gram-negative. External to the cell wall may be flagella, pili, and/or a capsule. Bacterial cells divide by binary fission. However, many bacteria exchange genetic information carried on plasmids' small, specialized genetic elements capable of self-replicationâ€”including the information necessary for establishment of antibiotic-resistance.

B. Atypical bacteria

Atypical bacteria include groups of organisms such as Mycoplasma, Chlamydia, and Rickettsia that, although prokaryotic, lack significant characteristic structural components or metabolic capabilities that separate them from the larger group of typical bacteria.

Fungi

Fungi are nonphotosynthetic, generally saprophytic, eukaryotic organisms. Some fungi are filamentous, and are commonly called molds, whereas others "the yeasts" are unicellular. Fungal reproduction may be asexual, sexual, or both, and all fungi produce spores. Pathogenic fungi can cause diseases, ranging from skin infections (superficial mycoses) to serious, systemic infections (deep mycoses).

Protozoa

Protozoa are single-celled, nonphotosynthetic, eukaryotic organisms that come in various shapes and sizes. Many protozoa are free-living, but others are among the most clinically important parasites of humans. Members of this group infect all major tissues and organs of the body. They can be intracellular parasites, or extracellular parasites in the blood, urogenital region, or intestine. Transmission is generally by ingestion of an infective stage of the parasite or by insect bite.

Helminths

Helminths are groups of worms that live as parasites. They are multicellular, eukaryotic organisms with complex body organization. They are divided into three main groups: tapeworms (cestodes), flukes (trematodes), and roundworms (nematodes). Helminths are parasitic, receiving nutrients by ingesting or absorbing digestive contents, or ingesting or absorbing body fluids or tissues. Almost any organ in the body can be parasitized.

Viruses

Viruses are obligate intracellular parasites that do not have a cellular structure. Rather, a virus consists of molecule(s) of DNA (DNA virus) or RNA (RNA virus), but not both, surrounded by a protein coat. A virus may also have an envelope derived from the plasma membrane of the host cell from which the virus is released. Viruses contain the genetic information necessary for directing their own replication, but require the host's cellular structures and enzymatic machinery to complete the process of their own reproduction. The fate of the host cell following viral infection ranges from rapid lysis releasing many progeny virions, to gradual, prolonged release of viral particles.

Mathematical and Statistical Estimation Approaches in Epidemiology

2011-04-24T09:14:00.000-07:00

Mathematical and Statistical Estimation Approaches in Epidemiology compiles theoretical and practical contributions of experts in the analysis of infectious disease epidemics in a single volume. Recent collections have focused in the analyses and simulation of deterministic and stochastic models whose aim is to identify and rank epidemiological and social mechanisms responsible for disease transmission. The contributions in this volume focus on the connections between models and disease data with emphasis on the application of mathematical and statistical approaches that quantify model and data uncertainty.
The book is aimed at public health experts, applied mathematicians and scientists in the life and social sciences, particularly graduate or advanced undergraduate students, who are interested not only in building and connecting models to data but also in applying and developing methods that quantify uncertainty in the context of infectious diseases. Chowell and Brauer open this volume with an overview of the classical disease transmission models of Kermack-McKendrick including extensions that account for increased levels of epidemiological heterogeneity. Their theoretical tour is followed by the introduction of a simple methodology for the estimation of, the basic reproduction number, R0. The use of this methodology is illustrated, using regional data for 1918–1919 and 1968 influenza pandemics.
This chapter is followed by Greenwood and Gordillo’s introduction to an analogous probabilistic framework. The emphasis is now on the computation of the distribution of the final epidemic size and the quantification of stochastically sustained oscillations. Next, the differences between observable and unobservable events in infectious disease epidemiology and their relationship to rigorous contact tracing and microbiological methodology are discussed in Chapter 3 by Nishiura et al. Furthermore, concepts like “dependent happening” and their role in identifying sources of infectious disease risk or in assessing vaccine efficacy are also discussed. In Chapter 4, Tennenbaum’s engages us in a discussion of modeling perspectives and approaches through his discussion of the meaning of “contact”. He challenges the reader to come up with novel approaches that bring together “ignored” biological and mechanistic aspects of the infection process.
Chapter 5 (Nishiura and Chowell) and Chapter 7 (Bettencourt) focus on real-time assessments of the reproduction number. The exposition is spiced with references to recent epidemic outbreaks. For example, Bettencourt uses his framework to estimate disease epidemiological parameters and to assess the effects of interventions in real time using data from the 2005 outbreak of Marburg hemorrhagic fever in Angola.
In Chapter 8, Burr and colleagues review the theoretical and practical challenges associated with biosurveillance including the detection of disease outbreaks using traditional diagnosed case rates or syndromic surveillance data. In Chapter 6, Lloyd notes that parameter estimates are subject to uncertainty that arise not only from errors (noise) in the data but also from the structure of the model used in the fitting process. In other words, he argues that uncertainty must be evaluated at multiple levels to account for our ignorance or for the balance that each modeler must reach between biological detail and model complexity and objectives. Parameter estimation, Lloyd argues, must include structural sensitivity analyses. The use of historical data in epidemiological research is highlighted in Chapter 9 by Acu˜na-Soto’s contribution.
As he notes epidemiologists are reluctant to consider systematically the possibility of working with historical data albeit, as we have seen in the first Chapter, it is possible to extract valuable information from such data on influenza outbreaks. In fact, we acquired the kind of quantitative knowledge that let us quantify some of the differences between seasonal and pandemic influenza. Acu˜na-Soto’s work1, for example, on the epidemic of 1576 that killed 45% of the entire population of Mexico, highlights but a myriad of new possibilities for which the quantitative methods and approaches highlighted in this book can be put to good use.
Banks and colleagues in Chapter 11 provide a succinct overview of the statistical and computational aspects associated with inverse or parameter estimation problems for deterministic dynamical systems. Their results illustrate the impact that the marriage between statistical theory and applied mathematics is having in the study of infectious diseases while Chapter 10 (Arriola and Hyman) provides a general and thorough introduction to the field of sensitivity and uncertainty analyses, a central piece of any scientific work that is based on modeling.
The challenges and opportunities generated by studies of disease outbreak or disease dynamics in specific contexts are highlighted in the final chapters. Shim and Castillo-Chavez (Chapter 12) evaluate the potential impact that ongoing agedependent vaccination strategies (in the United States and Mexico) are likely to have in reducing the prevalence of severe rotavirus infections. Rios-Doria et al.
(Chapter 13) analyze the spatial and temporal dynamics of rubella in Peru, 1997–2006 via a wavelet time series analysis and other methods. The study is carried out in the context of changing policies that include the introduction of a vaccine and/or increases in vaccination rates. Cintron-Arias and colleagues (Chapter 15) model drinking as a “communicable” disease and, in the process, they highlight a new set of opportunities and possibilities for the applications of the mathematical and statistical approaches used in this volume. The focus here is on the evaluation of the role of relapse (ineffective treatment) on drinking dynamics but as a function of social network heterogeneity.

Contents

The Basic Reproduction Number of Infectious Diseases: Computation and Estimation Using Compartmental Epidemic Models
Stochastic Epidemic Modeling
Two Critical Issues in Quantitative Modeling of Communicable Diseases: Inference of Unobservables and Dependent Happening
The Chain of Infection, Contacts, and Model Parametrization
The Effective Reproduction Number as a Prelude to Statistical Estimation of Time-Dependent Epidemic Trends
Sensitivity of Model-Based Epidemiological Parameter Estimation to Model Assumptions
An Ensemble Trajectory Method for Real-Time Modeling and Prediction of Unfolding Epidemics: Analysis of the 2005 Marburg Fever Outbreak in Angola
Statistical Challenges in BioSurveillance
Death Records from Historical Archives: A Valuable Source of Epidemiological Information
Sensitivity Analysis for Uncertainty Quantification in Mathematical Models
An Inverse Problem Statistical Methodology Summary
The Epidemiological Impact of Rotavirus Vaccination Programs in the United States and Mexico
Spatial and Temporal Dynamics of Rubella in Peru, 1997–2006: Geographic Patterns, Age at Infection and Estimation of Transmissibility
The Role of Nonlinear Relapse on Contagion Amongst Drinking Communities
Index

Product Details

Authors: Gerardo Chowell, James M. Hayman, Luís M. A. Bettencourt and Carlos Castillo-Chavez
Hardcover: 384 pages
Publisher: Springer; 1 edition (June 25, 2009)
Language: English
ISBN-10: 9048123127
ISBN-13: 978-9048123124
Product Dimensions: 9.5 x 6.3 x 1.2 inches

List Price: $189.00

Glasser: Essentials of Clinical Research

2011-04-23T02:07:00.000-07:00

Part I : This Part addresses traditional clinical research, beginning with the history of the development of clinical research, to traditional clinical research designs, with a focus on clinical trials. It includes a discussion of the role of the USFDA in clinical trials and the placebo response, data safety and monitoring boards, and meta-analysis.
Part II : This Part deals with some of the newer approaches in clinical research, specifically research methods for genetic studies, diagnostic testing studies, and pharmacoepidemiology studies. This Part concludes with a chapter that addresses a newer field of Implementation Research – that is, how to implement the research findings that are published, into everyday practice.
Part III : This Part addresses statistical concepts important for the clinical researcher. It is not a Part that is for statisticians, but rather approaches statistics from a basic foundation standpoint.
Part IV : Now that the research has been done, how is it presented? That is, how is it presented to the media and to colleagues? This Part also discusses the mentoring process that is necessary for the optimal development of a junior faculty member into an independent researcher.

Contents
Part I
1 Clinical Research: Definitions, “Anatomy and Physiology,” and the Quest for “Universal Truth”
2 Introduction to Clinical Research and Study Designs
3 Clinical Trials
4 Alternative Interventional Study Designs
5 Postmarketing Research
6 The United States Federal Drug Administration (FDA) and Clinical Research
7 The Placebo and Nocebo Effect
8 Recruitment and Retention
9 Data Safety and Monitoring Boards (DSMBs)
10 Meta-Analysis
Part II
11 Research Methods for Genetic Studies
12 Research Methods for Pharmacoepidemiology Studies
13 Implementation Research: Beyond the Traditional Randomized Controlled Trial
14 Research Methodology for Studies of Diagnostic Tests
Part III
15 Statistical Power and Sample Size: Some Fundamentals for Clinician Researchers
16 Association, Cause, and Correlation
17 Bias, Confounding, and Effect Modification
18 It’s All About Uncertainty
19 Grant Writing
Part IV
20 The Media and Clinical Research
21 Mentoring and Advising
22 Presentation Skills: How to Present Research Results
Index

Product Details

Hardcover: 376 pages
Publisher: Springer; 1 edition (September 10, 2008)
Language: English
ISBN-10: 1402084854
ISBN-13: 978-1402084850
Product Dimensions: 9.3 x 6.4 x 0.8 inches

List Price: $79.95

Joshep: Diagnostic Neuropathology Smears

2011-04-22T01:59:00.000-07:00

This text makes no attempt to cover the material of the excellent text by Burger, Scheithauer, and Vogel, Surgical Pathology of the Nervous System and Its Coverings; all who are serious about surgical neuropathology should obtain it. Nor does this text cover every rare or esoteric disease and tumor; it only discusses those entities likely to confront the pathologist in the 'frozen room.' The purpose of this treatise is to present the power of smears in neuropathology, both its utility in making 'frozen section' diagnoses and its unique ability to give biologically relevant structural information about brain lesions.
All books, really all forms of communication, require an audience. The audience for this text includes anyone interested in brain tumors. It will be especially useful for pathologists who need to make intraoperative or 'frozen section' diagnoses in neurosurgical cases. It would also be useful to residents trying to learn more about neuropathology, as well as any physician who is interested in using smears as a diagnostic tool. The early sections and the chapter on metastases apply to general aspects of anatomic pathology, while the central chapters deal with topics relevant to the surgical neurology patient.
Product Details

Hardcover: 256 pages
Publisher: Lippincott Williams & Wilkins; 1 edition
Language: English
ISBN-10: 0781786479
ISBN-13: 978-0781786478
Product Dimensions: 10.9 x 8.6 x 0.6 inches

List Price: $163.95

Lednicer: Steroid Chemistry at a Glance

2011-04-21T01:05:00.000-07:00

The term ‘steroid’ has become virtually synonymous with androgenic–anabolic compounds (mainly analogues of testosterone) to the majority of the public. The sport sections of many newspapers carry almost daily exposses of the usage of these drugs by athletes seeking to enhance their performance. The androgens in question, however, comprise only a single, relatively small, class of biologically active steroids. What may be called the athletic androgens are in reality overshadowed by a large universe of compounds that share the same tetracyclic nucleus. The term ‘androgen’ in fact represents only one-tenth of the hits when Googling the term ‘steroid’. The very sizeable number of steroids that are approved by regulatory agencies as therapeutic drugs eclipses the group of legal androgenic–anabolic drugs.
By the 1940s, about a decade after their structure had been firmly established, it became evident that steroids might well comprise a structural lead for drug design. Preliminary results from pharmacological studies, carried out at that time, suggested that selected steroids could potentially lead to drugs aimed at targets as diverse as oral contraceptives on the one hand and inflammation on the other. The potential markets for such drugs spurred major chemical efforts in industrial and to some extent in academic laboratories. Research that led to steroid-based therapeutic agents was carried out largely in the laboratories of ‘Big Pharma’ over the two decades following the end ofWorldWar 2. This resulted in the accretion of a large body of organic chemistry often denoted ‘Steroid Chemistry’, and also a sizable number of new therapeutic agents. The assignment of a USAN designation, more familiarly known as a generic name, to a potential drug indicates that the sponsor intends to take the initial steps to assess the clinical activity of the compound. Close to 130 steroids have been assigned official USAN non-proprietary names.
Reports of side-effects that accumulated as the drugs became more widely used led chemists to go back to modify the structures of the offending agent in the hope of producing better tolerated entities. It would be nai¨ve to dismiss the aim of obtaining a place in the market by means of one’s own proprietary and patented entity as additional motivation for that task. It became evident by the mid-1970s that many of the undesired properties, that is, side-effects, were often simply another aspect of the desired hormonal activity. Research aimed at novel steroid-based drugs consequently decreased markedly. The preceding chemical research in the area had by the accumulated a significant body of specialized reactions.
All steroids, be they derived from natural sources or produced by total synthesis, share the same rigid, fixed, three dimensional framework. Many of the chemical properties of steroids, such as the dependence of the reactivity of functional groups on their specific location, are determined by steric properties of the steroid nucleus. That nucleus incorporates over half a dozen chiral centers not counting the side chain. Cholesterol, for example, can in theory consist of no fewer than 512 stereoisomers. This compound actually occurs as a single chiral species, as do virtually all other steroid-based products. The chemistry of these compounds thus provides a rich source for the study of the effects of stereochemistry on chemical reactivity. The reactivity of a pair of ketones in the same molecule, for example, will often differ markedly due to differences in their steric milieu. Structural features of steroids generally determine biological activity. Steroids with an aromatic A ring will, for example, act as estrogens. Differing structural features found in each of those groups has a marked influence on the reactions and reaction sequences used in preparing potential drugs. A text on steroid chemistry could in theory be organized either on the basis of reactions or alternatively by structural class. Grouping compounds by reaction-based sections it is felt would lead to somewhat jumbled presentations. Many of the organic reaction schemes in used steroid chemistry are characteristic of one or another of the broad structural classes. This volume is accordingly divided into the traditional broad structural chapters. The circumstance that biological activity follows the same organization merely illustrates the concordance of structure and activity.
Rules of nomenclature appear early on in many beginning organic chemistry texts. In somewhat the same vein, the Introduction to this book starts with the conventions for naming steroids. This is followed by a concise account of the molecular mechanism of action by which many steroids exert their biological effects. More detailed descriptions of the activity of these compounds will be found in the opening paragraphs of the individual structural classes. Chapter 1 describes the history of steroids with particular attention to the research aimed defining the chemical structure of what were at the time fairly complex molecules. The reader may find it convenient to skim over this section at first reading and to then return after acquiring more familiarity with steroid chemistry.
Chapter 2 opens with a description of the biosynthesis of naturally occurring steroids. The conversion of two very different phytochemicals to steroids that can be elaborated to potential drugs follows. The narrative focuses on a discussion of the chemistry whereby these steroidal natural products are modified into steroid starting materials. Specifically, this describes first the chemistry used to convert diosgenin from Mexican yam roots to dehydropregnenolone and then a discussion of the preparation of pregnenolone from stigmasterol obtained from soybeans. Chemical manipulations of aromatic A-ring steroids, the estranes, are described in Chapter 3. The relative simplicity of the structure of estranes has led to the development of close to half a dozen syntheses that differ in approach, starting from laboratory chemicals. One of these total syntheses, in contrast to those found in subsequent chapters, is used in actual practice to prepare intermediates for the gonanes discussed in Chapter 4. There follows a description of the process long used to prepare aromatic A-ring steroids from phytochemical-derived sources. Chemical reactions of estranes close this chapter.
The chemistry of gonanes, more familiarly known as 19-nor steroids, constitutes the subject matter of Chapter 4. This chapter opens with a discussion the general methods used to prepare the gonane nucleus. Those methods include two syntheses starting from laboratory chemicals that differ markedly in their approach. The description of the chemistry of the gonanes is divided according the disparate biological activity structural variants. These comprise a section on compounds that act as androgenic–anabolic agents and another that includes progestational agents. This last section includes most of the oral contraceptives. A discussion of the newer 11-arylgonane progesterone antagonist concludes Chapter 4.
The androstanes, often called C-19 steroids in that they include methyl groups at each of the angular carbons at C10 and C13, are described in Chapter 6. This section, like the preceding one, also starts with a description of the chemistry used to provide starting material. It also includes a discussion of a total synthesis based on an electrocyclic reaction. The bulk of the chapter comprises of a ring-by-ring description of the chemistry that has been used to prepare modified C-19 androstanes. The bulk of the compounds in this first part of the chapter exhibit androgenic-anabolic activity. Incorporation of a spirobutyrolactone at C17 of the C-19 androstanes leads to compounds that act as diuretics as a result of their aldosterone blocking activity. A brief section on those compounds completes Chapter 5.
Pregnanes in essence comprise androstanes that in addition feature a two-carbon side chain, almost exclusively acetyl, at C17. This carbon skeleton is common to both progestins and corticosteroids. Chapter 6 is devoted to a discussion of the chemistry used to prepare derivatives of the simpler of the two, progesterone. Sources of starting materials for modified progestins from both diosgenin and stigmasterol are discussed at the beginning of the chapter. This is followed by a total synthesis that includes a cascade electrocyclization reaction that somewhat resembles the biosynthetic process by which squalane goes to lanosterol. There follows a ring-by-ring examination of the chemistry used to modify the basic pregnane nucleus.
Structurally more complex corticosteroids, commonly called corticoids, are grouped in Chapter 7, the second section on pregnanes. The biological activity of this class of pregnanes depends on the presence of an oxygen atom, either as a ketone or as an alcohol, at C11 in ring C. The rarity of this structural feature in Nature placed high priority on developing methods for adding that feature to more abundant steroids from Nature. Chapter 7, as in the preceding chapter, opens with a discussion of the methods that have been developed for preparing the starting 11-oxypreganes required for both
clinical supplies and research on analogues. Methods for preparing analogues that include single modifications are considered first. Corticoids comprise one of the rare classes of compounds in which the potentiating effects of structural changes are additive. The closing sections of Chapter 7 discuss the chemistry for preparing compounds with multiple modification.
Groups of steroids that are too small for a full chapter are to be found in the seemingly inevitable chapter termed Miscellaneous. The first section considers steroids in which one of the ring carbon atoms is replaced by a heteroatom, more specifically oxygen or nitrogen. Two compounds in this class, both androstanes, are approved for use in humans. Cardenolides, the steroid-based compounds obtained on removal of the sugars from the so-called cardiac glycosides, are considered in the next section. The chapter closes with a brief discussion of the chemistry involved in modifying the unsaturated cholestanes related to vitamin D.

Contents
1 Steroids: a Brief History 10
1.1 Structure Determination 10
1.1.1 Cholesterol and Cholic Acid 10
1.1.2 The Sex Steroids 13
1.1.3 Corticosteroids 16
2 Sources of Steroids 20
2.1 Biosynthesis 20
2.2 Commercial Steroid Starting Materials 22
2.2.1 Diosgenin 23
2.2.2 Soybean Sterols 25
3 Estranes: Steroids in Which Ring A is Aromatic 28
3.1 Biological Activity 28
3.2 Sources of Estranes 28
3.2.1 From Androstanes 28
3.2.2 Estrogens by Total Synthesis 32
3.3 Chemical Reactions of Estranes 37
3.3.1 Aromatic A-ring Reactions 37
3.3.2 Modifications on Ring B 40
3.3.3 Modifications on Ring C 41
3.3.4 Modifications on Ring D 42
3.4. Some Drugs Based on Estranes 45
4 Gonanes or 19-nor-Steroids 48
4.1 Preparation of Gonane Starting Materials 48
4.1.1 Birch Reduction 48
4.1.2 Synthesis by Sequential Annulation Reactions 49
4.2 Anabolic–Androgenic Gonanes 50
4.2.1 Biological Activity 50
4.2.2 Synthesis of 19-Norandrogens 51
4.3 Progestational Gonanes 55
4.3.1 Biological Activity 55
4.3.2 Preparation of 19-Norprogestins 55
4.4 Some Drugs Based on Gonanes 67
4.4.1 Androgenic–Anabolic Agents 67
4.4.2 Progestins 67
4.4.3 Progestin Antagonists 67
5 Androstanes, C19 Steroids and Their Derivatives 68
5.1 Biological Activity 68
5.2 Sources of Androstanes 68
5.2.1 From Pregnenolone 68
5.2.2 Fermentations 69
5.2.3 Total Synthesis 69
5.3 Modified Anabolic–Androgenic Androstanes 69
5.3.1 17-Desalkyl Compounds 69
5.3.2 17-Alkyl Compounds 73
5.3.3 Modifications on Ring B 77
5.3.4 Modifications on Ring C 79
5.3.5 Modifications on Ring D 80
5.4 17-Spirobutyrolactone Aldosterone Antagonists 83
5.5 Some Drugs Based on Androstanes 85
5.5.1 Androgens 85
5.5.2 Spirobutyrolactones 85
6 Pregnanes, Part 1: Progestins 86
6.1 Biological Activity 86
6.2 Sources of Progesterone 86
6.2.1 From Phytochemicals 86
6.2.2 By Total Synthesis 87
6.2.3 From Dehydroepiandrosterone (DHEA) Acetate 88
6.3 Modified Pregnanes 88
6.3.1 17-Hydroxy and Acyloxy Derivatives 88
6.3.2 Modifications on Ring A 89
6.3.3 Modifications on Ring B 90
6.3.4 General Methods for Modifications on Ring D 94
6.3.5 More Progesterone Analogues 96
6.4 Some Drugs Based on Progestins 100
6.4.1 Medroxyprogesterone Acetate (10-2) 100
6.4.2 Megestrol Acetate (10-3) 101
6.4.3 Melengestrol Acetate (26-7) 101
7 Pregnanes, Part 2: Corticosteroids 102
7.1 Biological Activity 102
7.2 Sources of Corticoids 102
7.2.1. Introduction of Oxygen at C11 102
7.2.2 Construction of the Dihydroxyacetone Side Chain 103
7.3 Modified Corticoids 105
7.3.1 Unsaturation 105
7.3.2 Additional Alkyl Groups 106
7.3.3 Halogenated Corticoids 109
7.3.4 Hydroxylation: 16,17-Diols 111
7.3.5 Corticoids with Multiple Modifications 112
7.3.6 Miscellaneous Corticoids 117
7.4 Some Drugs Based on Corticoids 119
8 Miscellaneous Steroids 122
8.1 Heterocyclic Steroids 122
8.1.1 Introduction 122
8.1.2 Steroids with a Heteroatom in Ring A 122
8.1.3 Steroids with a Heteroatom in Ring B 124
8.1.4 Steroids with a Heteroatom in Ring C 126
8.1.5 Steroids with a Heteroatom in Ring D 128
8.2 Cardenolides 129
8.2.1 Actodigin Aglycone 130
8.2.2 Synthesis from a Bile Acid 130
8.3 Compounds Related to Cholesterol 132
Subject Index 135
Reactions Index 141

Book Details

Paperback: 152 pages
Publisher: Wiley (December 28, 2010)
Language: English
ISBN-10: 0470660848
ISBN-13: 978-0470660843
Product Dimensions: 11.6 x 8.1 x 0.5 inches

List Price: $49.95

Stevens: Clinical Immunology and Serology: A Laboratory Perspective 3rd Edition

2011-04-17T09:39:00.000-07:00

The third edition of Clinical Immunology and Serology: A Laboratory Perspective is built on the success of the first two editions. This text is tailored to meet the needs of clinical laboratory students on both the two and four year levels. It combines practical information about laboratory testing with a concise discussion of the theory behind the testing.
For practicing laboratorians and other allied health professionals, the book may serve as a valuable reference about new developments in the field of immunology. All chapters have been updated to include new information about the immune system as well as new treatments for immunological diseases. Two new chapters have been added. They include: automated assays, emphasizing flow cytometry (Chapter 12), and serology of bacterial infections (Chapter 19). The chapter on fungal and parasitic infections has beenexpanded (Chapter 20), as well as the chapter on molecular techniques (Chapter 19). All the features that readers enjoyed have been retained and strengthened. The number of illustrations has increased, and new case studies have been added.
The book remains a practical introduction to the field of clinical immunology that combines essential theoretic principles with serologic techniques commonly used in the clinical laboratory. The theory is comprehensive but concise, and the emphasis is on direct application to the clinical laboratory. The text is readable and user-friendly, with learning objectives, chapter outlines, and a glossary of all key terms. Each chapter is a complete learning module that contains theoretic principles, illustrations, definitions of relevant terminology, procedures for simulated clinical testing, and questions and case studies that help to evaluate learning.
The organization of the chapters is based on the experience of many years of teaching immunology to clinical laboratory science students. This book has been designed to provide the necessary balance of theory with practical application because it is essential for the practitioner to have a thorough understanding of the theoretic basis for testing methodologies. For the instructor, suggested laboratory exercises are included where applicable. While some of the exercises are not used in an actual clinical laboratory, they serve to illustrate and reinforce principles discussed in the chapters. Since most clinical laboratory science programs do not have extensive technology available in the academic setting, exercises have been designed to be performed with minimal equipment. Because the field of immunology is expanding so rapidly, the challenge in writing this book has been to ensure adequate coverage but to keep it on an introductory level. Every chapter has been revised to include current practices as of the time of writing. It is hoped that this book will kindle an interest in both students and laboratory professionals in this exciting and dynamic field.

Contents
Section I: Nature of the Immune System
Chapter 1: Introduction and Natural Immunity
Chapter 2: The Lymphoid System
Chapter 3: Nature of Antigens and Major Histocompatibility Complex
Chapter 4: Antibody Structure and Function
Chapter 5: Cytokines
Chapter 6: Complement System
Section II: Basic Immunological Procedures
Chapter 7: Safety and Specimen Preparation
Chapter 8: Precipitation Reactions
Chapter 9: Agglutination
Chapter 10: Labeled Immunoassays
Chapter 11: Molecular Diagnostic Techniques
Chapter 12: Flow Cytometry and Laboratory Automation
Section III: Immune Disorders
Chapter 13: Hypersensitivity
Chapter 14: Autoimmunity
Chapter 15: Immunoproliferative Diseases
Chapter 16: Immunodeficiency Disease
Chapter 17: Transplantation Immunology
Chapter 18: Tumor Immunology
Section IV: Serological Diagnosis of Infectious Disease
Chapter 19: Serologic and Molecular Detection of Bacterial Infections
Chapter 20: Serology of Parasitic and Fungal Infections
Chapter 21: Spirochete Diseases
Chapter 22: Serology and Molecular Detection of Viral Infections
Chapter 23: Laboratory Diagnosis of HIV Infection
Glossary
Answer Key
Index

Product Details

Paperback: 454 pages
Publisher: F.A. Davis Company; 3 edition (August 31, 2009)
Language: English
ISBN-10: 080361814X
ISBN-13: 978-0803618145
Product Dimensions: 10.7 x 8.4 x 1 inches

List Price: $62.95

Jablonski's Dictionary of Medical Acronyms and Abbreviations 6th Edition

2011-04-16T09:36:00.000-07:00

This sixth edition of Jablonski's Dictionary of Medical Acronyms & Abbreviations is the first to be published without the tireless work of Stanley Jablonski, who passed away just before the publication of the fifth edition. The book has been extremely well received over the years, and the author's enthusiasm and love of medical vocabulary in all its forms, even maddeningly obscure abbreviations, are evident in its pages. The task of maintaining this volume now falls to the staff of the Dorland's dictionaries, who are well aware of the tradition of excellence that they have inherited.
Although responsibility for maintaining the text has changed, the book itself remains the familiar, convenient little volume that has served users well for two decades. The book retains its format of boldface abbreviations followed by run-in meanings, a device that enables it to encompass as many entries as larger, heavier books in an easyto-handle size. The list of symbols, which has been expanded for this edition, is in its usual place at the front of the book. The listings for organizations have been updated: new ones have been added; name changes have been incorporated; outdated names have been cross-referenced to new ones (or dropped, when thoroughly obsolete, to make room for new material). Abbreviations and acronyms are included in a single alphabetically arranged section (no need to flip through multiple sections) and several thousand new entries have been added. The CD-ROM that accompanies this book has been improved from that of the previous edition—it is searchable for both abbreviations and meanings, which will greatly increase its usefulness.
As has been noted by many, the convenience of using acronyms and abbreviations can be outweighed by the danger in doing so. In some cases, ambiguity in interpretation can lead to situations in which patient safety may be compromised. For this reason, the Joint Commission (JCAHO) has created a list of abbreviations that are considered dangerous and should not be used in a health care setting. The abbreviations included in this edition have been compared with the JCAHO "Do not use" list, and those that occur on this list are so identified.

Product Details

Paperback: 544 pages
Publisher: Saunders; 6 edition (October 23, 2008)
Language: English
ISBN-10: 1416058990
ISBN-13: 978-1416058991
Product Dimensions: 7.4 x 4.9 x 0.9 inches

List Price: $36.95

Hepatitis Delta Virus (Current Topics in Microbiology and Immunology)

2011-04-15T07:31:00.000-07:00

Since its discovery nearly 30 years ago, hepatitis delta virus (HDV) has continued to surprise and fascinate. Initially thought to be an antigenic variant of hepatitis B virus (HBV), HDV was soon found to be a defective virus that depends on an underlying or simultaneous hepatitis B infection. The clinical significance of HDV infection is more severe acute and chronic liver disease than that caused by the HBV infection alone. The cloning and sequencing of the genome led to the realization that HDV is a unique RNA virus whose closest known relatives are plant viroids, but even that relationship is remote. In the current classification scheme of the International Congress on the Taxonomy ofViruses,HDV remains the sole member of a floating genus, Deltavirus. The genome and its replication cycle bear no discernable resemblance to its helper virus, HBV, on which HDV depends for its envelope.
At 1,680 nucleotides the HDV genome is the smallest known to infect man. The virus contains just one gene, which encodes an approximately 2 -kDa protein, hepatitis delta antigen (HDAg, also sometimes referred to as delta protein or delta antigen). To compensate for this limited protein coding capacity,HDV relies heavily on host functions and on the structural dynamics of its circular RNA genome.
Although HDV RNA is circular, it forms a characteristic unbranched rod structure inwhich over 70% of the nucleotides fromWatson–Crick base pairs. One of themore remarkable aspects ofHDV is that, unlike other RNA viruses, it does not produce a virally-encoded polymerase; rather, it somehow uses host DNA-dependent RNA polymerase to replicate its RNA genome and transcribe its mRNA. At a minimum, this process involves RNA polymerase II; HDAg also plays an as yet undefined role. The potential involvement of another polymerase, such as polymerase I, or of other forms of RNA polymerase II remains an area of active investigation. RNA replication requires the unbranched rod structure of HDV RNA and occurs via a double rolling circle mechanism. Autocatalytic self-cleaving elements, termed ribozymes, in the genome and its complement, the antigenome, play essential roles in the processing of linear transcripts to circular forms. Ribozyme activity occurs via acid-base catalysis not unlike that accomplished by protein enzymes, and requires a complex double pseudoknot RNA structure. Ribozyme activity is also controlled by the structural dynamics of the RNA: formation of the unbranched rod structure interferes with ribozyme activity and likely prevents cleavage from occurring once the RNA circularized.
HDV produces two forms of HDAg that have different roles in the replication cycle. The longer form has an additional 19 or 20 C-terminal amino acids that facilitate viral particle formation; the shorter form is required for RNA replication. The heterogeneity arises due to highly specific editing of an adenosine in the antigenome RNA by host RNA adenosine deaminase. This process requires particular secondary structure features in the RNA around theeditingsite. Insome cases the unbranched rod structure competes with the configuration required for editing; thus, structural dynamics of the RNA are important not only forHDVribozyme activity, but for other processes as well. The functional activityofHDAg is affected by numerous post-translational modifications carried out by host enzymes. These modifications include farnesylation, phosphorylation, methylation and acetylation. Farnesylation is essential for interaction with the hepatitis B virus surface protein (HBsAg), and is thus required for viral particle formation. The specific significance of the other modifications, as well as the nature of their effects on HDAg function, are not yet fully understood.
Being derived from HBV proteins, the outside of the HDV particle is similar to that of HBV, only slightly smaller in size. Although the receptor for neither virus has been identified it is likely that attachment and entry occur by similar processes. Infectivity of both HBV and HDV involves elements of the preS1 and antigenic loop regions of HBsAg.
Molecular genetic analysis of HDV isolates indicates geographical correlations that in some ways mirror those of its helper virus. That the greatest sequence diversity is found among isolates originating in Africa has led to the proposal that HDV might have radiated from that continent. One enigma is that the most distantly related sequences, for both HDV and HBV, come from South America. There is some evidence that infection with certain genotypes, or clades, can influence the severity of HDV disease.
The mechanisms by which HDV thwarts the immune system to produce chronic infection are not yet understood. The woodchuck model of HDV has been the most accessible animal model of HDV infection and has been used both to analyze the natural history of HDV infection and to evaluate the efficacy of vaccine strategies against the virus. Certainly, development of an effective vaccine strategy has been frustrating. Recent work suggests that HDAg may be poorly immunogenic, and may furthermore undergo genetic changes to avoid those limited immune responses that do occur.
There are no effective licensed antiviral therapies for HDV, and although several therapies exist for combating its helper,HBV, none of these treatments affect HDV. This failure is due to the fact that HDV depends only on HBsAg production of the helper, and current anti-HBV therapies are not potent enough to significantly diminish HBsAg levels, which are extraordinarily high. However, two potential therapeutic approaches have shown promise. One targets the host farnesyltransferase activity, which is required for virus production; the other approach advocates reducing HBsAg to levels that are too low to support continued HDV secretion. Both of these approaches are based to varying degrees on an understanding of the molecular virology of HDV, and it is likely that additional therapeutic avenues will be opened as our knowledge of HDV expands.
This book will stimulate additional interest in hepatitis delta virus among scientists, academic researchers and advanced students.

List of Contents
Structure and Replication of Hepatitis Delta Virus RNA
HDV RNA Replication: AncientRelic or Primer?
HDV Ribozymes
RNA Editing in Hepatitis Delta Virus
Post-translational Modification of Delta Antigen of Hepatitis D Virus
The Role of the HBV Envelope Proteins in the HDV Replication Cycle
Prenylation of HDAg and Antiviral Drug Development
Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades?
Functional and Clinical Significance of Hepatitis D Virus Genotype II Infection
Immunology of HDV Infection
The Woodchuck Model of HDV Infection
Subject Index

Product Details

Hardcover: 228 pages
Publisher: Springer; 1 edition (June 14, 2006)
Language: English
ISBN-10: 3540298010
ISBN-13: 978-3540298014
Product Dimensions: 9.4 x 6.2 x 0.6 inches

List Price: $159.00

Paul: Fundamental Immunology 6th Edition

2011-04-14T07:33:00.000-07:00

Immunology is the quintessential medical science. Indeed, no branch of the medical sciences has improved the health of people more than the application of immunologic principles to prevention of disease. Smallpox has been eliminated from the planet as a natural infection, as has poliomyelitis from the Western Hemisphere. Hepatitis B vaccine has prevented more cancers than any intervention other than smoking cessation. The newly introduced human papilloma virus vaccine promises to cut strikingly the toll of cervical cancer.
The continued need for progress in immunology is clear. The HIV epidemic roars on. Disappointing results from vaccine trials require a redoubled effort to understand how to build the new generations of vaccines that can attack the really hard problems, including HIV, tuberculosis, and malaria, among infectious diseases. Highly effective therapeutic vaccines for cancers still elude us, but progress in understanding the innate immune system and regulatory T cells places new tools in our hands to continue the attack on this major problem.
Understanding the basis of inflammation and the cytokine world has given us effective drugs to treat rheumatoid arthritis and other autoinflammatory/autoimmune diseases. The value of the interventions based on this knowledge, such as the use of tumor necrosis factor (TNF), interleukin-6 (IL-6), and IL-1 blockers, is now established. The application of anti-CD20 in the treatment of autoimmune disorders shows great promise.
Fundamental Immunology has the goal of aiding in the education of a new generation of immunologists who can both probe more deeply into the organizing principles of the immune system and can translate this new information into effective treatments and preventatives that can extend and enlarge on the record of immunologic science in bettering the lot of humankind.
Were I beginning the task of preparing a comprehensive text of immunology today, I might have titled it Immunology, Endless Fascination. Certainly that describes my own view of this science over the more than 25 years that I have been working on the six editions of Fundamental Immunology. I had believed that scientific progress was marked by periods of intense creativity, during which new concepts were established, followed by longer periods of consolidation, when work that made important but anticipated advances would dominate. Perhaps that will prove to be true of modern immunology as well when it is looked at by a disinterested observer, but for one in the midst, the pace of discovery seems to speed up with each passing year. Endless fascination certainly describes my experience of immunology.
During the interval since the previous edition, there have been major advances in every field of immunology. Indeed, in one of the most striking pieces of work, an entirely new adaptive immune system has been discovered. Pancer, Cooper, and their colleagues have shown that jawless vertebrates, rather than using an adaptive immune system based on the immunoglobulin superfamily T-cell and B-cell receptors, evolved an entirely distinct adaptive system based on the use of leucine-rich repeat molecules as the recognition elements. The understanding of innate immunity continues to grow with the deepening understanding of the range of microbial sensors and of how they link to the adaptive immune system. The 2007 Lasker Prize for Basic Medical Sciences went to Ralph Steinman for his discovery of dendritic cells, which interpret the messages of the innate system to the adaptive system. The importance of regulatory T cells continues to grow, as does our insight into the mechanisms of their action. The cytokine biology field expands and broadens in its importance. The number of interleukins is now into the mid-30s, and some of the more recently discovered molecules have the most important functions. The application of imaging technologies that allow the visualization of the in vivo behavior of the cells and tissues of the immune system has provided spectacular insights into the structure and dynamics of the system and promises still more amazing results in the future. The field of systems immunology, still in its infancy, has given notice that it will be a major approach to our science in the next decades.
This sixth edition will convey this dynamism and provide the reader with both a solid grounding in our field and with much of the very latest that has been achieved. As with each of the previous editions, most of the chapters are entirely new and not simple reworkings of the chapter in the previous edition. In order to contain the sixth edition within one volume, a decision was made to limit the number of references that will be printed in the text. For those chapters in which there are substantially in excess of 200 references cited in the text, the authors have selected 200 to be included in the print version of the book. All are included in the electronic version. The electronic version can be accessed at www.fundamentalimmunology.com.

Product Details

Hardcover: 1632 pages
Publisher: Lippincott Williams & Wilkins; Sixth edition (May 22, 2008)
Language: English
ISBN-10: 0781765196
ISBN-13: 978-0781765190
Product Dimensions: 11.1 x 8.7 x 2 inches

List Price: $219.00

Hepatitis C Virus Disease: Immunobiology and Clinical Applications

2011-04-13T07:28:00.000-07:00

Hepatits C virus (HCV) infection represents a worldwide disseminated disease, but despite numerous studies, its pathogenesis and medical treatment have not been completely elucidated.
As far as HCV pathogenesis is concerned, HCV genotypes and viral antigens have been investigated with the aim to find a correlation with disease severity and response to treatment. On the other hand, according to current literature, immunological response is implicated in disease progression rather than in host protection. Finally, use of interferon (IFN)-alpha alone or in combination with other antiviral drugs, e.g., ribavirin (RIB), at the moment represents the most effective treatment in chronic HCV disease, even if the percentage of cured patients is still low.
On these grounds, the present book, entitled Hepatis C Virus Disease: Immunobiology and Clinical Applications, will emphasize the most recent advances in HCV infection, moving from basic research to clinical application. In particular, in the first chapters of this volume, the full spectrum of immune responses to HCV is analyzed,taking into account either innate or adoptive immunity involvement. In this respect, the role of antigen-presenting cells (macrophages and dendritic celsl) and Toll-like receptors and that of T helper, T cytotoxic, natural killer, and T regulatory cells will be discussed in the course of HCV disease.
At the same time, deficits of innate immunity at the peripheral level with an easier access of microbes into the host will be described also in view of a putative interference of microbial products with IFN trreatment. In the last part of this volume, a series of contributions elucidates the state of the art of IFN-alpha treatment in HCV patients and the effectiveness of therapy also in relation to HCV genotypes. Besides the combined treatment with IFN-alpha and RIB, the use and applications of pegylated IFNs aree the object of intensive speculation in specific chapters. Finally, the complicated HCV disease and its treatment are discussed.
In summary, this volume, written by various scientists with specific expertise in the field of HCV infection, should represent an efficacious up-to-date on the state of the art of HCV disease in diifferent geographical areas. Moreover, a clear description of disease pathogenesis, a detailed clarification of immune mechanisms, and a deep elucidation of the pharmacology of antiviral drugs should be very useful for a large readership, even including medical students who may wish to learn basic principles of HCV infection.

Contents
1 Innate Immunity in Type C Hepatitis
2 Mechanisms of Interferon Action and Resistance in Chronic Hepatitis C Virus Infection: Lessons Learned from Cell Culture Studies
3 Immunological Parameters Influencing Adaptive Immune Responses to the Hepatitis C Virus
4 Immune Responses Against the Hepatitis C Virus and the Outcome of Therapy
5 Other Microbial Components Associated with Hepatitis C Virus Infection: Their Effects on Interferon- a/Ribavirin Treatment
6 Interferon-Induced Effector Proteins and Hepatitis C Virus Replication
7 Treatment of Chronic Hepatitis C with Different Genotypes
8 Interferon Treatment of Hepatitis C Virus Infection: From Basic Biology to Clinical Application
9 Interferon-Based Therapy for Hepatitis C Virus Infections
10 Treatment of Chronic Hepatitis C in “Difficult-to-Treat” Patients in the Clinical Setting
11 Effects of Combined IFN-Alpha/Ribavirin Treatment in HCV Disease-Related Progression
12 Pegylated Interferons: Clinical Applications in the Management of Hepatitis C Infection
Subject Index

Product Details

Hardcover: 308 pages
Publisher: Springer; 1 edition (November 13, 2007)
Language: English
ISBN-10: 0387713751
ISBN-13: 978-0387713755
Product Dimensions: 9.3 x 6.3 x 0.8 inches

List Price: $129.00

Tank & Gest: Lippincott Williams & Wilkins Atlas of Anatomy

2011-04-12T10:43:00.000-07:00

The opportunity to create a new anatomical atlas could not be described as even a once-in-a-lifetime opportunity. Original atlases simply are not produced often enough to make that statement accurate. As anatomical educators of medical students with nearly 60 years of classroom experience between us, we are familiar with all of the anatomical atlases that are currently on the market, and it is a very esteemed group. Our experience with these existing atlases has helped us formulate strong ideas of how to present anatomical images more concisely and in a more logical sequence. The intent of this new atlas is to make images easier and faster for the student to use. Speed and ease of use have become critical needs in the era of compressed anatomical curricula.
The development of this atlas required the combined efforts of a large group of people and the good fortune to have all of these resources available simultaneously. First, we had the complete support of Lippincott Williams & Wilkins (LWW). This support came in many forms, from editorial and production assistance and project funding to art direction and expert market analysis as well as many words of encouragement.
Second, we had the exceptional talents of the creative team at the Anatomical Chart Company (ACC). ACC produces the thousands of anatomical and diagnostic charts that are displayed in clinics and doctors' offices all over the world. The ACC creative team recruited a small army of the best medical illustrators in the country, kept this army organized, and guided them throughout the project. The ACC design team created a truly inspired design and oversaw the construction of pages. Working with the LWW production team, ACC also guided this complex atlas through the production phase.
Third, the authors have been friends and colleagues for many years. The result of our combined efforts to develop educational material has always been greater than the sum of our individual efforts. To this project we have brought the ability and desire to work as a team.
Using these resources to the maximum extent, we have developed an atlas that stands out among contemporary atlases in several areas.

Teaching Perspective
The LWW Atlas of Anatomy is organized regionally. However, the atlas is not simply a series of flat anatomical drawings with every structure labeled. Every aspect of the atlas, from the selection and organization of the plates, to the coloring, style, and labeling of the individual images is grounded in a teaching perspective. The organization follows a teacher's logic, in that it begins with surface anatomy and superficial features, then proceeds into deeper structures with plate groupings that support regional dissection sequences. The labels are carefully selected and placed to tell a story and direct the attention of the viewer to important relationships.

A New Art Style
A new art style was created for the LWW Atlas of Anatomy. The illustrations use a vibrant palette, new surface textures, effective use of shading to add depth, and a clean, uncluttered labeling approach. The main illustrations are designed to depict the most common anatomical features (i.e., ‘average’ anatomy) that a student is likely to encounter in dissections or clinical practice. Common important anatomical variations are also depicted in supporting illustrations.

Careful Selection of Images
There are fewer illustrations in the LWW Atlas of Anatomy than in other atlases. In today's shrinking anatomy curriculum, more is not necessarily better. We carefully considered the number of illustrations necessary to get the job done, with no superfluous figures or concepts. Illustrations are placed in logical dissection order, followed by summary illustrations (systemically organized illustrations of vessels and nerves) that help the student assemble the parts into a whole.

Consistent Perspective
To aid the novice, the images in the LWW Atlas of Anatomy use consistent viewpoints: Directly anterior, directly posterior, directly lateral, or directly medial. The specimen is always placed in the anatomical position. Oblique views and quartering views are not used. Positioning of the limbs or the head in other than the anatomical position has been strictly avoided.

Effective Use of Color
Images in the LWW Atlas of Anatomy use color to draw the viewer's attention to the important part of the figure. Many figures have highly detailed peripheral anatomy rendered in gray to provide context for the illustration without distracting the viewer from the central theme. Summary illustrations use this color technique to particular advantage to show systemic anatomy of body regions.

Ghosted Structures
Many illustrations in the LWW Atlas of Anatomy employ a ghosting technique to allow the viewer to look into the illustration in greater depth. In some illustrations, the viewer looks through ghosted structures to see important anatomical relationships. In other illustrations, a solid object is rendered as a ghost where it passes behind another solid object. By use of these ghosting techniques, we are able to illustrate the relationships of deep structures to more superficial structures and allow students to see connections and associations that previously they had to imagine.
Limited Labeling
We have intentionally limited the number of labels per illustration in the LWW Atlas of Anatomy. We deliberately selected only those structures most likely to be taught in modern curricula and to provide labels for those structures. We did not label everything in each illustration. Many additional structures could have been labeled, but at a loss of the didactic impact of the image.

Effective Label Placement
We have juxtaposed labels to increase the pedagogical impact of the illustration. These label placements encourage the student to notice important relationships. We also have used lists of labels to reinforce the relationship of parts of structures to the whole. The arrangement of labels, combined with the use of color, leaves little doubt as to the intent of the illustration.

No Captions
The LWW Atlas of Anatomy has no captions or text to explain the figures. Market analysis indicates that students and faculty are sharply divided on whether or not this type of material is useful. It is our feeling that an atlas is a supplement to a textbook. We feel that students consult an atlas for visual identification, not description, and that lengthy discussion of the illustrations is not necessary if the illustrations are designed and organized properly and used in the context of text materials.

Complete Product Package
We are also offering with the text a set of supporting products designed to help students learn anatomy. All of the images are available electronically in an interactive atlas that can be accessed on thePoint (Lippincott Williams & Wilkins's website). The interactive atlas has several useful features, including a search function and zoom and compare features. Students can also test their knowledge of anatomy with a unique drag-and-drop labeling exercise available for each image. Instructors also receive an image bank that provides each image in a file suitable for multimedia presentations and an extensive repository of anatomy-oriented test questions
The LWW Atlas of Anatomy has taken many years to complete, and its creation took full advantage of electronic communication and imaging. It has not been an easy feat, as the artists, editors, authors, and publisher are spread all over the country. Approximately 7500 versions of the illustrations were reviewed and critiqued during the course of the project. We all suffered moments of fatigue but the result is well worth the time invested. The experience has been both exhausting and exhilarating.

Product Details

Paperback: 592 pages
Publisher: Lippincott Williams & Wilkins; 1 Blg edition (July 30, 2008)
Language: English
ISBN-10: 0781788668

List Price: $84.95

Hartwig: Fundamental Anatomy

2011-04-11T07:27:00.000-07:00

The anatomy of the human body has been well-documented and thoroughly explicated in print for at least 100 years. Education pioneers, such as J.C.B. Grant, W.H. Hollinshead, and D.J. Cunningham (to name just a few), inspired the teaching of gross anatomy with enlightening but very different emphases and perspectives. The material results were profound, multiedition texts with successive titles like Grant's Method of Anatomy, Hollinshead's Textbook of Anatomy, and Cunningham's Textbook of Anatomy. These books expressed the personal cognitive framework of their creators for understanding how the body is constructed. Grant's approach was strikingly visual and emphasized a region-by-region study of the body. Hollinshead wrote brilliantly of function and reviewed anatomy in a combined systemic and regional approach. Cunningham's text, along with the more familiar Gray's Anatomy, is one of the few purely systemic approaches to the subject.
The era of extensive anatomy courses is over, however, largely because the curricular demands of medical school limit the time that can be devoted to anatomy and compel students to think about clinical applications of structure from the beginning of their training. As a result, the dominant texts of today tend to emphasize the regional approach of Grant, supplemented with clinical correlations and case studies. The days of eponymous book titles are now historical, with such titles being replaced by Clinically Oriented Anatomy or Clinical Anatomy, which also have matured through numerous revisions to become comprehensive references of gross anatomy.
Students need 'perspective' books in addition to comprehensive reference books. People acquire subject knowledge through two basic pathways, which sometimes are described as 'bottom-up' and 'top-down.' The bottom-up pathway is the method of assembling facts and mastering their relationships to arrive at some understanding of the subject in general. The top-down pathway, naturally, is the reverse a method of learning the organization of a subject before exercising its factual basis. In theory, these pathways enable the student to both understand and command a subject. A concise dose of the top-down approach can greatly improve the effectiveness of the bottom-up approach. That is the essential purpose of this book.
The present text expands two aspects of anatomic education that blend well together: embryology, and systemic anatomy. In many medical schools, embryology is taught either as a low-unit course to supplement anatomy or as a few lectures within the anatomy course.
The other design emphasis of this book is an expansion of systemic information. Many degree programs in the health professions now teach the body 'system-by-system,' which is an effective way of integrating the normal structure and function of a tissue complex with disease processes and medical management. Body systems are unified by function. The sequence of systems as presented in this book tries to balance the logic of body design with a minimum redundancy of coverage. A body-wide system, circulation, leads off as a guide to all body regions. The other organ systems follow, given their tightly related embryologies, functions, and relatively simple (anatomically, at least) innervation schemes. There is no separate chapter on the endocrine organs; rather, they are discussed in the appropriate embryologic passages. The peripheral nervous system and the musculoskeletal system are interrelated both spatially and functionally. Although the nature of how they function is similar from one region to the next, the number of named nerves, muscles, bones, and joints is quite large, so these chapters are relatively long. To maintain the pace of embryologic discourse, they are placed after the organ chapters.
Lastly, a brief chapter on skin and superficial fascia concludes the book. This is an awkward topic for a systemic book of gross anatomy, because a structure of great clinical relevance, the mammary gland, grows within a body-wide system of integument that otherwise is more microscopic (histologic) than macroscopic. The breast must be covered in an anatomy book, but as a modified sweat gland it is appropriately placed in a chapter, albeit confined, on the integument.

Product Details

Paperback: 304 pages
Publisher: Lippincott Williams & Wilkins; 1 edition (February 23, 2007)
Language: English
ISBN-10: 0781768888
ISBN-13: 978-0781768887
Product Dimensions: 9.9 x 6.8 x 0.8 inches

List Price: $51.50

Berne Levy Physiology 6th Updated Edition: with Student Consult online access

2011-03-30T08:26:00.000-07:00

Berne and Levy Physiology has long been respected for its scientifically rigorous approach and now includes major updates to bring you all of the latest knowledge in the field. Bruce M. Koeppen and Bruce A. Stanton present a honed and shortened edition that emphasizes the core information needed by students of physiology today and features a full-color design and artwork to enhance readability and enrich your comprehension of every concept. With access to the full contents online at Student Consult, this time-honored book delivers an in-depth understanding of physiology more powerfully and effectively than ever before.

Book Features

Describes all of the mechanisms that control and regulate bodily function using a clear and intuitive organ system-based approach.
Provides a rich understanding of the body's dynamic processes through key experimental observations and examples.
Includes Student Consult access to the complete and searchable contents of the book online, as well as relevant bonus content from other Student Consult titles, an image gallery, 10 physiology animations, and much more.

New in this edition

Features updated coverage throughout to expand your understanding of the most current trends in physiology and medicine, including the latest cellular and molecular knowledge.
Includes shaded boxes that highlight and explain important clinical and molecular information.
Presents new section editors who ensure that you are getting the freshest, most clinically relevant information available today.
Summarizes need-to-know information in each chapter with Key Points sections.

Contents
Section I: Cellular Physiology 1

1. Principles of Cell Function 3
2. Homeostasis of Body Fluids 20
3. Signal Transduction, Membrane Receptors, Second Messengers, and Regulation of Gene Expression 34
Section II: The Nervous System 51

4. The Nervous System: Introduction to Cells and Systems 53
5. Generation and Conduction of Action Potentials 65
6. Synaptic Transmission 82
7. The Somatosensory System 105
8. The Special Senses 123
9. Organization of Motor Function 157
10. Higher Functions of the Nervous System 201
11. The Autonomic Nervous System and its Central Control 218
Section III: Muscle 231

12. Skeletal Muscle Physiology 233
13. Cardiac Muscle 256
14. Smooth Muscle 268
Section IV: The Cardiovascular System 287

15. Overview of Circulation 289
16. Elements of Cardiac Function 292
17. Properties of the Vasculature 330
18. Regulation of the Heart and Vasculature 370
19. Integrated Control of the Cardiovascular System 393
Section V: The Respiratory System 415

20. Structure and Function of the Respiratory System 417
21. Mechanical Properties of the Lung and Chest Wall: Static and Dynamic 430
22. Ventilation (V), Perfusion (Q), and V/Q Relationships 444
23. Oxygen and Carbon Dioxide Transport 459
24. Control of Respiration 468
25. Nonrespiratory Functions of the Lung 477
Section VI: Gastrointestinal Physiology 485

26. Functional Anatomy and General Principles of Regulation in the Gastrointestinal Tract 487
27. The Cephalic, Oral, and Esophageal Phases of the Integrated Response to a Meal 496
28. The Gastric Phase of the Integrated Response to a Meal 504
29. The Small Intestinal Phase of the Integrated Response to a Meal 516
30. The Colonic Phase of the Integrated Response to a Meal 533
31. Transport and Metabolic Functions of the Liver 542
Section VII: The Renal System 555

32. Elements of Renal Function 557
33. Solute and Water Transport along the Nephron: Tubular Function 578
34. Control of Body Fluid Osmolality and Volume 594
35. Potassium, Calcium, and Phosphate Homeostasis 619
36. Role of the Kidneys in the Regulation of Acid-Base Balance 636
Section VIII: The Endocrine and Reproductive Systems 651

37. Introduction to the Endocrine System 653
38. Hormonal Regulation of Energy Metabolism 664
39. Hormonal Regulation of Calcium and Phosphate Metabolism 696
40. The Hypothalamus and Pituitary Gland 706
41. The Thyroid Gland 725
42. The Adrenal Glands 738
43. The Male and Female Reproductive Systems 758
Index 799

Product Details

Hardcover: 848 pages
Publisher: Mosby; 6 edition (December 11, 2009)
Language: English
ISBN-10: 032307362X
ISBN-13: 978-0323073622
Product Dimensions: 10.9 x 8.8 x 1.4 inches
Author: Bruce M. Koeppen MD PhD and Bruce A. Stanton PhD

List Price: $110.00

Gray's Anatomy for Students 2nd Edition: With STUDENT CONSULT Online Access

2011-03-29T08:43:00.000-07:00

It didn't take long for students around the world to realize that anatomy texts just don't get any better than Gray's Anatomy for Students. Only in its 2nd edition, this already popular, clinically focused reference has moved far ahead of the competition and is highly recommended by anyone who uses it. A team of authors with a wealth of diverse teaching and clinical experience has updated and revised this new edition to efficiently cover what you're learning in contemporary anatomy classes.
An improved format, updated clinical material, and remarkable artwork by renowned illustrators Richard Tibbitts and Paul Richardson make anatomy easier than ever for you to master. Unique coverage of surface anatomy, correlative diagnostic images, and clinical case studies demonstrate practical applications of anatomical concepts. And, an international advisory board, comprised of more than 100 instructors, ensures that the material is accurate, up to date, and easy to use. To further enhance your learning experience, you'll have access to the entire book online, with additional content, interactive exercises, and more.

Book Features

Offers the complete contents of the book online as well as additional material, interactive exercises, and much more, at www.studentconsult.com, giving you anywhere, anytime access to the information you need.
Uses more than 1,000 innovative original illustrations- by renowned illustrators Richard Tibbitts and Paul Richardson-to capture anatomical features with unrivalled clarity, and makes body structures easy to locate and remember from one illustration to another through consistent use of color.
Includes over 300 clinical photographs, including radiological images depicting surface anatomy and common clinical applications of anatomic knowledge.
Presents an organization by body region that parallels the approach used in most of today's anatomy courses.
Features conceptual overviews summarizing each body region's component parts, functions, and relationship to other bodily organs.
Uses clinical cases to underscore the real-life relevance of the material.
Promotes further learning with other fine ancillaries from Gray's, including Gray's Atlas of Anatomy, Dorland's/Gray's Pocket Atlas of Anatomy, Gray's Dissection Guide for Human Anatomy, and Gray's Anatomy for Students Flash Cards.

New in this edition

Features a rewritten abdomen section for greater clarity.
Provides updates and revisions to clinical material to provide you with the absolute latest knowledge in the field.
Includes expanded discussions of cranial nerves for added clinical relevancy.
Uses a new internal design and presents an improved index for easier retrieval of information.
Provides more information on the general aspects of anatomy via introduction chapter.

Product Details

Paperback: 1136 pages
Publisher: Churchill Livingstone; 2 edition (February 11, 2009)
Language: English
ISBN-10: 0443069522
ISBN-13: 978-0443069529
Product Dimensions: 10.9 x 8.5 x 1.6 inches
Author: Richard L. Drake, A. Wayne Vogl, Adam W. M. Mitchell

List Price: $83.95

Fry: Essential Biochemistry for Medicine

2011-03-28T07:59:00.000-07:00

To the uninitiated, biochemistry is a complex and intricate subject, but importantly it is a subject that underpins the biosciences, including medicine. The book is simply presented but packed with information, and it contains a full index to aid quick navigation.
Essential Biochemistry for Medicine provide a useful and helpful supplement to lectures and workshops, a biochemical–physiological–medical continuum, full of numerous medical examples, additional factual material and FOCUS sections on some favourite medical topics.
This text addresses the growing need for a new kind of textbook for medical and biomedical undergraduates that presents a fully integrated approach to biochemistry and medicine, rather than covering biochemistry on a topic by topic basis with a smattering of 'medical cases' to demonstrate relevance. The majority of pre-clinical medical students do not need a detailed biochemistry text book, but rather "biochemistry as a basis" or as an "add-on". The major challenge for them is to integrate biochemical knowledge, to clinical application in the understanding of the etiology of diseases, their diagnosis and treatment.
Essential Biochemistry for Medicine is not intended to be an exhaustive, comprehensive reference; rather a concise, accessible guide that will help first year students, from a wide spectrum of backgrounds, gain a good basic understanding of the biochemistry behind common medical disorders. It integrates biochemistry with clinical applications and the understanding of the etiology of diseases, their diagnosis and treatment. Each chapter includes a concise and simple introduction to the relevant biochemistry and terminology to reinforce what biomedical students have covered, orientate them and encourage them to consider the medical context; whilst at the same time outlining the biochemistry in a simple, "must know" format, for medical students before directing them to the all important clinical considerations.

Book Features

A fully integrated approach to give students a basic understanding of the biochemistry behind common medical disorders.
Concise, accessible and well-written with numerous clear illustrations in full colour throughout.
Uses 'FOCUS' sections to expand on certain areas such as diabetes, HIV and obesity.
Includes links and quick references for those wanting a broader knowledge of each topic.

Contents
1 Nutritional requirements 1
1.1 Carbohydrates and sugars 1
1.2 Glycogen 2
1.3 Glycaemic index 3
1.4 Lipids 3
1.5 Proteins and amino acids 6
1.6 Biological value 7
1.7 Other energy sources 7
1.8 Vitamins 8
1.9 Minerals 11
2 Metabolism and energy 13
2.1 A metabolic strategy 13
2.2 Carbohydrate metabolism (catabolic) 14
2.3 Glycolysis 15
2.4 Tricarboxylic acid cycle (TCA cycle – Krebs cycle – citric acid cycle) 17
2.5 Oxidative phosphorylation 17
2.6 Brown adipose tissue and heat generation 17
2.7 Glycogenolysis 18
2.8 Carbohydrate metabolism (anabolic) 20
2.9 Gluconeogenesis 20
2.10 Glycogenesis 20
2.11 Fatty acid catabolism 22
2.12 Amino acid catabolism 23
2.13 Blood glucose homeostasis 24
2.14 Glucokinase and hexokinase 27
2.15 Glucose transporters 27
2.16 Diabetes mellitus 28
2.17 Type 1 diabetes 29
2.18 Type 2 diabetes 30
2.19 Insulin/Glucagon effects on metabolism 32
2.20 Hyperglycaemia and associated pathology 33
2.21 Glycation 33
2.22 The polyol pathway 35
3 Regulating body weight 37
3.1 Obesity 37
3.2 Weight regulation 37
3.3 Controlling food intake 38
3.4 Pre-gastric factors 38
3.5 Gastrointestinal and post-absorptive factors 39
3.6 Enteric nervous system 39
3.7 The central nervous system 40
3.8 Long-term control 41
3.9 CNS factors 41
3.10 Lifestyle changes 42
3.11 The basics of dieting 44
3.12 Medical and surgical treatment 45
4 Digestion and absorption 47
4.1 The gastrointestinal tract 47
4.2 Gastric acid production 48
4.3 Proton pump inhibitors 50
4.4 Helicobacter pylori 51
4.5 The small intestine 52
4.6 The gastrointestinal barrier 52
4.7 Paneth cells 53
4.8 The enteric endocrine system 54
4.9 The pancreas 55
4.10 Absorption in the small intestine: general principles 55
4.11 Crossing the gastrointestinal barrier 57
4.12 Absorption and secretion of water and electrolytes 58
4.13 Pathophysiology of diarrhoea 59
4.14 Rehydration therapy 60
4.15 Absorption of sugars and amino acids 60
4.16 Absorption of amino acids and peptides 62
4.17 Absorption of lipids 63
4.18 Absorption of minerals and metals 63
4.19 Malabsorption syndromes 65
4.20 Steatorrhoea 70
4.21 Lactose intolerance 70
4.22 Glucose–galactose malabsorption 70
4.23 Coeliac disease 71
4.24 Crohn’s disease 71
4.25 The large intestine 71
5 Synthesis, mobilisation and transport of lipids and lipoproteins 75
5.1 Fatty acid synthesis 75
5.2 Long-term control of fatty acid synthase 77
5.3 Triacylglycerols 77
5.4 Mobilisation of lipid stores 78
5.5 Transport of lipids 78
5.6 Intestinal uptake of lipids 78
5.7 Chylomicrons 79
5.8 Apolipoproteins 79
5.9 Export of fat from the liver 82
5.10 Role of HDL in lipid metabolism 82
5.11 Apoprotein classes 84
5.12 LDL receptors 84
5.13 Disorders of lipoprotein metabolism 85
5.14 Alzheimer’s disease 85
5.15 Pharmacologic intervention 85
6 The liver 91
6.1 General overview 91
6.2 Storage diseases 91
6.3 Glycogen storage diseases 92
6.4 General liver metabolism 92
6.5 Production and excretion of bile 93
6.6 Pattern and control of bile secretion 96
6.7 Clinical significance of bile secretion 97
6.8 Cholesterol metabolism 97
6.9 Regulating cholesterol synthesis 97
6.10 Regulating sterol synthesis 98
6.11 Drug metabolism 99
6.12 Breakdown of haem (Haemoglobin) 102
6.13 Bilirubin 102
6.14 Jaundice 104
6.15 Protein metabolism – albumin 104
6.16 Protein metabolism – nitrogen metabolism and the urea cycle 105
6.17 The urea cycle 109
6.18 Regulation of the urea cycle 109
6.19 Urea cycle defects 111
6.20 Neurotoxicity associated with ammonia 111
7 Alcohol metabolism and cirrhosis 113
7.1 The alcohol dehydrogenase system 113
7.2 The microsomal cytochrome P450 system 115
7.3 The peroxisome catalase system 115
7.4 The consequence of alcohol intake 115
7.5 Short-term metabolic consequences of alcohol intake 116
7.6 Long-term consequences of chronic alcohol intake 116
7.7 Cirrhosis of the liver 118
7.8 Complications of cirrhosis 118
8 Protein structures 121
8.1 Protein primary structure 121
8.2 Peptide bonds 121
8.3 Protein interactions 121
8.4 Levels of protein structure 123
8.5 Types of protein structure 123
8.6 The α-helix 124
8.7 The β-sheet 124
8.8 Protein folding 124
8.9 Carbohydrates and lipid association with protein 125
8.10 Disruption of the native state 126
8.11 Incorrect protein folding and neurodegenerative disease 126
8.12 The study of proteins 126
8.13 Defects in protein structure and function 127
8.14 Glycolipid degradation 128
8.15 Protein receptor defects 129
8.16 Transformation and carcinogenesis 129
9 Enzymes and diagnosis 131
9.1 Enzyme nomenclature 131
9.2 Catalytic mechanism 132
9.3 Lowering the activation energy 132
9.4 Reactions, rates and equilibria 133
9.5 Michaelis–menten kinetics 134
9.6 Lineweaver–burk 134
9.7 Isoenzymes 135
9.8 Enzyme inhibitors 136
9.9 The control of enzyme activity 137
9.10 Allosteric enzymes 138
9.11 Covalent modification of enzymes 138
9.12 Control proteins 139
9.13 Enzymes in medicine 140
9.14 Biomarkers and enzymes in diagnosis 142
9.15 Enzymes in the diagnosis of pathology 143
9.16 Liver-function tests 144
10 The kidney 147
10.1 Nephron structure 147
10.2 Kidney function 147
10.3 Diuretics 150
10.4 Anti-diuretic hormone 151
10.5 Aquaporins 151
11 Haemostasis 153
11.1 Blood vessel trauma 153
11.2 Blood coagulation 154
11.3 The coagulation cascade 154
11.4 The tissue factor (TF) pathway 154
11.5 The contact activation pathway 155
11.6 The common pathway 156
11.7 Amplification of the clotting process 156
11.8 Co-factors in coagulation 156
11.9 Regulators of coagulation 157
11.10 Breaking down the clot 158
11.11 Disorders of haemostasis 159
11.11.1 Platelet disorders 159
11.11.2 Disorders of coagulation 159
11.12 Pharmacology of haemostasis 160
12 Bone metabolism and calcium homeostasis 167
12.1 Mineral density test 167
12.2 Osteoblasts 167
12.3 Osteoclasts 168
12.4 Bone structure 168
12.5 Composition of bone 169
12.6 Collagen 169
12.7 Bone disorders 170
12.8 Contributing factors to bone disorders 171
12.9 Treatments of bone disorders 172
12.10 Calcium homeostasis 172
12.11 Endocrine regulation of [Ca2+]ECF 172
12.12 Parathyroid hormone 173
12.13 Vitamin D 174
13 Intracellular signalling 175
13.1 Hormones 175
13.2 The hierarchical nature of hormonal control 176
13.3 Hormone synthesis and secretion 178
13.4 Hormonal control 179
13.5 Types of chemical messenger 181
13.6 Intracellular signalling and signal transduction 182
13.7 Cell-surface and intracellular receptors 182
13.7.1 Cell-surface receptors 182
13.7.2 Intracellular receptors 185
13.8 Second messengers 187
13.9 The glucagon receptor 190
13.10 The gastrin receptor 190
14 Inflammation 193
14.1 The acute inflammatory response 193
14.2 Leukocyte transmigration 194
14.3 Chronic inflammation 196
14.4 Mediators of inflammation 197
14.5 Acute-phase proteins 197
14.6 Patterns of acute and chronic inflammation 199
14.7 Inflammatory disorders 199
15 The immune response 209
15.1 Leukocytes 209
15.2 Innate immunity 209
15.2.1 The complement system 210
15.2.2 Complement deficiency 211
15.2.3 Natural killer cells 213
15.3 Passive immunity 213
15.4 Acquired immunity 213
15.4.1 The humoral immune response 213
15.4.2 The clonality of B-cells 214
15.4.3 Antibodies 214
15.4.4 The Cell-mediated immune response 216
15.4.5 Antigen-presenting cells 219
15.4.6 Interaction of APCs with T-cells 219
15.4.7 Major histocompatibility complex (MHC) 219
15.4.8 Autoimmunity 221
15.4.9 Tolerance 222
15.4.10 Overcoming tolerance 223
15.4.11 Treating autoimmune disease 224
16 Mitochondrial dysfunction 231
16.1 Mitochondrial DNA 231
16.2 Non-Mendelian inheritance 231
16.3 Mitochondrial cytopathies 232
16.4 Common symptoms of mitochondrial dysfunction 234
16.5 Mitochondria and ageing 234
16.6 Diagnosis of mitochondrial myopathies 235
17 Nerve and muscle systems 237
17.1 Nerves 237
17.2 The nerve message 237
17.3 Diseases of the nervous system 240
17.4 Specific neural disorders 241
17.5 Muscle types 246
17.6 The neuromuscular junction 247
17.7 Neuromuscular disease 248
17.8 Sarcomeres and focal adhesions 249
17.9 Dystrophin 250
17.10 Intrinsic cardiomyopathy 251
17.11 Metabolic diseases of muscle 252
18 The cytoskeleton 255
18.1 Actin filaments/microfilaments 255
18.2 Intermediate filaments 255
18.3 Microtubules 256
18.4 Spectrin 256
18.5 Alzheimer’s disease 257
18.6 Amyotrophic lateral sclerosis 258
18.7 Synapsins 258
19 Genes and medicine 259
19.1 Chromosomes 259
19.2 Chromosome banding 259
19.3 Karyotypes 260
19.4 The spectral karyotype: fluorescence in situ hybridisation (FISH) 260
19.5 Gene mutations 262
19.6 Genetic disorders 262
19.7 Gene testing 263
19.7.1 Advantages and disadvantages of gene testing 264
19.8 The human genome project 264
19.8.1 How do we compare to other organisms? 265
19.9 Gene therapy 265
19.9.1 Current status 266
19.9.2 Some ethical questions 267
19.10 The next step: functional genomics 267
19.11 Pharmacogenomics 268
19.12 Genetic engineering: recombinant DNA technology 270
19.12.1 The tools and terminology of the genetic engineer 270
19.12.2 Transferring genes 271
19.12.3 Genetic markers 272
19.13 The polymerase chain reaction (PCR) 272
19.14 Complementary DNA (cDNA) 273
19.15 DNA probes 273
19.16 DNA sequencing 274
19.17 Genetic engineering applications 276
19.18 Commercial gene products 276
19.19 Gene therapy 278
19.20 Controlling gene expression 278
19.21 Transcription factors 280
19.22 Response element 281
19.23 Genes and cancer: the cell cycle 281
19.23.1 Checkpoints and cell-cycle regulation 282
19.23.2 Initiation of cell division and differentiation 283
19.23.3 Genes controlling the cell cycle 283
19.24 Viruses and cancer 284
19.25 Apoptosis 285
19.26 Caspases 285
20 Antibacterial drug resistance 291
20.1 Horizontal gene transfer 291
20.2 Penicillin resistance 292
20.3 Sulphonamide resistance 294
20.4 Bacterial efflux pumps 296
20.5 Pseudomonas aeruginosa 297
20.6 Vancomycin 297
20.7 Staphylococcus aureus 298
20.8 Clostridium difficile 298
Index 299

Product Details

Hardcover: 326 pages
Publisher: Wiley; 1 edition (November 30, 2010)
Language: English
ISBN-10: 047074328X
ISBN-13: 978-0470743287
Product Dimensions: 9.8 x 6.8 x 0.9 inches
Author: Mitchell Fry

List Price: $109.95

Lymph Node Cytopathology (Essentials in Cytopathology Series)

2011-03-27T07:34:00.000-07:00

The subspeciality of cytopathology is 60 years old and has become established as a solid and reliable discipline in medicine. As expected, cytopathology literature has expanded in a remarkably short period of time, from a few textbooks prior to the 1980s to a current and substantial library of texts and journals devoted exclusively to cytomorphology. Essentials in Cytopathology does not presume to replace any of the distinguished textbooks in cytopathology. Instead, the series will publish generously illustrated and user-friendly guides for both pathologists and clinicians.
Building on the amazing success of The Bethesda System for Reporting Cervical Cytology, now in its second edition, the Series will utilize a similar format, including minimal text, tabular criteria, and superb illustrations based on real-life specimens. Essentials in
Cytopathology will, at times, deviate from the classic organization of pathology texts. The logic of decision trees, elimination of unlikely choices, and narrowing of differential diagnosis via a pragmatic approach based on morphologic criteria will be some of the strategies used to illustrate principles and practice in cytopathology.
Most of the authors for Essentials in Cytopathology are faculty members in The Johns Hopkins University School of Medicine, Department of Pathology, Division of Cytopathology. They bring to each volume the legacy of John K. Frost and the collective experience of a preeminent cytopathology service. The archives at Hopkins are meticulously catalogued and form the framework for text and illustrations. Authors from other institutions have been selected on the basis of their national reputations, experience, and enthusiasm for cytopathology. They bring to the series complementary viewpoints and enlarge the scope of materials contained in the photographs.
You will find this series useful and welcome your feedback as you place these handbooks by your microscopes and into your book bags.

Contents
1 Introduction
2 Overview of Ancillary Methods in Lymph Node FNA diagnosis
3 Lymphadenopathy: Anatomic and Clinical Clues to Fine Needle Aspiration Diagnosis
4 Cytology of Normal/Reactive Lymph Nodes
5 Overall Assessment of the Aspirate: Diagnostic Clues
6 Overview of the Algorithmic Pattern-Based Approach to Lymph Node FNA
7 The Polymorphous Lymphoid Cell Pattern
8 The Monotonous Small-Cell Pattern
9 The Monotonous Intermediate-Sized Cell Pattern
10 The Monotonous Large Cell Pattern
11 The Pleomorphic Cell Pattern
12 Infectious and Noninfectious Lymphadenitis
13 Unusual Neoplastic and Nonneoplastic Conditions of Lymph Nodes
14 Pitfalls and Limitations of FNA of Lymph Nodes
Index

Product Details

Paperback: 287 pages
Publisher: Springer; 1st edition (September 30, 2010)
Language: English
ISBN-10: 1441969632
ISBN-13: 978-1441969637
Product Dimensions: 8.2 x 5 x 0.5 inches3
Author: Stefan E. Pambuccian and Ricardo H. Bardales

List Price: $79.95

Lennette's Laboratory Diagnosis of Viral Infections 4th Edition (Infectious Disease and Therapy)

2011-03-26T07:48:00.000-07:00

Clinical virology has changed at an astounding pace in the 10 years since publication of the previous edition, and this edition has been completely rewritten to reflect this new reality.
As in previous editions, the work is divided into two parts. Part one is similar in scope to that of the previous editions and provides a detailed description of the various techniques forming the foundation of modern diagnostic virology. Part two, on the other hand, presented a greater challenge. A simple listing of virus families and their various clinical manifestations was clearly the easiest option, but this approach has already been well traveled. Instead, there is a syndromic approach. Thus, if presented with a patient having symptoms of viral encephalitis, for example, you can now refer to the chapter on CNS infections, where they will find a differential diagnosis of potential causative agents, along with suggestions for the appropriate diagnostic approach.
Molecular techniques continue to grow in importance and are covered in depth by new chapters on a variety of topics, including the design of molecular tests, the importance of genotyping and viral sequence analysis, and the use of microarrays in diagnostic virology. Another emerging theme is the increased awareness of global health issues, reflected here by a new chapter regarding viral testing in resource-limited settings. Finally, new associations continue to be made between clinical disease and viruses, and these are discussed in the chapters on respiratory infections, polyomavirus infections, hemorrhagic fevers, and elsewhere throughout the book.
Readers of this new edition will find the book useful and will gain a little of author's enthusiasm for this ever changing and endlessly fascinating field.

Contents
1. Verification and Validation of Virological Laboratory Tests in the Routine Diagnostic Laboratory
2. Statistical Evaluation of Diagnostic Tests
3. Molecular Amplification Methods in Diagnostic Virology
4. Viral Genotyping and the Sequencing Revolution
5. Design of Molecular Virologic Tests
6. Microarray Detection of Viruses
7. Virus Isolation
8. Diagnosis by Viral Antigen Detection
9. Serologic Tests in Clinical Virology
10. Surgical Pathology and Diagnostic Cytology of Viral Infections
11. Electron Microscopy of Viral Infections
12. Laboratory Diagnosis of Viruses in Resource-Limited Settings
13. Antiviral Therapy
14. Common Viral Infections of Childhood
15. Respiratory Virus Infections
16. Gastrointestinal Tract Infections
17. Infections of the Skin and Mucosa
18. Cardiovascular Viral Infections
19. Viral Hepatitis
20. Viral Hemorrhagic Fevers
21. Infections of the Central Nervous System
22. Sexually Transmitted Infections
23. Human Immunodeficiency Viruses: HIV-1 and HIV-2
24. Diagnosis of Polyomavirus Infection, Replication, and Disease
25. Ocular Viral Infections
26. Arthropod-Borne Viruses
27. Viral Infections of the Immunocompromised Host
Index

Product Details

Hardcover: 510 pages
Publisher: Informa Healthcare; 4 edition (March 26, 2010)
Language: English
ISBN-10: 142008495X
ISBN-13: 978-1420084955
Product Dimensions: 10.1 x 7.1 x 1.5 inches
Editor: Keith R. Jerome

List Price: $324.00

WHO classification of lymphoid neoplasms (2008), including only neoplasms potentially encountered in fine needle aspiration of lymph nodes and mediastinum

2011-03-25T07:33:00.000-07:00

Precursor lymphoid neoplasms

B lymphoblastic leukemia/lymphoma NOS
T lymphoblastic leukemia/lymphoma
Mature B-cell neoplasms

Chronic lymphocytic leukemia/small lymphocytic lymphoma
Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia
Plasma cell myeloma
Extraosseous plasmacytoma
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type
Nodal marginal zone lymphoma
Follicular lymphoma
Mantle cell lymphoma
Diffuse large B-cell lymphoma, NOS

T-cell/histiocyte-rich type
Diffuse large B-cell lymphoma with chronic inflammation
Primary mediastinal large B-cell lymphoma
Intravascular large B-cell lymphoma
ALK+ large B-cell lymphoma
Plasmablastic lymphoma
Large B-cell lymphoma associated with HHV8+ Castleman disease

Primary effusion lymphoma
Burkitt lymphoma
B-cell lymphoma, unclassifiable, Burkitt-like
B-cell lymphoma, unclassifiable, Hodgkin lymphoma-like

Mature T-cell and NK-cell neoplasms
Adult T-cell lymphoma/leukemia
Extranodal T-cell/NK-cell lymphoma, nasal type
Mycosis fungoides
Peripheral T-cell lymphoma, NOS
Angioimmunoblastic T-cell lymphoma
Anaplastic large cell lymphoma, ALK+ type
Anaplastic large cell lymphoma, ALK− type
Hodgkin lymphoma
Nodular lymphocyte-predominant Hodgkin lymphoma
Classic Hodgkin lymphoma

Nodular sclerosis Hodgkin lymphoma
Lymphocyte-rich classic Hodgkin lymphoma
Mixed cellularity Hodgkin lymphoma
Lymphocyte depletion Hodgkin lymphoma

Posttransplant lymphoproliferative disorders (PTLD)
Plasmacytic hyperplasia
Infectious mononucleosis-like PTLD
Polymorphic PTLD
Monomorphic PTLD (B & T/NK cell types)
Classic HD-type PTLD
Histiocytic and dendritic cell neoplasms
Histiocytic sarcoma
Langerhans cell histiocytosis
Langerhans cell sarcoma
Interdigitating dendritic cell sarcoma
Follicular dendritic cell sarcoma
Fibroblastic reticular cell tumor
Indeterminate dendritic cell sarcoma
Disseminated juvenile xanthogranuloma

Principles of Medical Biochemistry: With STUDENT CONSULT Online Access

2011-03-18T08:06:00.000-07:00

Principles of Medical Biochemistry condenses the information you need into a comprehensive, focused, clinically-oriented textbook. Drs. Gerhard Meisenberg and William H. Simmons covers the latest developments in the field, including genome research, the molecular basis of genetic diseases, techniques of DNA sequencing and molecular diagnosis, and more. An updated and expanded collection of figures and access to the fully searchable text, USMLE test questions, clinical case studies, more online at www.studentconsult.com make this the ideal resource for understanding all aspects of biochemistry needed in medicine.

Book Features

Access the fully searchable text online at www.studentconsult.com, along with downloadable illustrations, 150 USMLE-style test questions, 20 clinical case studies, chapter summaries, and integration links to related subjects.
Understand biochemistry, cell biology, and genetics together in context through an integrated approach.
Get only the information you need for your course with comprehensive yet focused coverage of relevant topics.
Review and reinforce your learning using the glossary of technical terms, highlighted in the text and with interactive features online.

New in this edition

Tap into the most up-to-date coverage of new developments in genome research, the molecular basis of genetic diseases, techniques of DNA sequencing and molecular diagnosis, RNA interference as a mechanism both for regulation of gene expression and for anti-viral defense, and more.
Gain a clear visual understanding through new and updated figures that provide current and relevant guidance.
Make the link between basic science and clinical medicine with new Clinical Example boxes in nearly every chapter.

Focus on the most essential biochemistry principles and how they apply to clinical medicine.

Contents

Introduction to biomolecules
Introduction to protein structure
Oxygen transporters : hemoglobin and myoglobin
Enzymatic reactions
Coenzymes
DNA, RNA, and protein synthesis
Viruses
The human genome
Protein targeting
Introduction to genetic diseases
DNA technology
Biological membranes
The cytoskeleton
The extracellular matrix
Plasma proteins
Extracellular messengers
Intracellular messengers
Cellular growth control and cancer
Digestive enzymes
Introduction to metabolic pathways
Glycolysis, tricarboxylic acid cycle, and oxidative phosphorylation
Carbohydrate metabolism
The metabolism of fatty acids and triglycerides
The metabolism of membrane lipids
Lipid transport
Amino acid metabolism
Heme metabolism
The metabolism and purines and pyrimidines
Vitamins and minerals
Integration of metabolism

Product Details

Paperback: 640 pages
Publisher: Saunders; 3 edition (May 2, 2011)
Language: English
ISBN-10: 0323071554
ISBN-13: 978-0323071550
Author: Gerhard Meisenberg, William H. Simmons
List Price: $69.95

Burke: Practical Cardiovascular Pathology

2011-03-17T09:16:00.000-07:00

Featuring over 1,000 full-color illustrations, Practical Cardiovascular Pathology is a comprehensive reference guide to cardiac autopsy and surgical pathology of cardiovascular disease. The broad scope includes approaches to autopsy, devices, and molecular autopsy, as well as surgical cardiovascular disease, including biopsies, transplant, vasculitis, excised valves, and heart tumors. The book is geared to pathology residents and practicing surgical pathologists and focuses on illustrated practical diagnosis, including differential diagnosis.
Each chapter includes eight to ten gross and microscopic photographs with legends highlighting the pathologic features of the disease, as well as succinct text covering etiology, clinical aspects, and differential diagnosis. Key information is presented in tabular format wherever possible.
A companion website will offer the fully searchable text and an image bank.

Contents Section 1 Techniques and approach to cardiovascular pathology
1. Examination of the heart
2. Congenital heart disease
3. Handling of surgical specimens .
4. Iatrogenic cardiovascular pathology .
5. Sudden cardiac death, conduction system study and molecular autopsy
Section 2 Ischemic heart disease and diseases of coronary arteries
6. Pathology of coronary atherosclerosis
7. Myocardial infarction
8. Chronic ischemic heart disease
9. Coronary stents
10. Coronary artery bypass grafts
11. Nonatherosclerotic coronary artery disease
Section 3 Cardiomyopathies and endocardial diseases
12. Pathology of cardiomyopathy: an overview
13.Dilated cardiomyopathy
14. Hypertrophic cardiomyopathy
15. Arrhythmogenic cardiomyopathy (arrhythmogenic right ventricular dysplasia/cardiomyopathy)
16. Ventricular noncompaction
17. Restrictive cardiomyopathy and cardiac amyloidosis
18. Cardiac disease in systemic disorders
19. Conditions involving the right ventricle, atria, and interatrial septum
20. Endocardial disease
Section 4 Myocarditis and pericarditis
21. Myocarditis: Classification and etiology
22. Lymphocytic and autoimmune myocarditis
23. Hypersensitivity and toxic myocarditis
24. Giant cell myocarditis and cardiac sarcoidosis
25. Infections of the myocardium
26. Pericardial disease
Section 5 Transplant pathology
27. Cellular rejection
28. Antibody-mediated cardiac allograft rejection
29. Cardiac allograft vasculopathy
Section 6 Disease of heart valves
30. Congenital conditions of the aortic valve
31. Acquired aortic valve disease
32. Mitral valve prolapse and congenital mitral valve disease
33. Acquired mitral valve disease
34. Pulmonary and tricuspid valves
35. Endocarditis
36. Prosthetic heart valves
Section 7 Heart tumors
37. Pediatric heart tumors
38. Cardiac myxoma
39. Miscellaneous benign cardiac tumors and tumor-like lesions in the adult
40. Sarcomas of the heart and great vessels
41. Cardiac lymphoma and metastatic tumors to the heart
Section 8 Vasculitis
42. Aortitis
43. Giant cell arteritis and temporal artery biopsy
44. Polyarteritis nodosa
45. Wegener granulomatosis and Churg-Strauss angiitis
46. Small vessel vasculitis
47. Localized and miscellaneous vasculitis
Section 9 Non-inflammatory diseases of blood vessels
48. Pathology of atherosclerosis involving noncoronary arteries
49. Noninflammatory thoracic aortic aneurysms
Section 10 Thrombotic disorders
50. Arterial aneurysms, excluding aorta
51. Miscellaneous disorders of peripheral vessels
52. Pulmonary embolism and pulmonary hypertension
53. Thrombosis of noncoronary vessels
Index

Product Details

Hardcover: 608 pages
Publisher: Lippincott Williams & Wilkins; Har/Psc edition (November 8, 2010)
Language: English
ISBN-10: 1605478415
ISBN-13: 978-1605478418
Product Dimensions: 11.1 x 8.5 x 1.1 inches
Editor: Allen P. Burke, Fabio Tavora
List Price: $229.00

Essential Clinical Anatomy 4th Edition

2011-03-16T08:01:00.000-07:00

Essential Clinical Anatomy, Fourth Edition presents the core anatomical concepts found in Clinically Oriented Anatomy, Sixth Edition in a concise, easy-to-read, and student-friendly format. This streamlined book that includes clinical Blue Boxes, surface anatomy, and medical imaging is an excellent review for the larger text and an ideal primary text for shorter medical courses and/or health professions courses with brief coverage of anatomy.
The Fourth Edition features a modified layout with new and improved artwork. The clinical Blue Boxes are now grouped to reduce interruption of text and are categorized with icons to promote easier comprehension of clinical information.
A companion website includes fully searchable online text, interactive cases, USMLE-style questions, and clinical Blue Box video podcasts. Online faculty resources include an Image Bank and a Question Bank.
Product Details

Paperback: 736 pages
Publisher: Lippincott Williams & Wilkins; Fourth, North American Edition edition (January 8, 2010)
Language: English
ISBN-10: 0781799155
ISBN-13: 978-0781799157
Product Dimensions: 10.8 x 8.3 x 1.1 inches
Author: Keith L. Moore, Anne M.R. Agur, Arthur F. Dalley
List Price: $65.95

Cummings: Atlas of Forensic Histopathology

2011-03-15T09:09:00.000-07:00

This histopathologic atlas describes the microscopic changes relevant to the practice of forensic pathology. It guides the forensic pathologist through the issues they will face when determining cause of death. This is essential reading for forensic pathologists, autopsy pathologists, coroners and forensic investigators.

Contents
1. Post injury intervals;
2. Decomposition;
3. Thrombotic and embolic lesions;
4. Aspiration and drowning;
5. Poisoning;
6. Injuries;
7. Sudden death;
8. Pediatrics - special topics;
Index

About the Author

Peter M. Cummings, MD is Medical Examiner and Director of Forensic Neuropathology, Office of the Chief Medical Examiner, Commonwealth of Massachusetts, Boston, MA, USA.
Darin P. Trelka, MD, Ph.D. is Associate Medical Examiner, Broward County Medical Examiner and Trauma Services, FL, USA.
Kimberley M. Springer, MD is Medical Examiner, Office of the Chief Medical Examiner, Commonwealth of Massachusetts, Boston, MA, USA.

Product Details

Hardcover: 200 pages
Publisher: Cambridge University Press; 1 Har/Cdr edition (February 14, 2011)
Language: English
ISBN-10: 0521110890
ISBN-13: 978-0521110891
Product Dimensions: 10.9 x 8.6 x 0.6 inches
Author: Peter M. Cummings, Darin P. Trelka and Kimberley M. Springer
List Price: $125.00

Langman's Medical Embryology 11th Edition

2011-03-14T07:56:00.001-07:00

Widely acclaimed for its clinical relevance and clear writing style, Langman's Medical Embryology provides a user-friendly and innovative approach to learning embryology. The revised eleventh edition presents medical and health professions students with a concise yet thorough description of embryology and its clinical significance, an awareness of which is essential in the diagnosis, and prevention of birth defects. It features outstanding full-color clinical images and photographs, end-of-chapter Summaries, Problems to Solve, and Clinical Correlates boxes.
A companion Website includes fully searchable text, interactive review questions and problems, updated Simbryo animations of embryologic system development, and PowerPoint slides for instructors.

Contents Part 1 General Embryology
Chapter 1 Embryology: Old and New Frontiers and an Introduction to Molecular Regulation and Signaling 3
Clinical Relevance 3
A Brief History of Embryology 4
Introduction to Molecular Regulation and Signaling 5
Chapter 2 Gametogenesis: Conversion of Germ Cells Into Male and Female Gametes 13
Primordial Germ Cells 13
Clinical Correlates 13
The Chromosome Theory of Inheritance 14
Clinical Correlates 16
Morphological Changes During Maturation of the Gametes 24
Clinical Correlates 30
Chapter 3 First Week of Development: Ovulation to Implantation 33
Ovarian Cycle 33
Clinical Correlates 33
Fertilization 36
Clinical Correlates 40
Cleavage 41
Blastocyst Formation 41
Uterus at Time of Implantation 43
Clinical Correlates 43
Chapter 4 Second Week of Development: Bilaminar Germ Disc 47
Day 8 47
Day 9 47
Days 11 and 12 48
Day 13 50
Clinical Correlates 51
Chapter 5 Third Week of Development: Trilaminar Germ Disc 55
Gastrulation: Formation of Embryonic Mesoderm and Endoderm 55
Formation of the Notochord 55
Establishment of the Body Axes 56
Fate Map Established During Gastrulation 61
Growth of the Embryonic Disc 61
Clinical Correlates 61
Further Development of the Trophoblast 63
Chapter 6 Third to Eighth Weeks: The Embryonic Period 67
Derivatives of the Ectodermal Germ Layer 67
Clinical Correlates 73
Derivatives of the Mesodermal Germ Layer 74
Clinical Correlates 81
Derivatives of the Endodermal Germ Layer 82
Patterning of the Anteroposterior Axis: Regulation by Homeobox Genes 84
External Appearance During the Second Month 85
Clinical Correlates 87
Chapter 7Third Month to Birth: The Fetus and Placenta 91
Development of the Fetus 91
Fetal Membranes and Placenta 95
Clinical Correlates 95
Clinical Correlates 97
Structure of the Placenta 100
Clinical Correlates 102
Clinical Correlates 103
Amnion and Umbilical Cord 104
Clinical Correlates 105
Placental Changes at the End of Pregnancy 105
Clinical Correlates 106
Amniotic Fluid 106
Fetal Membranes in Twins 106
Clinical Correlates 109
Parturition (Birth) 111
Clinical Correlates 111
Chapter 8 Birth Defects and Prenatal Diagnosis 113
Birth Defects 113
Clinical Correlates 120
Prenatal Diagnosis 121
Fetal Therapy 123
Part 2 Systems-Based Embryology
Chapter 9 Skeletal System 127
Skull 127
Clinical Correlates 131
Limbs 134
Clinical Correlates 140
Vertebrae and the Vertebral Column 142
Ribs and Sternum 144
Clinical Correlates 144
Clinical Correlates 145
Chapter 10 Muscular System 147
Striated Skeletal Musculature 147
Innervation of Axial Skeletal Muscle 147
Molecular Regulation of Muscle Development 149
Patterning of Muscles 150
Head Musculature 150
Limb Musculature 150
Cardiac Muscle 151
Smooth Muscle 151
Clinical Correlates 152
Chapter 11 Body Cavities 155
Formation of the Intraembryonic Cavity 155
Serous Membranes 155
Clinical Correlates 156
Diaphragm and Thoracic Cavity 159
Formation of the Diaphragm 159
Clinical Correlates 162
Chapter 12 Cardiovascular System 165
Establishment of the Cardiogenic Field 165
Formation and Position of the Heart Tube 165
Formation of the Cardiac Loop 168
Clinical Correlates 170
Molecular Regulation of Cardiac Development 170
Development of the Sinus Venosus 171
Formation of the Cardiac Septa 173
Clinical Correlates 173
Clinical Correlates 177
Clinical Correlates 183
Formation of the Conducting System of the Heart 185
Vascular Development 185
Clinical Correlates 190
Clinical Correlates 195
Circulation Before and After Birth 196
Chapter 13 Respiratory System 201
Formation of the Lung Buds 201
Clinical Correlates 202
Larynx 203
Trachea, Bronchi, and Lungs 203
Maturation of the Lungs 205
Clinical Correlates 206
Chapter 14 Digestive System 209
Divisions of the Gut Tube 209
Molecular Regulation of Gut Tube Development 210
Mesenteries 211
Foregut 212
Clinical Correlates 213
Clinical Correlates 218
Molecular Regulation of Liver Induction 221
Clinical Correlates 221
Pancreas 222
Clinical Correlates 223
Midgut 223
Clinical Correlates 227
Hindgut 230
Clinical Correlates 231
Chapter 15 Urogenital System 235
Urinary System 235
Clinical Correlates 240
Clinical Correlates 242
Clinical Correlates 245
Genital System 246
Clinical Correlates 254
Clinical Correlates 257
Clinical Correlates 258
Clinical Correlates 262
Chapter 16 Head and Neck 265
Pharyngeal Arches 267
Pharyngeal Pouches 271
Pharyngeal Clefts 273
Molecular Regulation of Facial Development 273
Clinical Correlates 275
Tongue 277
Clinical Correlates 278
Thyroid Gland 278
Clinical Correlates 279
Face 280
Intermaxillary Segment 282
Secondary Palate 283
Clinical Correlates 284
Nasal Cavities 287
Teeth 287
Molecular Regulation of Tooth Development 290
Clinical Correlates 290
Chapter 17 Central Nervous System 293
Spinal Cord 294
Clinical Correlates 302
Brain 303
Clinical Correlates 310
Molecular Regulation of Brain Development 313
Clinical Correlates 315
Cranial Nerves 319
Autonomic Nervous System 319
Clinical Correlates 323
Chapter 18 Ear 327
Internal Ear 327
Middle Ear 330
External Ear 332
Clinical Correlates 333
Chapter 19 Eye 335
Optic Cup and Lens Vesicle 335
Retina, Iris, and Ciliary Body 337
Lens 339
Choroid, Sclera, and Cornea 339
Vitreous Body 339
Optic Nerve 340
Molecular Regulation of Eye Development 340
Clinical Correlates 342
Chapter 20 Integumentary System 345
Skin 345
Clinical Correlates 346
Clinical Correlates 346
Hair 347
Clinical Correlates 348
Sweat Glands 348
Mammary Glands 348
Clinical Correlates 349
Part 3 Appendix
Answers to Problems 353
Glossary of Key Terms 362
Figure Credits 369
Index 373

Product Details

Paperback: 385 pages
Publisher: Lippincott Williams & Wilkins; Eleventh, North American Edition edition (January 30, 2009)
Language: English
ISBN-10: 0781790697
ISBN-13: 978-0781790697
Product Dimensions: 9.9 x 6.9 x 0.6 inches
List Price: $63.95

Dudek: High-Yield Histopathology 2nd Edition

2011-03-13T09:03:00.000-07:00

High-Yield Histopathology reviews the relationships of basic histology to the pathology, physiology, and pharmacology of clinical conditions that are tested on the USMLE Step 1 and seen in clinical practice. The book includes case studies that prepare students for the clinical vignette questions on the USMLE Step 1 along with numerous illustrations, clinical images, and tables for reference and study. This edition includes additional information on male and female tumours and breast cancer, new images of clinical conditions, and several new tables, line drawings, and graphs. The figure legends and text are more succinct, and the Clinical Considerations sections are more consistently organized - characteristics, symptoms, diagnosis, and treatment.

Book Features

NEW! addition of information on male and female tumours to Chapters 26 and 27;
NEW! additional information on breast cancer in Chapter 26;
NEW! approximately 15 new images of clinical conditions;
NEW! approximately 5 additional tables and modifications to other tables;
NEW! approximately 5 new line drawings or graphs;
NEW! improved, more consistent organization for the Clinical Considerations: Characteristics, Symptoms, Diagnosis & Treatment;
NEW! shortened figure legends as well as reductions in text to be more concise (high-yield) & correlation of basic histology with pathology and physiology concepts.

Contents

Part 1 Nucleus

1. Nuclear Envelope
2. Apoptosis
3. Nucleolus
4. Chromatin
5. Chromosomes
6. Types of DNA Damage and DNA Repair
7. Clinical Importance of DNA Repair
8. Cell Cycle
9. Proto-Oncogenes and Oncogenes
10. Tumor Suppressor Genes
11. Oncofetal Antigens and Tumor Markers
12. Transcription in Protein Synthesis
13. Processing the RNA Transcript into mRNA
14. Selected Photomicrographs

Part 2 Cytoplasm and Organelles

1. Cytoplasm
2. Ribosomes
3. Rough Endoplasmic Reticulum (rER)
4. Translation
5. Golgi Complex
6. Smooth Endoplasmic Reticulum (sER)
7. Mitochondria
8. Lysosomes
9. Peroxisomes
10. Cytoskeleton
11. Lipofuscin .
12. Hemosiderin
13. Glycogen
14. Selected Photomicrographs

Part 3 The Cell Membrane: Eicosanoids and Receptors/Signal Transduction

1. The Lipid Component of the Cell Membrane
2. The Protein Component of the Cell Membrane
3. Membrane Transport Proteins
4. G Protein–linked Receptors
5. Types of G Protein–linked Receptors
6. Enzyme–linked Receptors
7. Low–density Lipoprotein (LDL) Receptor

Part 4 Epithelium

1. Introduction
2. Classification of Epithelium
3. Apical Region
4. Lateral Region
5. Basal Region
6. Clinical Considerations
7. Selected Photomicrographs

Part 5 Connective Tissue

1. Introduction
2. Ground Substance
3. Fibers
4. Cells
5. Clinical Considerations
6. Selected Photomicrographs

Part 6 Cartilage

1. Introduction
2. Ground Substance
3. Fibers
4. Cells
5. Blood Vessels and Nerves
6. Chondrogenesis
7. Hormonal Influence
8. Repair

Part 7 Bone

1. Introduction .
2. Ground Substance
3. Fiber

Product Details

Paperback: 328 pages
Publisher: Lippincott Williams & Wilkins; 2 edition (October 31, 2010)
Language: English
ISBN-10: 1609130154
ISBN-13: 978-1609130152
Product Dimensions: 9.9 x 7 x 0.6 inches

List Price: $29.95

Saladin: Human Anatomy 3rd edition

2011-03-11T07:37:00.000-08:00

Read it, See it, Master it!

Read it- Ken Saladin explains human anatomy in an engaging, yet efficient way. He puts a premium on the words, and uses student-relevant analogies to motivate the reader.
See it- Saladin’s collection of illustrations and photos are carefully chosen to support the text discussion. Vibrant and realistic presentations engage students.
Master it- With Connect and A&P Revealed, students can practice and improve their understanding of concepts.

From the most pedagogically sound organization to the exceptional art, to the integration of text with technology, Saladin has formed a teaching system that will both motivate and enable students to understand and appreciate the wonders of human anatomy. This distinctive text was developed to stand apart from all other anatomy texts with an approach borne out of more than 30 years of teaching, unparalleled art, and a writing style that has been acclaimed by reviewers. Designed for a one-semester college anatomy course, Saladin requires no prior knowledge of chemistry or cell biology.

Contents Part 1 Organization of the Body
1 The Study of Human Anatomy
2 Cytology—The Study of Cells
3 Histology—The Study of Tissues
4 Human Development
Part 2 Support and Movement
5 The Integumentary System
6 Bone Tissue
7 The Axial Skeleton
8 The Appendicular Skeleton
9 Joints
10 The Muscular System—Introduction
11 The Axial Musculature
12 The Appendicular Musculature Atlas of Regional and Surface Anatomy
Part 3 Integration and Control
13 Nervous Tissue
14 The Spinal Cord and Spinal Nerves
15 The Brain and Cranial Nerves
16 The Autonomic Nervous System and Visceral Reflexes
17 Sense Organs
18 The Endocrine System
Part 4 Maintenance
19 The Circulatory System I—Blood
20 The Circulatory System II—The Heart
21 The Circulatory System III—Blood Vessels
22 The Lymphatic System and Immunity
23 The Respiratory System
24 The Digestive System
25 The Urinary System
Part 5 Reproduction
26 The Reproductive System
Appendix: Answers to Chapter Review Questions
Glossary
Credits
Index

About the Author
Kenneth S. Saladin is a full professor at Georgia College and State University. He obtained his B.S. degree in Zoology from Michigan State University and his Ph.D. in Biological Sciences from Florida State University. He has taught both undergraduate and graduate courses for over twenty years.

Product Details

Hardcover: 864 pages
Publisher: McGraw-Hill Science/Engineering/Math; 3 edition (January 13, 2010)
Language: English
ISBN-10: 0077349997
ISBN-13: 978-0077349998
Product Dimensions: 11.1 x 8.9 x 1.3 inches
List Price: $152.83
Author: Kenneth S. Saladin

Plotkin: Vaccines 5th edition: Expert Consult, Online + Print

2011-03-10T07:48:00.000-08:00

Completely revised and updated, Vaccines by Stanley A. Plotkin, Walter Orenstein and Paul A. Offit offers comprehensive and current coverage of every aspect of vaccination-from development to use in reducing disease. It provides authoritative information on vaccine production, available preparations, efficacy, and safety.recommendations for vaccine use, with rationales.data on the impact of vaccination programs on morbidity and mortality.and more. And now, as an Expert Consult title, it includes a companion web site offering this unparalleled guidance where and when you need it most!

Book Features

Provides a complete understanding of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well an epidemiology and public health issues.
Offers comprehensive coverage of both existing vaccines and vaccines currently in the research and development stage.
Examines vaccine stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease control strategies.
Analyses the cost-benefit and cost-effectiveness of vaccines.
Discusses the proper use of immune globulins and antitoxins.
Illustrates concepts and objective data with approximately 600 tables and figures.

New in this edition

Includes access to a companion web site offering the complete contents of the book - fully searchable - for rapid consultation from anyplace with an Internet connection.

Contents

A Short History of Vaccination
The History of Polio Vaccine Development
The Immunology of Vaccination
The Vaccine Industry
Vaccine Manufacturing
Immunologic Adjuvants
Vaccine Additives and Manufacturing Residuals in the United States - Licensed Vaccines
General Immunization Practices
Smallpox and Vaccinia
Vaccination in the Immunocompromised Host
Vaccination of Human Immunodeficiency Virus-Infected Persons
Bacille Calmette-Guerin Vaccine
Diphtheria Toxoid
Haemophilus influenzae Vaccine
Hepatitis A Vaccine
Hepatitis B Vaccine
Influenza Vaccine - Inactivated
Influenza Vaccine - Live
Measles Vaccine
Mumps Vaccine
Pertussis Vaccine
Pneumococcal Polysaccharide
Pneumococcal Conjugate Vaccine
Poliovirus Vaccine - Inactivated
Poliovirus Vaccine - Live
Rubella Vaccine
Tetanus Toxoid
Varicella Vaccine
Combination Vaccines
Adenovirus Vaccine
Anthrax Vaccine
Cholera Vaccine
Japanese Encephalitis Vaccines
Meningococcal Vaccines
Miscellaneous Limited-Use Vaccines
Plague
Rabies Vaccine
Tick-Borne Encephalitis Virus Vaccine
Typhoid Fever Vaccine
Yellow Fever Vaccine
Technologies for Making New Vaccines
Cytomegalovirus and Herpes Simplex Vaccines
Diarrheal Disease Vaccines
Human Immunodeficiency Virus
Human Papillomavirus Vaccine for Cervical Cancer Prevention
Lyme Disease Vaccine
Malaria Vaccine
Parasitic Disease Vaccines
Poxviruses as Immunization Vehicles
Respiratory Syncytial Virus Vaccine
Rotavirus Vaccine
Staphylococcus Vaccine
Immunization in the United States
Immunization in Europe
Vaccination Programs in Developing Countries
Community Immunity
Economic Analyses of Vaccine Policies
Vaccines for International Travel
Vaccines for Health Care Workers
Regulation and Testing of Vaccines
Safety of Immunizations
Multiple Vaccines and the Immune System
Legal Issues

App. 1 Recommendations of the Advisory Committee on Immunization Practices
App. 2 Immunobiologicals and Their Manufacturers and Distributors
App. 3 Representative Vaccine Information Statement
App. 4 Case Definitions for Selected Vaccine-Preventable Diseases Under Public Health Surveillance in the United States
App. 5 Web Sites that Contain Information About Immunization
List of Previous Authors
Index

Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

Product Details

Hardcover: 1748 pages
Publisher: Saunders; 5 edition (February 7, 2008)
Language: English
ISBN-10: 1416036113
ISBN-13: 978-1416036111
Product Dimensions: 11.2 x 9.1 x 2.4 inches
List Price: $355.00

Martini: Human Anatomy 7th Edition

2011-03-09T07:20:00.000-08:00

Celebrated for its atlas-style format, appropriately detailed anatomical illustrations, and exceptionally clear photographs of tissues and cadavers, the Seventh Edition of the award-winning Human Anatomy presents practical applications of anatomy and physiology in a highly visual format. Select Clinical Notes feature dynamic layouts that integrate text with visuals for easy reading. Clinical Cases relate clinical stories that integrate text with patient photos and diagnostic images for applied learning. Time-saving study tools, including end-of-chapter practice and review, help students arrive at a complete understanding of human anatomy.
A comprehensive introduction to human anatomy for students majoring in biology or fulfilling prerequisites for nursing, allied health, or pre-med programs. The book has an outstanding art program that combines award-winning medical illustrations by William Ober, M.D. and cadaver and bone photos by the renown biomedical photographer Ralth Hutchings. The text also includes innovative pedagogical elements which make this book the clear choice for introductory anatomy courses.

Contents

An Introduction to Anatomy
The Cell
The Tissue Level of Organization
The Integumentary System
The Skeletal System: Osseous Tissue and Skeletal Structure
The Skeletal System: Axial Division
The Skeletal System: Appendicular Division
The Skeletal System: Articulations
The Muscular System: Skeletal Muscle Tissue
The Muscular System: Muscle Organization and the Axial Musculature
The Muscular System: The Appendicular Musculature
Surface Anatomy
The Nervous System: Neural Tissue
The Nervous System: The Spinal Cord and Spinal Nerves
The Nervous System: The Brain and Cranial Nerves
The Nervous System: Pathways and Higher-Order Functions
The Nervous System: Autonomic Division
The Nervous System: General and Special Senses
The Endocrine System
The Cardiovascular System: Blood
The Cardiovascular System: The Heart
The Cardiovascular System: Vessels and Circulation
The Lymphatic System
The Respiratory System
The Digestive System
The Urinary System
The Reproductive System
Human Development

About the Author

Dr. Frederic (Ric) Martini received his Ph.D. from Cornell University in comparative and functional anatomy for work on the pathophysiology of stress. His publications include journal articles and contributed chapters, technical reports, and magazine articles. He is the lead author of six other undergraduate texts on anatomy and physiology or anatomy, and has a feature column, “Back to Basics,” in Physician License and Practice Today, a quarterly publication for medical students and residents. He is currently affiliated faculty of the University of Hawaii at Manoa and remains connected with the Shoals Marine Laboratory, a joint venture between Cornell University and the University of New Hampshire. Dr. Martini has been active in the Human Anatomy and Physiology Society (HAPS) for 15 years, and was a member of the committee that established the course curriculum guidelines for A&P. He is now a President Emeritus of HAPS after serving as President-Elect, President, and Past-President over 2004—2007. He is also a member of the American Physiological Society, the American Association of Anatomists, the Society for Integrative and Comparative Biology, the Australia/New Zealand Association of Clinical Anatomists, the Hawaii Academy of Science, the American Association for the Advancement of Science, and the International Society of Vertebrate Morphologists.
Dr. Michael J. Timmons received his degrees from Loyola University, Chicago. For more than three decades he has had a strong commitment to teaching nursing and pre-professional students at Moraine Valley Community College. In 2005—2006 Professor Timmons was honored with the Professor of the Year Award by Moraine Valley College and the Excellence Award from the National Institute for Staff and Organizational Development for his outstanding contributions to teaching, leadership, and student learning. He was the recipient of the Excellence in Teaching Award by the Illinois Community College Board of Trustees. Professor Timmons has authored several anatomy and physiology lab manuals and dissection guides. His areas of interest include biomedical photography, crafting illustration programs, and developing instructional technology learning systems. He chaired the Midwest Regional Human Anatomy and Physiology Conference and is also a national and regional presenter at the League for Innovation Conferences on Information Technology for Colleges and Universities and at Human Anatomy and Physiology Society meetings.
Dr. Robert B. Tallitsch received his Ph.D. in physiology with an anatomy minor from the University of Wisconsin–Madison at the ripe old age of 24. Since then, Dr. Tallitsch has been on the biology faculty at Augustana College in Rock Island, Illinois. His teaching responsibilities include Human Anatomy, Neuroanatomy, Histology, and Kinesiology. He is also a member of the Asian Studies faculty atAugustana College and teaches a course in Traditional Chinese Medicine. In seven out of the last nine years, Dr. Tallitsch has been designated as one of the “unofficial teachers of the year” by the graduating seniors at Augustana College. Dr. Tallitsch is a member of the American Physiological Society, American Association of Anatomists, AsiaNetwork, and the Human Anatomy and Physiology Society. In addition to his teaching responsibilities at Augustana College, Dr. Tallitsch has served as a visiting faculty member at the Foreign Languages Faculty at the Beijing University of Chinese Medicine and Pharmacology (Beijing, PRC), and the Foreign Languages Faculty at Central ChinaNormalUniversity (Wuhan, PRC).

Product Details

Author: Frederic H. Martini, Michael J. Timmons and Robert B. Tallitsch
Hardcover: 904 pages
Publisher: Benjamin Cummings; 7 edition (January 24, 2011)
Language: English
ISBN-10: 0321688155
ISBN-13: 978-0321688156
Product Dimensions: 12.1 x 10.7 x 1.4 inches
List Price: $213.60

Cibas: Cytology: Diagnostic Principles and Clinical Correlates 3rd edition, Expert Consult - Online and Print

2011-03-08T07:30:00.000-08:00

Cytology: Diagnostic Principles and Clinical Correlates 3rd edition examines the latest diagnostic techniques for the interpretation of a complete range of cytological specimens. It is concise, yet covers all of the organ systems in which the procedure is used, with the number of pages devoted to each body site proportional to the clinical relevance of cytology for that site. Inside, you'll find new information on ductal lavage cytology and expanded coverage of FNA performance, keeping you current with the newest procedures. Over 700 full-color illustrations provide you with a real-life perspective of a full range of cytologic findings. Each chapter includes a discussion of indications and methods, along with a section on differential diagnosis accompanied by ancillary diagnostic techniques such as immunohistochemistry and molecular biology, where appropriate. As an Expert Consult title, it includes online access to the complete text of the book, fully searchable-as well as all of the images downloadable for your personal use-at www.expertconsult.com.

Book Features

Offers comprehensive coverage of everyday diagnostic work in a concise format for a practical benchside manual.
Covers every type of cytology-gynecology, non-gynecology, and FNA.
Presents an in-depth differential diagnosis discussion for all major entities.
Examines the role of special techniques such as immunohistochemistry, flow cytometry, and molecular biology in resolving difficulties in interpretation and diagnosis.
Provides an in-depth analysis of common diagnostic pitfalls to assist with daily signing out and reporting.
Features coverage of patient management in discussions of pertinent clinical features.
Uses capsule summaries featuring easy-to-read bulleted text that provide a quick review of key differential diagnoses, diagnostic pitfalls, cytomorphologic features, and tissue acquisition protocols for specific entities.
Includes over 700 full-color illustrations that provide you with a real-life perspective of a full range of cytologic findings.
Features anytime, anywhere online access to the complete text of the book, fully searchable-as well as all of the images downloadable for your personal use-at www.expertconsult.com.
Covers automated cytology and HPV testing in Cervical and Vaginal Cytology chapter, providing an up-to-date reference on the techniques used in today's labs.
Offers new information on ductal lavage cytology and expanded coverage of FNA performance, keeping you current with the newest procedures.
Discusses the implementation of proficiency testing and changes in laboratory inspection and accreditation.
Includes recommendations from the 2008 National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference.

Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

Contents
1. Cervical and Vaginal Cytology
2. Respiratory Tract
3. Urine and Bladder Washings
4. Pleural, Pericardial, and Peritoneal Fluids
5. Peritoneal Washings
6. Cerebrospinal Fluid
7. Gastrointestinal Tract
8. Breast
9. Thyroid, Edmund S. Cibas
10. Salivary Gland
11. Lymph Nodes
12. Liver
13. Pancreas and Biliary Tree
14. Kidney and Adrenal Gland
15. Ovary
16. Soft Tissue
17. Laboratory Management
Index

About the Author

Edmund S Cibas, MD, Assistant Professor of Pathology, Harvard Medical School; Director, Division of Cytology, Department of Pathology, Brigham and Women's Hospital, Boston, MA; and
Barbara S. Ducatman, MD, Clinical Professor of Pathology, West Virginia University, Morgantown, West Virginia.

Product Details

Hardcover: 552 pages
Publisher: Saunders; 3 edition (January 20, 2009)
Language: English
ISBN-10: 1416053298
ISBN-13: 978-1416053293
Product Dimensions: 11 x 8.8 x 1 inches
Author: Edmund S. Cibas and Barbara S. Ducatman
List Price: $185.00

Marieb: Human Anatomy 6th Edition

2011-03-07T07:18:00.000-08:00

Human Anatomy, Sixth Edition builds upon the clear and concise explanations of the best-selling Fifth Edition. A dramatically improved art and photo program, even clearer explanations and readability, and more integrated clinical coverage are all included. Recognized for helping you establish the framework needed for understanding how anatomical structure relates to function, the text’s engaging descriptions now benefit from a brand-new art program that features vibrant, saturated colors as well as new side-by-side cadaver photos. New Focus figures have been added to help you grasp the most difficult topics in anatomy.
Human Anatomy, Third Edition, uses a functional approach that explains how the shape and composition of anatomical structures allow them to perform their functions, giving readers the framework they need to assimilate anatomical concepts and apply them to new situations. In addition, the book is distinguished by a newly revised art program that brilliantly illuminates the complexities of human anatomy, and a writing style that is clear, informal, and accessible. For this edition, a comprehensive electronic supplements package has been crafted with the same careful attention to accuracy and teaching effectiveness found in the book. For college instructors and students.

Contents
1 The Human Body: An Orientation
2 Cells: The Living Units
3 Basic Embryology
4 Tissues
5 The Integumentary System
6 Bones and Skeletal Tissues
7 Bones of the Skeleton
8 Joints
9 Muscle Tissue
10 Muscles of the Body
11 Fundamentals of the Nervous System and Nervous Tissue
12 The Central Nervous System
13 The Peripheral Nervous System
14 The Autonomic Nervous System and Visceral Sensory Neurons
15 The Special Senses
16 Blood
17 The Heart
18 Blood Vessels
19 The Lymphatic System
20 The Respiratory System
21 The Digestive System
22 The Urinary System
23 The Reproductive System
24 The Endocrine System
25 Surface Anatomy
Appendix A The Metric System
Appendix B Answers to Multiple Choice and Matching Questions
Appendix C Word Roots, Prefixes, Suffixes, Combining Forms
Glossary
Credits
Index

Product Details

Author: Elaine N. Marieb, Patricia Brady Wilhelm and Jon B. Mallatt
Hardcover: 880 pages
Publisher: Benjamin Cummings; 6 edition (January 17, 2010)
Language: English
ISBN-10: 0321616111
ISBN-13: 978-0321616111
Product Dimensions: 10.9 x 9.2 x 1.2 inches
List Price: $218.67

Differential Diagnosis in Surgical Pathology: Expert Consult - Online and Print

2011-03-02T11:08:00.000-08:00

Differential Diagnosis in Surgical Pathology, 2nd Edition, by Paolo Gattuso, MD, Vijaya B. Reddy, MD, Odile David, MD, and Daniel J. Spitz, MD, is skillfully designed to help you confidently sign out your most complex and challenging cases. Covering a complete range of tumors and tumor-like conditions in all organ systems, it provides a user-friendly road map to the main criteria you should consider in order to differentiate between a variety of potential diagnoses that all have a very similar appearance. Over 1,350 new full-color macro- and microphotographs provide a realistic basis for comparison to what you see under the microscope. Quick checklists cover all diagnostic possibilities to make sure nothing falls through the cracks. Full-text online access at expertconsult.com allows you to reference the book from any computer and download all of its images.

Book Features

A concise, bulleted textual format facilitates quick retrieval of essential facts.
A consistent approach to diagnosis and interpretation expedites reference.
Coverage of all relevant ancillary diagnostic techniques addresses all of the investigative contexts needed to formulate an accurate diagnosis.
Expert "pearls" offer practical tips on what diagnostic criteria to consider or exclude.
A comprehensive, yet manageable size allows for quick consultation.

New in this edition

Online access at expertconsult.com allows you to quickly consult the book from any computer and download all of its images.
Over 1,350 new full-color macro- and microphotographs provide a realistic basis for comparison to what you see under the microscope.
Immunohistochemical and molecular techniques throughout enable you to review all of the latest diagnostic considerations in one place.
Expanded coverage of non-neoplastic entities assists you in recognizing benign lesions that may mimic the appearance and characteristics of malignant ones.
Extensive updates include the latest classification schemes and relevant diagnostic techniques.
A brand-new, color-coded layout highlights key points more clearly and helps you turn to the sections you need more speedily.

Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

About the Author

Meryl Haber, MD, Rush Med Ctr, Chicago, IL; P. Guttuso, MD, Rush Med Ctr, Chicago, IL; O. David, MD, Tulane U. Med School, New Orleans, LA; D. Spitz, MD, Miami-Dade County Examiner Dep., Miami, FL; T. Betlej, MD, Riverside Med Ctr, Kankakee, IL.

Book Details

Hardcover: 1128 pages
Publisher: Saunders; 2 edition (October 19, 2009)
Language: English
ISBN-10: 1416045805
ISBN-13: 978-1416045809
Product Dimensions: 11.1 x 8.9 x 2 inches
List Price: $207.00

Physician Assistant Board Review: Expert Consult - Online and Print

2011-03-01T02:20:00.000-08:00

As the PANRE and PANCE change, so does the material you need to prepare for them. Ace the boards using James Van Rhee's Physician Assistant Board Review, 2nd Edition, with updated content and new practice-focused questions. You'll find comprehensive, current material on all topics and brand-new sections on pediatrics and lab medicine. Practice makes perfect, so test yourself online and in print with three different 300-question simulations of the Boards.

Book Features

Simplify preparation for the boards by studying this well-organized, test-question format.
Access the web site containing questions and rationales specific to the new PANRE.

New in this edition

Prepare for the new practice-focused questions.
Gain a more comprehensive understanding of hypertension and diabetes treatment with additional content that better reflects the new board questions.
Get expanded guidance on pediatrics and laboratory medicine with brand-new material on these subjects.
Improve your test-taking skills with new sections discussing various techniques to increase your score.
Test yourself online with two fantastic 300-question timed exam simulators on Expert Consult.

Ace the boards with comprehensive text and online exam simulator.

Contents
Chapter 1 Cardiovascular System
Chapter 2 Pulmonary System
Chapter 3 Gastroenterology System
Chapter 4 Musculoskeletal System
Chapter 5 Eyes, Ears, Nose, and Throat System
Chapter 6 Reproductive System
Chapter 7 Endocrine System
Chapter 8 Neurologic System
Chapter 9 Psychiatry/Behavioral Science
Chapter 10 The Genitourinary System
Chapter 11 Dermatologic System
Chapter 12 The Hematologic System
Chapter 13 Infectious Disease
Appendices
Appendix 1 Pediatric Milestones
Appendix 2 Common Signs in Medicine
Appendix 3 Common Dermatomes
Appendix 4 Cranial Nerves and Function
Appendix 5 Apgar Scoring
Appendix 6 Poisoning Antidotes
Appendix 7 Secondary Prevention of Common Cancer in Average-Risk Patients
Appendix 8 Normal Laboratory Values
Test Taking Strategies
Index

Product Details

Paperback: 456 pages
Publisher: Saunders; 2 edition (April 19, 2010)
Language: English
ISBN-10: 1437700004
ISBN-13: 978-1437700008
Product Dimensions: 10.8 x 8.5 x 0.5 inches
List Price: $64.95

Sternberg's Diagnostic Surgical Pathology 5th edition 2 Volume Set

2011-02-28T11:04:00.000-08:00

Completely updated, the Fifth Edition of this standard-setting two-volume reference presents the most advanced diagnostic techniques and the latest information on all currently known disease entities. More than 90 preeminent surgical pathologists offer expert advice on the diagnostic evaluation of every type of specimen from every anatomic site. The Fifth Edition contains over 4,400 full-color photographs.

This edition provides detailed coverage of the latest developments in the field, including new molecular and immunohistochemical markers for diagnosis and prognosis of neoplasia, improved classification systems for diagnosis and prognosis, the role of pathology in new diagnostic and therapeutic techniques, and the recognition of new entities or variants of entities. Where appropriate updated World Health Organization (WHO) terminology has been employed for tumor diagnosis.

Book Features

An update on the serrated adenoma and serrated carcinoma pathway.
Virtually new chapters on salivary gland, larynx, blood vessels, heart, non-melanocytic skin tumors, and placenta.
Complete updates of the lymph node and bone marrow chapters incorporating the new WHO terminology.
An expanded discussion of the molecular biology of thyroid neoplasia.
All full-color illustrations have been color-balanced to dramatically improve image quality.
A companion Website will include the fully searchable text and an image bank.

Book Details

Hardcover: 3104 pages
Publisher: Lippincott Williams & Wilkins; Fifth edition (August 24, 2009)
Language: English
ISBN-10: 0781779421
ISBN-13: 978-0781779425
Product Dimensions: 12.4 x 10.2 x 5.7 inches

Cooper: The Cell A Molecular Approach 5th Edition

2011-02-27T01:47:00.000-08:00

The Cell A Molecular Approach 5th Edition presents current comprehensive science in a readable and cohesive text that students can master in the course of one semester. This new edition retains the overall organization, themes, and special features of the Fourth Edition, including Key Experiment and Molecular Medicine essays, chapter sidebars that highlight areas of interest and clinical applications, and end-of-chapter questions with answers at the back of the book. The Fifth Edition has been updated throughout to reflect major advances since publication of the Fourth Edition in 2006, including:

Advances in understanding gene regulation by microRNAs
Histones and epigenetic inheritance
Identification of human disease susceptibility genes by genome-wide association scans
Protein import into mitochondria
Induced pluripotent stem cells
Role of autophagy in programmed cell death
Genomic analysis of mutations in human cancers
New Key Experiments: RNA Interference (Chapter 4) and G Protein-Coupled Receptors and Odor Detection (Chapter 15)

Contents
1 An overview of cells and cell research
2 The composition of cells
3 Cell metabolism
4 Fundamentals of molecular biology
5 The organization and sequences of cellular genomes
6 Replication, maintenance, and rearrangements of genomic DNA
7 RNA synthesis and processing
8 Protein synthesis, processing, and regulation
9 The nucleus
10 Protein sorting and transport : the endoplasmic reticulum, Golgi apparatus, and lysosomes
11 Bioenergetics and metabolism : mitochondria, chloroplasts, and peroxisomes
12 The cytoskeleton and cell movement
13 The plasma membrane
14 Cell walls, the extracellular matrix, and cell interactions
15 Cell signaling
16 The cell cycle
17 Cell death and cell renewal
18 Cancer

Product Details

Hardcover: 765 pages
Publisher: Sinauer Associates Inc.; 5th edition (March 31, 2009)
Language: English
ISBN-10: 087893300X
ISBN-13: 978-0878933006
Product Dimensions: 10.9 x 8.6 x 1.7 inches
List Price: $127.95

Essential Cell Biology 3rd edition

2011-02-26T01:58:00.000-08:00

Essential Cell Biology provides an accessible introduction to the fundamental concepts of cell biology. Its lively writing and exceptional illustrations make it the ideal textbook for a first course in cell and molecular biology. The text and figures are easy-to-follow, accurate, clear, and engaging for the introductory student. Molecular detail has been kept to a minimum in order to provide the reader with a cohesive, conceptual framework of the basic science that underlies our current understanding of biology.

The Third Edition is thoroughly updated scientifically, yet maintains the academic level and size of the previous edition. The book is accompanied by a Media DVD-ROM with over 130 animations and videos, all the figures from the book, and a new self-test quizzing feature for students.

Contents

Ch. 1 Introduction to Cells
Ch. 2 Chemical Components of Cells
Ch. 3 Energy, Catalysis, and Biosynthesis
Ch. 4 Protein Structure and Function
Ch. 5 DNA and Chromosomes
Ch. 6 DNA Replication, Repair, and Recombination
Ch. 7 From DNA to Protein: How Cells Read the Genome
Ch. 8 Control of Gene Expression
Ch. 9 How Genes and Genomes Evolve
Ch. 10 Manipulating Genes and Cells
Ch. 11 Membrane Structure
Ch. 12 Membrane Transport
Ch. 13 How Cells Obtain Energy from Food
Ch. 14 Energy Generation in Mitochondria and Chloroplasts
Ch. 15 Intracellular Compartments and Transport
Ch. 16 Cell Communication
Ch. 17 Cytoskeleton
Ch. 18 Cell-Cycle Control and Cell Death
Ch. 19 Cell Division
Ch. 20 Genetics, Meiosis, and the Molecular Basis of Heredity
Ch. 21 Tissues and Cancer

About the Author

Bruce Alberts received his Ph.D. from Harvard University and is Professor of Biochemistry and Biophysics at the University of California, San Francisco. He is the editor-in-chief of Science magazine. For 12 years he served as President of the U.S. National Academy of Sciences (1993-2005).
Dennis Bray received his Ph.D. from Massachusetts Institute of Technology and is currently an active emeritus professor at University of Cambridge. In 2006 he was awarded the Microsoft European Science Award.
Karen Hopkin received her Ph.D. in biochemistry from the Albert Einstein College of Medicine and is a science writer in Somerville, Massachusetts.
Alexander Johnson received his Ph.D. from Harvard University and is Professor of Microbiology and Immunology and Director of the Biochemistry, Cell Biology, Genetics, and Developmental Biology Graduate Program at the University of California, San Francisco.
Julian Lewis received his D.Phil. from the University of Oxford and is a Principal Scientist at the London Research Institute of Cancer Research UK.
Martin Raff received his M.D. from McGill University and is at the Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit and in the Biology Department at University College London.
Keith Roberts received his Ph.D. from the University of Cambridge and is Emeritus Fellow at the John Innes Centre, Norwich.
Peter Walter received his Ph.D. from The Rockefeller University in New York and is Professor and Chairman of the Department of Biochemistry and Biophysics at the University of California, San Francisco, and an Investigator of the Howard Hughes Medical Institute.

Product Details

Hardcover: 860 pages
Publisher: Garland Science; 3 edition (March 27, 2009)
Language: English
ISBN-10: 0815341296
ISBN-13: 978-0815341291
Product Dimensions: 11 x 8.6 x 1.4 inches
List Price: $144.00

Dabbs: Diagnostic Immunohistochemistry: Theranostic and Genomic Applications 3rd edition Expert Consult: Online and Print

2011-02-25T11:01:00.000-08:00

Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin's lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. The fully searchable text is also available online at expertconsult.com, along with a downloadable image bank and access to Path Consult. This concise and complete resource is today's indispensable guide to the effective use of immunohistochemical diagnosis.

Book Features

Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses.
Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization.
Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors.
Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance.
Features an expert author for each chapter to ensure coverage of the current state of the art.

New in this edition

Includes access to the full text online at expertconsult.com, along with a downloadable image bank and Path Consult.
Provides guidance on the role of genomics in identifying genetic and molecular aspects of disease that may affect patient care and therapeutic approaches.
Covers theranostic applications to enable you to evaluate therapeutic choices based on immunohistochemical results.
Reflects the latest developments in the field through new chapters on molecular anatomic pathology and immunocytology, as well as updated chapters on immunohistology of the prostate, bladder, testis, and kidney and Non-Hodgkin's lymphoma.
Discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval.
Presents key differential diagnoses boxes that provide tabular summaries of DDx and algorithms.
Features discussions of ancillary anatomic molecular diagnostics as an adjunct to immunohistochemistry for a more well-rounded diagnostic approach.

Accurately interpret immunohistochemical results and provide the clinician with the best therapeutic approaches for the patient
Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

Book Details

Hardcover: 960 pages
Publisher: Saunders; 3 edition (January 29, 2010)
Language: English
ISBN-10: 1416057668
ISBN-13: 978-1416057666
Product Dimensions: 11.2 x 8.9 x 1.7 inches

Kryger: Atlas of Clinical Sleep Medicine: Expert consult - Online and Print

2011-02-24T02:14:00.000-08:00

From Meir H. Kryger, MD, the editor of the definitive resource in sleep, Principles and Practice of Sleep Medicine, comes the Atlas of Clinical Sleep Medicine. This highly illustrated atlas provides you with an exceptional visual aid to the most comprehensive, authoritative, and up-to-date information for diagnosing and treating adult and pediatric patients with sleep disorders. It is the first atlas that uses the new scoring rules, and reviews how to use the new AASM scoring manual that helps you score, interpret, and diagnose sleep disorders.

Each chapter details the physiologic, clinical, morphologic, and investigational aspects of the full range of sleep disorders you encounter in everyday practice. Clinical information is presented in an easy-to-understand style, and the integration of color offers increased visual guidance. Plus, with Expert Consult functionality, you'll have easy access to the full text online, as well as all of the book's illustrations, more than 20 videos of patient interviews, over 40 sleep lab videos, and 200 plus polysomnogram fragments at expertconsult.com.

Book Features

Includes access to the full-text online at expertconsult.com, as well as all of the book's illustrations, more than 20 videos of patient interviews, including narcolepsy and restless leg syndrome, over 40 sleep lab videos, including obstructive sleep apnea and respiratory diseases, and 200 plus polysomnogram fragments.
Uses the new scoring rules, and reviews how to use the new AASM scoring manual that helps you score, interpret, and diagnose sleep disorders.
Covers the full range of sleep disorders so you can diagnose any condition you see.
Features discussions of pediatric conditions such as pediatric congenital diseases so you can better diagnose and treat this special group.
Contains a wealth of high-quality polysomnograms taken from the latest machines used by institutions around the world.
Emphasizes pharmacology and includes information about the latest drugs available as well as those in clinical trials to help you determine the best and most up-to-date drug therapy.
Uses images and drawings to effectively describe the physiology of sleep medicine to help make difficult concepts easier to grasp.
Offers a full-color compendium that combines the physiology of sleep with the relevant findings to present a complete picture of how sleep affects each body system.
Uses a consistent, easy-to-follow chapter format that makes reference easy.

About the Author
Meir H. Kryger, MD, FRCPC, Professor of Medicine, University of Connecticut, Director of Research and Education, Gaylord Hospital Sleep Medicine, Wallingford , Connecticut.

Product Details

Hardcover: 400 pages
Publisher: Saunders; Har/Psc edition (September 29, 2009)
Language: English
ISBN-10: 1416047115
ISBN-13: 978-1416047117
Product Dimensions: 11 x 8.8 x 0.8 inches
List Price: $145.00

Silva's Diagnostic Renal Pathology

2011-02-23T10:53:00.000-08:00

The kidneys are responsible for many key bodily functions, but their primary role as a filter of toxins makes them extremely susceptible to disease. Often these diseases can only be diagnosed through a renal biopsy, a complicated procedure requiring ancillary immunologic and molecular diagnostic techniques. Many academic centers set aside dedicated laboratories specifically for renal pathology due to the amount of expertise required.

This book covers all methods used by renal pathologists to diagnose a wide range of kidney diseases. Unlike most literature on renal pathology, this book is situated on the midpoint between encyclopedic and superficial coverage, written for the signing-out pathologist. While focusing on tumors and transplantation rejection, a full spectrum of infectious, inflammatory, and congenital disorders is covered in both pediatric and adult populations and is analyzed not only by light microscopy but by each applicable diagnostic modality available. The text is illustrated with more than 1,000 photomicrographs and diagrams, including a CD-ROM of all images.

About the Author

Xin J. Zhou, MD, is professor of pathology and internal medicine at the University of Texas Southwestern Medical Center, Dallas. Dr Zhou is past president of the Chinese American Society of Nephrology and has been practising pathology for more than 22 years.
Zoltan Laszik, MD, is associate professor of clinical pathology at the University of California, San Francisco School of Medicine.
Tibor Nadasdy, MD, is professor of pathology at Ohio State University School of Medicine, Columbus.
Vivette D'Agati, MD, is professor of pathology at New York-Presbyterian Hospital at Columbia University Medical Center, New York.
Fred G. Silva, MD, is secretary-treasurer and CEO of the United States and Canadian Academy of Pathology, Augusta, Georgia. Dr Silva is a preeminent expert in renal pathology and has published hundreds of articles on subjects ranging from diabetic neuropathy to tubulointerstitial disease.

Book Details

Hardcover: 636 pages
Publisher: Cambridge University Press; 1 Har/Cdr edition (April 27, 2009)
Language: English
ISBN-10: 0521877024
ISBN-13: 978-0521877022
Product Dimensions: 11.1 x 8.5 x 1.3 inches

Scheuer's Liver Biopsy Interpretation 8th edition: Expert Consult: Online and Print

2011-02-22T10:57:00.000-08:00

For over 40 years Scheuer's Liver Biopsy Interpretation has been an invaluable resource for the pathologist in practice and in training in helping to solve diagnostic problems at the microscope. Lavishly illustrated in full color throughout it covers all aspects of liver pathology from the normal, the hepatidities, childhood disease and neoplasms. Copious technical tips and diagnostic 'pearls' reflect the extensive experience and insight of the late Peter Scheuer and Jay Lefkowitch.. Throughout the text histopathologic features are correlated with clinical features to provide a practical account of how pathology impacts the diagnosis and management of liver disease.

Book Features

Well written, complete and concise quick reference.Helps the practicing and trainee pathologist solve diagnostic problems at the mircroscope.
High quality color images complement the text throughout.Provides the user with a complete visual guide to each entity and assists in the recognition and diagnosis of any tissue sample under the microscope.
Practical tips and "hands on" advice from two of the world's leading experts in liver pathology. Provides the trainee and general surgical pathologist with time saving diagnostic clues when dealing with difficult specimens.
Glossary of frequently used terms and descriptions used in the pathology report contained at the end of the book. Useful quick reference for trainee pathologists and clinical hepatologists who may be unfamiliar with many of the terms and descriptions. Will assist in the writing and reading of a pathology report.
A selection of a few general reading references at the end of each chapter.Directs the trainee or practitioner to the most relevant and authoritative sources of further information and study.

New in this edition

A brand new chapter: "Practical Principles in Biopsy Assessment". Focus is on interpretation rather than a mere listing of pathological changes. The initial overview of the biopsy specimen provides critical clues to diagnosis and a highly illustrated guide to ddx will be of enormous help in avoiding diagnostic errors.
Expanded coverage throughout, especially of liver tumours, pediatric fatty liver disease, neonatal cholestasis. Keeps the user apprised of the key areas of growth and development in diagnosis and interpretation.
Histopathology correlated with molecular genetics and immunohistochemistry whenever clinically relevant. Keeps the user up-to-date with all of the latest tools for performing a complete and accurate diagnosis.
Many new high-quality colour illustrations. Helps the user identify a wide variety of pathologic lesions.
Text and images available online via Expert Consult.

Book Details

Hardcover: 416 pages
Publisher: Saunders Ltd.; 8 edition (July 28, 2010)
Language: English
ISBN-10: 070203410X
ISBN-13: 978-0702034107
Product Dimensions: 9.9 x 7.7 x 0.9 inches

Hepinstall's Pathology of the Kidney 6th Edition

2011-02-21T10:49:00.000-08:00

This sixth edition of Heptinstall's Pathology of the Kidney has the most dramatic and substantive changes in content of any new edition of this preeminent book on kidney diseases. Yet, still at the core of this edition is the bedrock foundation established by Robert H. Heptinstall, who edited and to a substantial degree authored the first four editions of this classic text. The sixth edition is in essence the 40th anniversary edition of this monumental and comprehensive work, which was first published in 1966.

Since the fifth edition, published in 1998, there have been extraordinary advances in the understanding of the molecular and cellular basis for many kidney diseases, in the knowledge of pathologic and clinical manifestations of kidney diseases, and in the utilization of pathologic findings for directing new and better treatment of kidney diseases. The text of the sixth edition has been extensively modified to include authoritative, thoroughly referenced discussions of these remarkable new advances. Another striking and extremely valuable change in this edition is the transition to color photomicrographs that are even more informative than the traditionally excellent images that have been a hallmark of previous editions.

In his preface to the third edition, Dr. Heptinstall wisely noted that the “two main ingredients for writing a successful medical book are personal experience and an ability to discern what is important in the writing of others.” The 36 authors who contributed to the sixth edition fulfill these criteria admirably. They are among the most capable and accomplished renal pathologists in the world. All of these authors have extensive hands-on experience with diagnostic renal pathology, teaching renal pathology at major medical centers, and advancing the field through clinical and translational research. They have contributed thousands of articles to the literature on renal pathology. In fact, many of the major advances in our current understanding of renal pathology have been made by authors of chapters in this book.

The sixth edition of Heptinstall's Pathology of the Kidney is the most comprehensive, most authoritative, most thoroughly referenced, and best illustrated book on renal pathology ever produced.

Book Details

Hardcover: 1600 pages
Publisher: Lippincott Williams & Wilkins; Sixth edition (October 3, 2006)
Language: English
ISBN-10: 0781747503
ISBN-13: 978-0781747509
Product Dimensions: 11.7 x 9.3 x 4.2 inches

Middleton's Allergy: Principles and Practice 7th Edition: Expert Consult: Online and Print, 2 Volume Set

2011-02-20T10:48:00.000-08:00

Over thirty years ago, Elliott Middleton, Jr., Charles E. Reed, and Elliot F. Ellis conceived of the idea for a new comprehensive textbook of asthma and allergic disorders, and they set about to publish the first edition of Allergy: Principles and Practice. The seventh edition of the now classic Middleton's Allergy: Principles and Practice is an ongoing tribute to the original editors’ foresight in bringing their innovative vision to fruition, subsequent wide acceptance, and preeminence. As stated in their original preface, which is traditionally reprinted in each edition, ‘it is our opinion that some chapters in this book represent the most comprehensive summaries of the subject material found in print. Thus, Allergy: Principles and Practice serves as not only a textbook, but as a reference book.’ Moreover, it was their goal that ‘the final product, turns out to be a book that will be useful to all students of allergy, practitioners, clinical investigators, other researchers, allergy trainees, and medical students.’ Each subsequent edition has also achieved this goal. This book provides updated and new authoritative information on every important aspect of allergic inflammation, and associated allergic disorders.

Fundamental ‘principles’ of allergic inflammation and its origins is addressed in Volume 1 with sections for immunology (including the cellular biology of immunology, as it relates to allergic processes), aerobiology and allergens; and then physiology, which reflects the functional interactions of the sensitized host with its environment. Volume 2 presents the ‘practice’ implications of these basic sciences as they are translated to clinical sciences, the diagnostic approach to the patient, and finally therapeutics. Within this structure, the clinical sciences have attempted to infuse with evidence-based medicine for best practices in the specialty of allergy and clinical immunology.
Book Features

Includes a glossary of allergy and immunology for quick and easy reference.
Contains keypoints and clinical pearls highlighted to find important information quickly.
links to useful online resources both for you and for your patients.
Offers contributions from hundreds of international authorities for world-class expertise in overcoming any clinical challenge.

New in this edition

The growth of knowledge in biomedical science during the past decade has been nothing short of stupendous, and allergy and clinical immunology have been no exceptions to this. To recognize these advances, 14 new chapters have been added to Middleton's seventh edition. These include the new scientific arenas of innate immunity, stem cells, and dendritic cell biology.
A new chapter reviews the factors associated with the increasing prevalence of allergic disorders and asthma.
New clinical chapters detail current knowledge of eosinophilic gastroenteropathies, immunologic non-asthmatic lung diseases, oral challenge testing, approach to the patient with chronic cough, and approach to the patient requiring emergency treatment for acute asthma.
Other new chapters on therapeutics in the seventh edition include the important topics of environmental controls for allergic diseases, adherence to medical regimens, and pharmacogenomics, as well as the evolving role of anti-IgE therapy.
Contains 400 new illustrations, 700 in all, to better illustrate complex immunology.
Covers the very latest in the field, including hot topics such as food allergy and immunotherapy.
Includes the latest guidelines from The National Asthma Education and Prevention Program (NAEPP).
Utilizes a new, more user-friendly full-color format for easier reference.
Includes online access to the entire contents of the book, fully searchable, with links to MEDLINE abstracts for all of the references.

Book Details

Hardcover: 1924 pages
Publisher: Mosby; 7 edition (November 19, 2008)
Language: English
ISBN-10: 0323056598
ISBN-13: 978-0323056595
Product Dimensions: 10.5 x 10.2 x 3.9 inches

Thyroid Cytopathology 2nd Edition by Douglas P. Clark (Springer) 2010

2011-01-29T15:17:00.000-08:00

The evaluation of thyroid nodules by fine needle aspiration (FNA) is one of the most challenging tasks in all of cytopathology. A cytologist must understand the clinical presentation of thyroid diseases, their defining histopathologic and cytopathologic features, and even the intricacies of patient management. Drs. Clark and Faquin have provided a valuable framework for cytologists learning (and continuing to learn) this exacting discipline. Organized around a practical algorithm, the authors lay out a rational and concise approach toward acquiring the necessary skills for the cytologic diagnosis of thyroid nodules. The first edition, published in 2005, was a very welcome addition to the cytology literature. This new edition, with updated terminology for reporting thyroid FNA results, builds on the success of their approach.
Why are we examining such challenging specimens? Clearly, the clinical need is there. Over 50% of adults have one or more thyroid nodules. Surgical excision of all nodules is certainly neither practical nor desirable. Enter FNA, a minimally invasive cellular sampling method that has proven to be a highly useful screening test for thyroid cancer. Because of it, thousands of patients with a benign diagnosis are spared unnecessary surgery every year, and those with cancer are reliably triaged for appropriate therapy.
The large number of FNAs performed in the US is a tribute to its success as a screening test. In many institutions, the thyroid FNA is the most common FNA specimen. For a relatively new diagnostic test, this is a remarkable state of affairs. Thirty years ago, few thyroid cancers were diagnosed by FNA in the US, and in the 1980s some prominent pathologists still questioned the value of FNA for thyroid nodules. There is no more debate: FNA has proven its value. In 2009, an estimated 37,200 thyroid cancers will be diagnosed in the United States, and virtually all of them will have been diagnosed directly or triaged for a diagnostic lobectomy by FNA. If approximately nine FNAs are performed for every thyroid cancer that is discovered, then roughly 335,000 thyroid FNAs will have been performed in the US in 2009.
Cytologists must be armed and ready to evaluate these clinically vital specimens. This book, with its practical algorithm, cogent text, and beautiful illustrations, provides the ammunition a cytologist needs to master thyroid FNA interpretation.

Contents
1 Introduction and Clinical Aspects
2 How to Perform and Process a Thyroid FNA
3 Approach to Thyroid FNA Cytopathology: An Overview
4 Inflammatory Lesions and Lymphoma
5 Colloid-Predominant Lesions
6 Follicular Lesions
7 Hurthle Cell Lesions
8 Cystic Lesions of the Thyroid
9 Papillary Thyroid Carcinoma
10 Medullary Thyroid Carcinoma
11 Undifferentiated (Anaplastic) Carcinoma and Secondary Tumors
Index

Desk Encyclopedia of Human and Medical Virology (Elsevier) 2010

2011-01-27T14:59:00.000-08:00

The Desk Encyclopedia of Human and Medical Virology is the second in a series of four volumes that reproduce many of the chapters in the third edition of the Encyclopedia of Virology, edited by Brian W J Mahy and Marc H V van Regenmortel, published by Academic Press/Elsevier 2008. It contains 81 chapters that relate to human/medical virology. The first section includes 42 chapters that describe general features of common human viruses, and this is followed in Section 2 by five more specialized chapters related to HIV/AIDS. In Section 3, there are 23 chapters describing exotic virus infections, including one now-eradicated virus (smallpox) and some now controlled by vaccination, such as yellow fever. Section 4 includes seven chapters describing some viruses that have been associated with oncogenesis, and Section 5 contains four general chapters of interest to medical virology.
In bringing all these topics under one cover, it is hoped that the book will provide a convenient reference source and an up-to-date introduction to recent advances in medical virology. In combination with the first volume, the Desk Encyclopedia of General Virology, this book could provide excellent material for a teaching course in virology for medical students.

Contents
SECTION I: GENERAL FEATURES OF COMMON HUMAN VIRUSES
Adenoviruses: General Features B Harrach 3
Adenoviruses: Pathogenesis M Benko˝ 11
Anellovirus P Biagini and P de Micco 17
Arboviruses B R Miller 23
Astroviruses L Moser and S Schultz-Cherry 30
Bunyaviruses: General Features R M Elliott 36
Common Cold Viruses S Dreschers and C Adams 45
Coronaviruses: General Features D Cavanagh and P Britton 52
Coxsackieviruses M S Oberste and M A Pallansch 58
Echoviruses T Hyypia¨ 64
Enteric Viruses R F Bishop and C D Kirkwood 69
Flaviviruses: General Features T J Chambers 77
Hepadnaviruses: General Features T J Harrison 88
Hepatitis A Virus A Dotzauer 96
Hepatitis B Virus: General Features P Karayiannis and H C Thomas 103
Hepatitis C Virus R Bartenschlager and S Bu¨ hler 113
Hepatitis Delta Virus J M Taylor 121
Hepatitis E Virus X J Meng 123
Herpesviruses: General Features A J Davison 129
Human Cytomegalovirus: General Features E S Mocarski Jr. and R F Pass 135
Human Herpesviruses 6 and 7 U A Gompels 147
Human Respiratory Syncytial Virus P L Collins 154
Human Respiratory Viruses J E Crowe Jr. 162
Influenza R A Lamb 170
Kaposi’s Sarcoma-Associated Herpesvirus: General Features Y Chang and P S Moore 178
Measles Virus R Cattaneo and M McChesney 184
Molluscum Contagiosum Virus J J Bugert 190
Mumps Virus B K Rima and W P Duprex 195
Noroviruses and Sapoviruses K Y Green 203
Parainfluenza Viruses of Humans E Adderson and A Portner 211
Parvoviruses: General Features P Tattersall 215
Poliomyelitis P D Minor 222
Polyomaviruses M Gravell and E O Major 230
Poxviruses G L Smith, P Beard and M A Skinner 235
Rabies Virus I V Kuzmin and C E Rupprecht 243
Reoviruses: General Features P Clarke and K L Tyler 249
Retroviruses: General Features E Hunter 257
Rhinoviruses N W Bartlett and S L Johnston 266
Rotaviruses J Angel, M A Franco and H B Greenberg 273
Rubella Virus T K Frey 280
Togaviruses: General Features S C Weaver, W B Klimstra and K D Ryman 288
Varicella-Zoster Virus: General Features J I Cohen 298
SECTION II: HUMAN IMMUNODEFICIENCY VIRUSES
AIDS: Disease Manifestation A Rapose, J East, M Sova and W A O’Brien 307
AIDS: Global Epidemiology P J Peters, P H Kilmarx and T D Mastro 314
Human Immunodeficiency Viruses: Antiretroviral Agents A W Neuman and D C Liotta 324
Human Immunodeficiency Viruses: Origin F van Heuverswyn and M Peeters 336
Human Immunodeficiency Viruses: Pathogenesis N R Klatt, A Chahroudi and G Silvestri 345
SECTION III: EXOTIC VIRUS INFECTIONS
Bunyaviruses: Unassigned C H Calisher 357
Cowpox Virus M Bennett, G L Smith and D Baxby 359
Crimean–Congo Hemorrhagic Fever Virus and Other Nairoviruses C A Whitehouse 365
Dengue Viruses D J Gubler 372
Ebolavirus K S Brown, A Silaghi and H Feldmann 382
Filoviruses G Olinger, T W Geisbert and L E Hensley 391
Hantaviruses A Vaheri 398
Henipaviruses B T Eaton and L-F Wang 402
Human T-cell Leukemia Viruses: General Features M Yoshida 408
Japanese Encephalitis Virus A D T Barrett 414
Lassa, Junin, Machupo and Guanarito Viruses J B McCormick 420
Lymphocytic Choriomeningitis Virus: General Features R M Welsh 429
Marburg Virus D Falzarano and H Feldmann 434
Orbiviruses P P C Mertens, H Attoui and P S Mellor 442
Orthobunyaviruses C H Calisher 454
Severe Acute Respiratory Syndrome (SARS) J S M Peiris and L L M Poon 458
Smallpox and Monkeypox Viruses S Parker, D A Schultz, H Meyer and R M Buller 467
St. Louis Encephalitis W K Reisen 472
Tick-Borne Encephalitis Viruses T S Gritsun and E A Gould 479
Togaviruses Causing Rash and Fever D W Smith, J S Mackenzie and M D A Lindsay 488
Transmissible Spongiform Encephalopathies E D Belay and L B Schonberger 497
West Nile Virus L D Kramer 504
Yellow Fever Virus A A Marfin and T P Monath 514
SECTION IV: TUMOR-ASSOCIATED VIRUSES
Adenoviruses: Malignant Transformation and Oncology A S Turnell 525
Epstein–Barr Virus: General Features L S Young 532
Human T-Cell Leukemia Viruses: Human Disease R Mahieux and A Gessain 541
Polyomaviruses of Humans M Safak and K Khalili 551
Retroviral Oncogenes P K Vogt and A G Bader 560
Simian Virus 40 A L McNees and J S Butel 565
Tumor Viruses: Human R Grassmann, B Fleckenstein and H Pfister 574
SECTION V: GENERAL TOPICS
Emerging and Reemerging Virus Diseases of Vertebrates B W J Mahy 583
Herpesviruses: Latency C M Preston 587
Human Eye Infections J Chodosh, A V Chintakuntlawar and C M Robinson 594
Zoonoses J E Osorio and T M Yuill 601
Index 613

Robbins and Cotran Pathologic Basis of Disease 8th Edition (Elsevier) 2010

2011-01-25T14:53:00.000-08:00

One of the best-selling medical textbooks of all time, Robbins and Cotran Pathologic Basis of Disease is the one book that nearly all medical students purchase, and is also widely used by physicians worldwide. A "who's who" of pathology experts delivers the most dependable, current, and complete coverage of today's essential pathology knowledge. At the same time, masterful editing and a practical organization make mastering every concept remarkably easy. The result remains the ideal source for an optimal understanding of pathology.

Preface: The Golden Jubilee Edition
As we launch the 8th edition of Pathologic Basis of Disease we pause to look back 50 years ago, when the first edition of this book, entitled “Pathology with Clinical Correlations” was published. (For those who may not know, the first three editions were published under this name and so the current “8th edition” is really the 11th edition of this book.)
In the preface of the first edition, Stanley Robbins wrote:
   •     “But the study of morphology is only one facet of pathology. Pathology contributes much to clinical medicine. The pathologist is interested not only in the recognition of structural alterations, but also in their significance, i.e., the effects of these changes on cellular and tissue function and ultimately the effect of these changes on the patient. It is not a discipline isolated from the living patient, but rather a basic approach to a better understanding of disease and therefore a foundation of sound clinical medicine.”
   •     “The why's and how's are as important as the what's.”
In today's vocabulary, what Robbins said in 1957 was that pathology is the study of the mechanism of diseases and morphology is a tool (the only one available at that time) to gain insight into pathogenesis and clinical correlations. Over the past 50 years, this focus has not changed and it remains the guiding principle for the current edition. The main difference is that now we have many more tools to supplement morphology, including molecular biology, genetics, and informatics, to name a few. Indeed, it might be said that this book presents the molecular basis of human disease with clinical correlations. This edition, like all previous ones, has been extensively revised, and some areas have been completely rewritten. A few examples of significant changes are as follows:
   •     Chapter 1 has been completely reorganized to include the entire spectrum of cellular responses to injury, from adaptations and sublethal injury to cell death.
   •     Chapter 3 , covering tissue repair and wound healing, has been extensively revised to include new and exciting information on stem cell biology, growth factor signaling, and the mechanisms that underlie fibrosis.
   •     Chapter 5 includes a completely rewritten section on molecular diagnosis that reflects rapid advances in DNA sequencing technology. The principles of genome-wide analysis, now becoming a powerful tool in the study of complex human diseases like cancer and diabetes, have also been added.
   •     Chapter 9 has been completely revised and reorganized in view of the increasing importance of environmental factors in human diseases.
   •     Chapter 17 has been completely rewritten and highlights new insights into the pathogenesis of inflammatory bowel disease and gastrointestinal cancers.
   •     Chapter 22 , covering diseases of the female genital tract, includes discussion of the molecular basis of cancer, endometriosis, and preeclampsia.
   •     In addition to the revision and reorganization of the text, many new photographs and schematics have been added and a large number of the older “gems” have been enhanced by digital technology. Thus, we hope that even the veterans of Robbins Pathology will find the illustrations and figures sparkling and fresh.
Wherever appropriate, we have blended new discoveries into the discussion of pathogenesis and pathophysiology, while never losing sight that the “state of the art” has little value if it does not enhance the understanding of disease mechanisms. As in the past, we have not avoided discussions of “unsolved” problems because of our belief that many who read the text might be encouraged to embark on a path of discovery.
Despite the changes highlighted above, our goals remain the same as those articulated by Robbins and Cotran over the past many years.
   •     To integrate into the discussion of pathologic processes and disorders the newest established information available—morphologic as well as molecular.
   •     To organize information into logical and uniform presentations, facilitating readability, comprehension, and learning.
   •     To maintain the book at a reasonable size and yet provide adequate discussion of the significant lesions, processes, and disorders. Indeed, we have reduced the girth and the weight of this book by trimming out about 80 pages (making it less useful for weight lifting).
   •     To place great emphasis on clarity of writing and proper use of language in the recognition that struggling to comprehend is time-consuming and wearisome and gets in the way of the learning process.
   •     To make this first and foremost a student text—used by students throughout all years of medical school and into their residencies—but, at the same time, to provide sufficient detail and depth to meet the needs of more advanced readers.
We have been repeatedly told by readers that up-todatedness is a special feature that makes this book very valuable. We have strived to remain current by providing new information and references from recent literature, many published in 2008 and some from the early part of 2009. However, older classics have also been retained to provide original source material for advanced readers.
We are now into the digital age and so the text will be available online to those who own the print version. Such access gives the reader the ability to search across the entire text, bookmark passages, add personal notes, and use PubMed to view references, and has many other exciting features. In addition, also available online are case studies, previously available separately as the Interactive Case Study Companion developed by one of us (VK) in collaboration with Herb Hagler, PhD, and Nancy Schneider, MD, PhD, at the University of Texas Southwestern Medical School in Dallas. The cases are designed to enhance and reinforce learning by challenging students to apply their knowledge to solve clinical cases. A virtual microscope feature enables the viewing of selected images at various magnifications.
This edition is also marked by the addition of a new coauthor, Jon Aster. All four of us have reviewed, critiqued, and edited each chapter to ensure the uniformity of style and flow that have been the hallmarks of the book. Together, we hope that we have succeeded in equipping the readers with the scientific basis for the practice of medicine and in whetting their appetite for learning beyond what can be offered in any textbook.

Medical Terminology Simplified - A Programmed Learning Approach by Body System 4th Edition by Barbara A. Gylys (FA Davis) 2010

2011-01-24T15:22:00.000-08:00

The fourth edition of Medical Terminology Simplified: A Programmed Learning Approach by Body System continues to reflect current trends and new approaches to teaching medical terminology. This edition includes a variety of special features to make studying medical terminology a more rewarding experience. The new features have been developed based on feedback from instructors and students. A review of the “What’s Inside” section provides explanations and illustrations about all of the text’s distinctive features. The design and flexibility of Simplified, 4th edition, enables its use as a self-instructional book or in traditional lecture and classroom environments. The organization and pedagogical devices are designed to help instructors teach and students learn medical terminology easily and quickly. When students use the available learning tools, they will find the language of medicine stays with them and they can quickly apply the terminology in the clinical field.
This edition also continues to present eponyms without showing the possessive form, such as Alzheimer disease, Down syndrome, and Parkinson disease. Medical dictionaries as well as the American Association for Medical Transcription and the American Medical Association support these changes. New to this edition is a summary of common symbols as well as an updated list of “do-not-use” abbreviations found in Appendix E, Abbreviations and Symbols. In addition, all outdated medical terms in the textbook have been replaced with the most recent, state-of-the-art terms.

Helping Learners of All Styles
All enhancements and new material in the fourth edition are constructed to improve retention and make the study of medical terminology more enjoyable and engaging. One of the top priorities of this edition, as more and more students identify themselves as visual learners, is to ensure that the illustrations in the text and ancillary products are as helpful to students as possible. Many of the figures depicting the toughest topics for students to grasp have been newly developed; others from the previous edition have been enhanced for more clarity and ease of understanding. Thus, one of the most extraordinary features of this edition is the collection of all-new, visually outstanding, full-color illustrations. They are extremely useful as your students learn the association of medical terms to anatomy, physiology, pathology, and medical treatments of the human body. All of the artwork presents precise depictions of medical terms in action. Full-color figures enable you to see a true representation of the body system, pathological condition, or operative procedure.
It is clear among educators that the most effective method of learning medical terminology is to associate the terms in their appropriate relationship to the human body. This method includes acquiring an understanding of anatomy and physiology, the types of treatments used to cure various disorders, and the disease processes of the human body—all of which are covered in Simplified, 4th edition.

Programmed Learning Approach
The programmed learning approach of this book presents a word-building method for developing a medical vocabulary in an effective and interesting manner. A student can use it in a traditional classroom setting or with guidance from an instructor for independent study. The workbook text format is designed to guide the student through exercises that teach and reinforce medical terminology.
The programmed-learning technique makes use of frames, isolated pieces of information that, together, give the student the building blocks of medical terminology. The frames, each numbered with the chapter number and then the frame number within that chapter, allow students to learn at their own pace and in their own way. Each frame contains not only information about terminology but also fill-in lines students can use to reinforce understanding of the information. The student can find the answer to each fill-in line in the frame’s answer box, located at the left of the page.
The key to using frames wisely is the bookmark included with every book. Students should use it to cover the answer column to verify their understanding of the content provided in the frame. Pronunciation keys for all medical words are also included in the frame answer boxes. Newly designed pronunciation guides in each chapter help students pronounce medical terms correctly.

New Features
To continue developing a contemporary teaching and learning package, we have implemented a number of insightful suggestions from numerous educators and students and updated each body system chapter, including:
■ Newly designed medical specialty section at the beginning of each body system chapter shows students the connection between the body system and its respective medical specialty. This enhancement provides students with an understanding of the responsibilities of health care professionals in various branches of medicine.
■ New summaries of common suffixes and prefixes are presented in Chapter 1. The tables also include an interactive activity to reinforce the student’s knowledge of presented medical terms.
■ Enhanced objectives at the beginning of each chapter continue to help students understand what is essential in the chapter. The reviews and activities are linked directly to these objectives, so both instructors and students can better evaluate competency in each area of study. If the student has not mastered a certain area, they can apply the objectives as a study instrument to help their understanding of the chapter.
■ New pronunciation guides help students pronounce medical terms correctly.
■ Newly designed Additional Medical Terms section helps students understand the connection between common signs, symptoms, and diseases and their diagnoses as well as the rationale behind methods of medical and surgical treatments selected for a particular disorder.
■ New flash-card activities are now available by visiting http://davisplus.fadavis.com/gylys/simplified and downloading each chapter’s Listen-and-Learn exercises. A special icon with instructions directs students to the site so they can preview, practice, and reinforce word elements presented in the chapter.
■ New Symbols section in the Abbreviations appendix lists common symbols used in charting and other areas of health care.
■ Enhanced translations appendix makes it easier for health-care providers who do not speak Spanish to communicate with their Spanish-speaking patients.
The popular and effective features found in the previous edition have been expanded and enhanced. Here’s a breakdown of those features:
■ Chapter 1 introduces the programmed learning and the medical word-building approach. It also
includes a summary of common suffixes and prefixes used in medical word building.
■ Chapter 2 discusses the structural organization of the human body.
■ Chapters 3 to 11 are organized according to specific body systems and may be taught in any sequence.
These chapters include key anatomical and physiological terms; anatomy and physiology; combining forms, suffixes, and prefixes; terms related to signs, symptoms, and diseases as well as diagnostic, surgical and medical procedures; and abbreviations. Included are section reviews and medical record activities. All activities allow self-assessment and evaluation of competency.

Appendices
The textbook’s appendices also offer learning tools to help reinforce the information presented in the chapters. Your students will also find the appendices useful for study, review, and reference as they begin their careers in the allied heath field:
■ Appendix A: Glossary of Medical Word Elements contains alphabetical lists of medical word elements with corresponding meanings.
■ Appendix B: Answer Key provides answers to anatomical labeling and section and chapter reviews as well as the medical records activities.
■ Appendix C: Index of Diagnostic, Medical, and Surgical Procedures summarizes procedures covered in the textbook that establish a diagnosis as well as various methods of treatment.
■ Appendix D: Drug Classifications provides information on prescription and nonprescription drugs used for the treatment of various medical conditions.

Ganong’s Review of Medical Physiology 23rd Edition

2011-01-23T14:48:00.000-08:00

The current authors have attempted to maintain the highest standards of excellence, accuracy, and pedagogy developed by Fran Ganong over the 46 years in which he educated countless students worldwide with this textbook. At the same time, the authors have been attuned to the evolving needs of both students and professors in medical physiology. Thus, in addition to usual updates on the latest research and developments in areas such as the cellular basis of physiology and neurophysiology, this edition has added both outstanding pedagogy and learning aids for students. This edition is a revision of the original works of Dr. Francis Ganong.
Thoroughly updated to reflect the latest research and developments in important areas such as the cellular basis of neurophysiology, Ganong's Review of Medical Physiology incorporates examples from clinical medicine throughout the chapters to illustrate important physiologic concepts. Whether you're a student who needs an outstanding review for the USMLE or a physician who wants to keep pace with the ever-changing field of medical physiology, there's no better place to turn than Ganong's Review of Medical Physiology.

New in this edition
New 4 Color Illustrations
This edition provide an accurate, up-to-date, and visually appealing new illustration program. Full-color illustrations and tables are provided throughout, which also include detailed figure legends that tell a short story or describes the key point of the illustration.

New 8 1/2 x 11 Format
Based on student and instructor focus groups, we have increased the trim size, which will provide additional white space and allow our new art program to really show!
New Boxed Clinical Cases
Examples of diseases illustrating important physiological principles are provided in boxed Clinical Cases.
New End of Chapter Board Review Questions
New to this edition, chapters now conclude with board review questions.
New Media

This new edition has focused on creating new student content that is built upon learning outcomes and assessing student performance. Free with every student copy is an iPod Review Tutorial Product. Questions and art based from each chapter tests students comprehension and is easy to navigate with a simple click of the scroll bar!
Online Learning Center will provide students and faculty with cases and art and board review questions on a dedicated website.

About the Author

Kim E. Barrett received her PhD in biological chemistry from University College London in 1982. Following postdoctoral training at the National Institutes of Health, she joined the faculty at the University of California, San Diego, School of Medicine in 1985, rising to her current rank of Professor of Medicine in 1996. Since 2006, she has also served the University as Dean of Graduate Studies. Her research interests focus on the physiology and pathophysiology of the intestinal epithelium, and how its function is altered by commensal, probiotics, and pathogenic bacteria as well as in specific disease states, such as inflammatory bowel diseases. She has published almost 200 articles, chapters, and reviews, and has received several honors for her research accomplishments including the Bowditch and Davenport Lectureships from the American Physiological Society and the degree of Doctor of Medical Sciences, honoris causa, from Queens University, Belfast. She is also a dedicated and award-winning instructor of medical, pharmacy, and graduate students, and has taught various topics in medical and systems physiology to these groups for more than 20 years. Her teaching experiences led her to author a prior volume (Gastrointestinal Physiology, McGraw-Hill, 2005) and she is honored to have been invited to take over the helm of Ganong.
Susan M. Barman received her PhD in physiology from Loyola University School of Medicine in Maywood, Illinois. Afterward she went to Michigan State University (MSU) where she is currently a Professor in the Department of Pharmacology/ Toxicology and the Neuroscience Program. Dr Barman has had a career-long interest in neural control of cardiorespiratory function with an emphasis on the characterization and origin of the naturally occurring discharges of sympathetic and phrenic nerves. She was a recipient of a prestigious National Institutes of Health MERIT (Method to Extend Research in Time) Award. She is also a recipient of an Outstanding University Woman Faculty Award from the MSU Faculty Professional Women's Association and an MSU College of Human Medicine Distinguished Faculty Award. She has been very active in the American Physiological Society (APS) and recently served on its council. She has also served as Chair of the Central Nervous System Section of APS as well as Chair of both the Women in Physiology and Section Advisory Committees of APS. In her spare time, she enjoys daily walks, aerobic exercising, and mind-challenging activities like puzzles of various sorts.
Scott Boitano received his PhD in genetics and cell biology from Washington State University in Pullman, Washington, where he acquired an interest in cellular signaling. He fostered this interest at University of California, Los Angeles, where he focused his research on second messengers and cellular physiology of the lung epithelium. He continued to foster these research interests at the University of Wyoming and at his current positions with the Department of Physiology and the Arizona Respiratory Center, both at the University of Arizona.
Heddwen L. Brooks received her PhD from Imperial College, University of London and is an Associate Professor in the Department of Physiology at the University of Arizona (UA). Dr Brooks is a renal physiologist and is best known for her development of microarray technology to address in vivo signaling pathways involved in the hormonal regulation of renal function. Dr Brooks’ many awards include the American Physiological Society (APS) Lazaro J. Mandel Young Investigator Award, which is for an individual demonstrating outstanding promise in epithelial or renal physiology. She will receive the APS Renal Young Investigator Award at the 2009 annual meeting of the Federation of American Societies for Experimental Biology. Dr Brooks is a member of the APS Renal Steering Section and the APS Committee of Committees. She is on the Editorial Board of the American Journal of Physiology-Renal Physiology (since 2001), and she has also served on study sections of the National Institutes of Health and the American Heart Association.

Contents
SECTION I CELLULAR & MOLECULAR BASIS FOR MEDICAL PHYSIOLOGY 1
1. General Principles & Energy Production in Medical Physiology 1
2. Overview of Cellular Physiology in Medical Physiology 31
3. Immunity, Infection, & Inflammation 63
SECTION II PHYSIOLOGY OF NERVE & MUSCLE CELLS 79
4. Excitable Tissue: Nerve 79
5. Excitable Tissue: Muscle 93
6. Synaptic & Junctional Transmission 115
7. Neurotransmitters & Neuromodulators 129
8. Properties of Sensory Receptors 149
9. Reflexes 157
SECTION III CENTRAL & PERIPHERAL NEUROPHYSIOLOGY 167
10. Pain & Temperature 167
11. Somatosensory Pathways 173
12. Vision 181
13. Hearing & Equilibrium 203
14. Smell & Taste 219
15. Electrical Activity of the Brain, Sleep–Wake States, & Circadian Rhythms 229
16. Control of Posture & Movement 241
17. The Autonomic Nervous System 261
18. Hypothalamic Regulation of Hormonal Functions 273
19. Learning, Memory, Language, & Speech 289
SECTION IV ENDOCRINE & REPRODUCTIVE PHYSIOLOGY 301
20. The Thyroid Gland 301
21. Endocrine Functions of the Pancreas & Regulation of Carbohydrate Metabolism 315
22. The Adrenal Medulla & Adrenal Cortex 337
23. Hormonal Control of Calcium and Phosphate Metabolism & the Physiology of Bone 363
24. The Pituitary Gland 377
25. The Gonads: Development & Function
of the Reproductive System 391
SECTION V GASTROINTESTINAL PHYSIOLOGY 429
26. Overview of Gastrointestinal Function & Regulation 429
27. Digestion, Absorption, & Nutritional Principles 451
28. Gastrointestinal Motility 469
29. Transport & Metabolic Functions of the Liver 479
SECTION VI CARDIOVASCULAR PHYSIOLOGY 489
30. Origin of the Heartbeat & the Electrical Activity of the Heart 489
31. The Heart as a Pump 507
32. Blood as a Circulatory Fluid & the Dynamics of Blood & Lymph Flow 521
33. Cardiovascular Regulatory Mechanisms 555
34. Circulation Through Special Regions 569
SECTION VII RESPIRATORY PHYSIOLOGY 587
35. Pulmonary Function 587
36. Gas Transport & pH in the Lung 609
37. Regulation of Respiration 625
SECTION VIII RENAL PHYSIOLOGY 639
38. Renal Function & Micturition 639
39. Regulation of Extracellular Fluid Composition & Volume 665
40. Acidification of the Urine & Bicarbonate Excretion 679
Answers to Multiple Choice Questions 687
Index 689

Product Details

Paperback: 726 pages
Publisher: McGraw-Hill Medical; 23 edition (July 24, 2009)
Language: English
ISBN-10: 0071605673
ISBN-13: 978-0071605670
Product Dimensions: 10.7 x 8.5 x 1.1 inches
Author: Kim E. Barrett, Susan M. Barman, Scott Boitano and Heddwen Brooks

List Price: $64.95

Agur: Grant's Atlas of Anatomy 12th Edition

2011-01-22T14:42:00.000-08:00

This edition of Grant's Atlas has, like its predecessors, required intense research, market input, and creativity. It is not enough to rely on a solid reputation; with each new edition, they have adapted and changed many aspects of the Atlas while maintaining the commitment to pedagogical excellence and anatomical realism that has enriched its long history. Medical and health sciences education, and the role of anatomy instruction and application within it, continually evolve to reflect new teaching approaches and educational models. The health care system itself is changing, and the skills and knowledge that future health care practitioners must master are changing along with it. Finally, technologic advances in publishing, particularly in online resources and electronic media, have transformed the way students access content and the methods by which educators teach content. All of these developments have shaped the vision and directed the execution of this twelfth edition of Grant's Atlas, as evidenced by the following key features:

Classic Grant's images updated for today's students. A unique feature of Grant's Atlas is that, rather than providing an idealized view of human anatomy, the classic illustrations represent actual dissections that the student can directly compare with specimens in the lab. Because the original models used for these illustrations were real cadavers, the accuracy of these illustrations is unparalleled, offering students the best introduction to anatomy possible. Over the years they have made many changes to the illustrations to match the shifting expectations of students, adding more vibrant colors and updating the style from the original carbon-dust renderings. In this edition, at the suggestion of reviewers, the author have continued this trend by introducing more lifelike skin tones to provide a more realistic but no less accurate depiction of anatomy. In addition, almost all of these dissection figures were carefully analyzed to ensure that label placement remained effective and that the illustration's relevance was still clear. Almost every figure in this edition of Grant's Atlas was altered, from simple label changes to full-scale revision.

Schematic illustrations to facilitate learning. Full-color schematic illustrations supplement the dissection figures to clarify anatomical concepts, show the relationships of structures, and give an overview of the body region being studied. Many new schematic illustrations have been added to this edition; others have been revised to refine their pedagogical aspects. All conform to Dr. Grant's admonition to keep it simple: extraneous labels were deleted, and some labels were added to identify key structures and make the illustrations as useful as possible to students. In addition, many new, simple orientation drawings were added for ease of identifying dissected regions.

Legends with easy-to find clinical applications. Admittedly, artwork is the focus of any atlas; however, the Grant's legends have long been considered a unique and valuable feature of the Atlas. The observations and comments that accompany the illustrations draw attention to salient points and significant structures that might otherwise escape notice. Their purpose is to interpret the illustrations without providing exhaustive description. Readability, clarity, and practicality were emphasized in the editing of this edition. For the first time, clinical comments, which deliver practical pearls that link anatomic features with their significance in health care practice, are highlighted in blue within the figure legends. The clinical comments have also been expanded in this edition, providing even more relevance for students searching for medical application of anatomical concepts.

Enhanced diagnostic and surface anatomy and images. Because medical imaging have taken on increased importance in the diagnosis and treatment of injuries and illnesses, diagnostic images are used liberally throughout the chapters, and a special imaging section appears at the end of each chapter. Over 100 clinically relevant magnetic resonance images (MRIs), computed tomography (CT) scans, ultrasound scans, and corresponding orientation drawings are included in this edition. They have also increased the number of labeled surface anatomy photographs and introduced greater ethnic diversity in the surface anatomy representations.

Tables updated, expanded, and improved. Another feature unique to Grant's Atlas is the use of tables to help students organize complex information in an easy-to-use format ideal for review and study. The eleventh edition saw the introduction of muscle tables. In this edition, expanded the tables to include those for nerves, arteries, veins, and other relevant structures. The table format in this edition also received a substantial update; a consistent color code is used to clearly demarcate columns. Many tables are also strategically placed on the same page as the illustrations that demonstrate the structures listed in the tables.

Logical organization and layout. The organization and layout of the Atlas has always been determined with ease-of-use as the goal. Although the basic organization by body region was maintained in this edition, the order of plates within every chapter was scrutinized to ensure that it is logical and pedagogically effective. Sections within each chapter further organize the region into discrete subregions; these subregions appear as titles on the pages. Readers need only glance at these titles to orient themselves to the region and subregion that the figures on the page belong to. All sections also appear as a table of contents on the first page of each chapter.

Helpful learning and teaching tools. For the first time in its history, the twelfth edition of Grant's Atlas offers a wide range of electronic ancillaries for both student and teacher on Lippincott Williams & Wilkins' online ancillary site thePoint (http://thepoint.lww.com/grantsatlas). Students are given access to an interactive electronic atlas containing all of the atlas images with full search capabilities as well as zoom and compare features, as well as selected video clips from the best-selling Acland's DVD Atlas of Human Anatomy collection. Students can test themselves with 300 multiple choice questions, 95 drag-and-drop labeling exercises, and a sampling of Clinical Anatomy Flash Cards. For instructors, electronic ancillaries include an interactive atlas with slideshow and image-export functions, an image bank, and se-lected dissection sequences of plates.

You will enjoy using this twelfth edition of Grant's Atlas and that it becomes a trusted partner in your educational experience. This new edition safeguards the Atlas's historical strengths while enhancing its usefulness to today's students.

Product Details

Paperback: 834 pages
Publisher: Lippincott Williams & Wilkins; Twelfth, North American Edition edition (February 15, 2008)
Language: English
ISBN-10: 0781770556
ISBN-13: 978-0781770552
Product Dimensions: 10.9 x 9.2 x 1.5 inches

List Price: $82.50

Mohs Surgery and Histopathology Beyond the Fundamentals (Cambridge University Press) 2009

2011-01-21T14:37:00.000-08:00

Mohs Surgery and Histopathology Beyond the Fundamentals is a highly effective technique for the surgical removal of most types of cutaneous and oral pharyngeal cancers. The procedure allows for the precise and complete removal of cancers while maximizing the preservation of surrounding normal tissue. Through the presentation and orientation of the specimens’ complete surgical margin on pathology slides, the location of tumor foci and other relevant findings can be correlated with their locations on the surgical wound. The ability to create perfect slides for histological examination lies at the core of effective Mohs surgery. This procedure has the highest cure rate among alternative cancer treatment modalities for the cancers for which it is utilized.
This book describes the methods the Mohs surgeon-pathologist and Mohs technician use to optimize the Mohs technique and produce the highest-quality slides and highest cure rates possible, and it breaks new ground in describing techniques that the Mohs technician uses in the lab.

About the Author

Ken Gross, MD, is non-salaried Clinical Professor in the Division of Dermatology at the University of California, San Diego School of Medicine, San Diego, and is also in private practice limited to the treatment of skin cancer in San Diego, California.
Howard K. Steinman, MD, is Director of Dermatologic and Skin Cancer Surgery and Associate Professor of Dermatology at the Texas A&M University Health Sciences Center College of Medicine, Scott and White Medical Center, Temple, Texas.

Contents
Part I Microscopy and tissue preparation
Chap. 1. Introduction
Chap. 2. How to excise tissue for optimal sectioning
Chap. 3. Optimizing the mohs microscope
Chap. 4. Tissue preparation and chromacoding
Chap. 5. Embedding techniques
Part II Introduction to laboratory techniques
Chap. 6. Lab pearls: making great slides preparing slides with cartilage
Chap. 7. Lab pearls: staining, inking, and coverslipping
Chap. 8. Lab pearls: troubleshooting slide quality
Chap. 9. Mohs slides organization and standardization for effective interpretation
Chap. 10. Mohs mapping
Part III Microanatomy and neoplastic disease
Chap. 11. Normal microanatomy: vertical and horizontal
Chap. 12. Basal cell carcinoma: vertical and horizontal
Chap. 13. Squamous cell carcinoma: vertical and horizontal
Chap. 14. Unusual tumors: vertical and horizontal
Chap. 15. Mohs for melanoma
Chap. 16. Taking stages beyond stage i
Chap. 17. Perineural tumors
Part IV Special techniques and stains
Chap. 18. Fixed-tissue mohs
Chap. 19. Toluidine blue stain for mohs micrographic surgery
Chap. 20. Forms and templates for mohs surgery
Index

Vander’s Renal Physiology 7th Edition (McGraw-Hill) 2009

2011-01-20T14:37:00.000-08:00

In the several years since publication of the previous edition of Vander’s Renal Physiology, the creative work of the research community has penetrated ever more deeply into the intricacies of signaling systems that regulate events in different regions of the kidney. This progress not only gives a more complete picture of how the kidney accomplishes its various tasks, but also presents a still bigger challenge to the student to learn the principles of renal function in an integrated manner that is not split into isolated fragments. The approach in this text is to distill the essence of renal processes and their regulation into a core that is accurate, yet not so burdened with detail that it overwhelms the reader. Rather than add complexity, the authors have purposely limited detail in order to keep the reader focused on the logic of renal processes. Accordingly, the goals in the preparation of this edition were :

(1) to incorporate the results of new literature,
(2) point out the logical connection between events at the cellular level and their consequences for the well being of the body, and
(3) to revise the text to improve its clarity.

Consistent with prior editions allot considerable coverage to body systems other than the kidneys, particularly the cardiovascular system, in order to bring out how the kidneys influence those systems, and in turn are influenced by those systems.
To help orient the reader and to prevent students from being mired in details, this text have added key concepts at the end of each chapter. This feature also highlights the major points throughout the text and allows easy and quick review. These key concepts, together with the learning objectives, will be effective tools in learning renal physiology.

Contents
Chapter 1 Renal Functions, Anatomy, and Basic Processes 1
Functions / 2
Anatomy of the Kidneys and Urinary System / 4
The Nephron / 5
Blood Supply to the Nephrons / 12
Basic Renal Processes / 16
Chapter 2 Renal Blood Flow and Glomerular Filtration 24
Glomerular Filtration and Renal Blood Flow / 25
Flow, Resistance, and Pressure in the Kidneys / 25
Glomerular Filtration / 26
Autoregulation / 34
Chapter 3 Clearance 38
Clearance Units / 39
Plasma Creatinine and Urea Concentrations as Indicators of GFR Changes / 43
Chapter 4 Basic Transport Mechanisms 47
Crossing the Epithelial Barriers / 47
Receptor-Mediated Endocytosis and Transcytosis / 53
Transport Mechanisms in Reabsorption / 55
Chapter 5 Renal Handling of Organic Substances 63
Active Proximal Reabsorption of Organic Nutrients (eg, Glucose, Amino Acids) / 64
Proteins and Peptides / 66
Active Proximal Secretion of Organic Anions / 68
Active Proximal Secretion of Organic Cations / 70
pH Dependence of Passive Reabsorption or Secretion / 74
Urea / 74
Chapter 6 Basic Renal Processes for Sodium, Chloride, and Water 77
Overview / 78
Individual Tubular Segments / 84
Urinary Concentration: The Medullary Osmotic Gradient / 93
Chapter 7 Control of Sodium and Water Excretion: Regulation of Plasma Volume and Plasma Osmolality and Renal Control of Systemic Blood Pressure 102
Regulation of Blood Pressure / 104
Contribution of the Kidney to the Regulation of Sodium Excretion and Blood Pressure / 110
Control of Water Excretion / 131
Chapter 8 Renal Regulation of Potassium Balance 140
Regulation of Potassium Between the Intracellular and Extracellular Compartments / 141
Renal Potassium Handling / 143
Chapter 9 Regulation of Hydrogen Ion Balance 155
Guidelines for Studying Acid-Base Biology / 156
Renal Handling of Acids and Bases / 162
Renal Excretion of Acid and Base / 165
Hydrogen Ion Excretion on Urinary Buffers / 167
Phosphate and Organic Acids as Buffers / 169
Hydrogen Ion Excretion on Ammonium / 170
Quantification of Renal Acid-Base Excretion / 174
Regulation of the Renal Handling of Acids and Bases / 176
Control of Renal Glutamine Metabolism and NH4+ Excretion / 177
Intravenous Solutions: Lactated Ringer’s / 178
Specific Categories of Acid-Base Disorders / 179
Renal Response to Metabolic Acidosis and Alkalosis / 180
Factors Causing the Kidneys to Generate or Maintain A Metabolic Alkalosis / 181
Chapter 10 Regulation of Calcium and Phosphate Balance 185
Effector Sites for Calcium Balance / 188
Hormonal Control of Effector Sites / 192
PTH / 193
Overview of Renal Phosphate Handling / 197
Answers to Study Questions 201
Appendix A 209
Appendix B 211
Index 213

Porth's Essentials of Pathophysiology: Concepts of Altered Health States 3rd edition

2010-12-15T00:09:00.000-08:00

Porth's Essentials of Pathophysiology, Third Edition delivers exceptional student understanding and comprehension of pathophysiology. An expanded, robust and flexible suite of supplements makes it easy for you to select the best course resources, so you can meet your students' changing needs. For both discrete and hybrid courses, the flexibility and power of Porth allows you to customize the amount of pathophysiology that you need for effective teaching and learning.

Product Details

Paperback: 1280 pages
Publisher: Lippincott Williams & Wilkins; Third, North American Edition (October 15, 2010)
Language: English
ISBN-10: 1582557241
ISBN-13: 978-1582557243
Product Dimensions: 10.8 x 8.3 x 1.8 inches